Cutaneous vasculitis and rheumatoid factor positivity as presenting signs of hepatitis C virus-induced mixed cryoglobulinemia

Karlsberg, P. L.

doi:10.1001/archderm.131.10.1119

Cited by 24 publications

(13 citation statements)

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“…Positivity for RF seems to reflect the development of cutaneous vasculitis in patients with HCV-related MC. Karisberg and his colleagues demonstrated that all HCV-related MC patients with cutaneous vasculitis had RF and liver involvement [67]. The detection of Type II cryoglobulins containing RF (type II-RF) appeared to monitor cryoglobulinemic vasculitis in those patients [68].…”

Section: Extrahepatic Manifestations and Their Associated Autoantimentioning

confidence: 99%

Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

Himoto

Masaki

2012

Clinical and Developmental Immunology

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Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren's syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders.

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Section: Extrahepatic Manifestations and Their Associated Autoantimentioning

confidence: 99%

Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

Himoto

Masaki

2012

Clinical and Developmental Immunology

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“…The purpose of this report is to ensure practitioners remain aware of the possibility of HCV infection in patients presenting with palpable purpura, livedo reticularis or urticaria. 12 This is especially pertinent considering studies have shown up to 8% of patients with a mixed cryoglobulinaemia and leukocytoclastic vasculitis have anti-HCV antibodies. 13 …”

Section: Discussionmentioning

confidence: 99%

An interesting rash: leucocytoclastic vasculitis with type 2 cryoglobulinaemia

Mannu

2010

JRSM Short Reports

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“…Also, in retrospect our patient did not have any family history of psoriasis, or psoriasis. Skin manifestations of PAN may include: tender erythematous nodules, purpura, livedo reticularis, ulcers, and bullous or vesicular eruption ( 12 – 14 ). These are different from our patient’s rash.…”

Section: Our Casementioning

confidence: 99%

A case of acute generalized exanthematous pustulosis associated with polyarteritis nodosa, responding to systemic steroids

Alkhachroum

Kazzaz

2015

Journal of Community Hospital Internal Medicine Perspectives

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A patient with a known biopsy of polyarteritis nodosa diagnosis presented with cyclic fevers, acute kidney injury, and progression of rash from macular to pustular, worsening despite being on antibiotics, without evidence of infection on multiple cultures. The patient had a pathological diagnosis from a skin biopsy of acute generalized exanthematous pustulosis syndrome, with a total resolution of rash, fevers, and acute kidney injury on treatment with pulse steroids.

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Cutaneous vasculitis and rheumatoid factor positivity as presenting signs of hepatitis C virus-induced mixed cryoglobulinemia

Cited by 24 publications

References 0 publications

Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

An interesting rash: leucocytoclastic vasculitis with type 2 cryoglobulinaemia

A case of acute generalized exanthematous pustulosis associated with polyarteritis nodosa, responding to systemic steroids

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