Cutaneous wound healing

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

“…FAP has been reported to cleave type I collagen [ 11 – 14 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This activity was confirmed using recombinant FAP and fluorescently quenched (DQ) collagen substrates that fluoresce when cleaved.…”

“…Macrophages infiltrate and are retained in the tumor microenvironment through expression of specific adhesion proteins, such as integrins and scavenger receptors, that bind and mediate the adhesion of cells to ECM components of the tumor stroma. Interestingly, macrophages do not adhere well to native type I collagen [ 19 , 20 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This suggests that modifications of collagen are necessary for macrophage adhesion.…”

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

“…FAP has been reported to cleave type I collagen [ 11 – 14 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This activity was confirmed using recombinant FAP and fluorescently quenched (DQ) collagen substrates that fluoresce when cleaved.…”

“…Macrophages infiltrate and are retained in the tumor microenvironment through expression of specific adhesion proteins, such as integrins and scavenger receptors, that bind and mediate the adhesion of cells to ECM components of the tumor stroma. Interestingly, macrophages do not adhere well to native type I collagen [ 19 , 20 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This suggests that modifications of collagen are necessary for macrophage adhesion.…”

The Nuts and Bolts of Low-level Laser (Light) Therapy

“…to treat skin ulcers. 69-71 LLLT is believed to affect all three phases of wound healing 111 : the inflammatory phase, in which immune cells migrate to the wound, the proliferative phase, which results in increased production of fibroblasts and macrophages, and the remodeling phase, in which collagen deposition occurs at the wound site and the extra-cellular matrix is rebuilt.…”

Glu-Leu-Arg-Negative CXC Chemokine Interferon γ Inducible Protein-9 As a Mediator of Epidermal–Dermal Communication During Wound Repair

“…Key words: cell motility/CXC chemokines/ epidermal growth factor receptor/calpain/wound healing. J Invest Dermatol 120:1110 ^1117, 2003 W ound healing is a complex process of tissue deposition and remodeling resulting in the regeneration of an intact skin barrier and functional organ (Gailit and Clark, 1994;Thomas et al, 1995). The complexity of this process is accentuated by the fact that skin is comprised of two distinct compartments, the ectodermally derived epithelial epidermis and the mesodermally derived mesenchymal dermis, which are separated by a basement membrane barrier.…”

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

“…FAP has been reported to cleave type I collagen [ 11 – 14 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This activity was confirmed using recombinant FAP and fluorescently quenched (DQ) collagen substrates that fluoresce when cleaved.…”

“…Macrophages infiltrate and are retained in the tumor microenvironment through expression of specific adhesion proteins, such as integrins and scavenger receptors, that bind and mediate the adhesion of cells to ECM components of the tumor stroma. Interestingly, macrophages do not adhere well to native type I collagen [ 19 , 20 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This suggests that modifications of collagen are necessary for macrophage adhesion.…”

The Nuts and Bolts of Low-level Laser (Light) Therapy

“…to treat skin ulcers. 69-71 LLLT is believed to affect all three phases of wound healing 111 : the inflammatory phase, in which immune cells migrate to the wound, the proliferative phase, which results in increased production of fibroblasts and macrophages, and the remodeling phase, in which collagen deposition occurs at the wound site and the extra-cellular matrix is rebuilt.…”

Glu-Leu-Arg-Negative CXC Chemokine Interferon γ Inducible Protein-9 As a Mediator of Epidermal–Dermal Communication During Wound Repair

“…Key words: cell motility/CXC chemokines/ epidermal growth factor receptor/calpain/wound healing. J Invest Dermatol 120:1110 ^1117, 2003 W ound healing is a complex process of tissue deposition and remodeling resulting in the regeneration of an intact skin barrier and functional organ (Gailit and Clark, 1994;Thomas et al, 1995). The complexity of this process is accentuated by the fact that skin is comprised of two distinct compartments, the ectodermally derived epithelial epidermis and the mesodermally derived mesenchymal dermis, which are separated by a basement membrane barrier.…”

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

“…FAP has been reported to cleave type I collagen [ 11 – 14 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This activity was confirmed using recombinant FAP and fluorescently quenched (DQ) collagen substrates that fluoresce when cleaved.…”

“…Macrophages infiltrate and are retained in the tumor microenvironment through expression of specific adhesion proteins, such as integrins and scavenger receptors, that bind and mediate the adhesion of cells to ECM components of the tumor stroma. Interestingly, macrophages do not adhere well to native type I collagen [ 19 , 20 ], which is the most abundant ECM protein in a tumor stroma [ 21 ]. This suggests that modifications of collagen are necessary for macrophage adhesion.…”

The Nuts and Bolts of Low-level Laser (Light) Therapy

“…to treat skin ulcers. 69-71 LLLT is believed to affect all three phases of wound healing 111 : the inflammatory phase, in which immune cells migrate to the wound, the proliferative phase, which results in increased production of fibroblasts and macrophages, and the remodeling phase, in which collagen deposition occurs at the wound site and the extra-cellular matrix is rebuilt.…”

Glu-Leu-Arg-Negative CXC Chemokine Interferon γ Inducible Protein-9 As a Mediator of Epidermal–Dermal Communication During Wound Repair

“…Key words: cell motility/CXC chemokines/ epidermal growth factor receptor/calpain/wound healing. J Invest Dermatol 120:1110 ^1117, 2003 W ound healing is a complex process of tissue deposition and remodeling resulting in the regeneration of an intact skin barrier and functional organ (Gailit and Clark, 1994;Thomas et al, 1995). The complexity of this process is accentuated by the fact that skin is comprised of two distinct compartments, the ectodermally derived epithelial epidermis and the mesodermally derived mesenchymal dermis, which are separated by a basement membrane barrier.…”