Cutaneous toxicity of bleomycin therapy

Dose and Regimen Effects of Poly ICLC, an Interferon Inducer, in a Multi‐Dose Bleomycin Model of Interstitial Pulmonary Fibrosis*

“…The weight results indicate that semiweekly administration of poly ICLC plus bleomycin treatment may produce substantial toxicity, but not in a dose-dependent manner. The synergistic toxicity produced by concomitant administration of bleomycin and poly ICLC in this study is supported by experimental evidence indicating that both bleomycin (Ichikawa et al 1967;Cohen et al 1973) and poly ICLC (Hartmann et al 1987) administered alone may produce organ specific and systemic toxicity. If both bleomycin and poly ICLC did produce toxicity, in some cases affecting the same organ systems, then significant toxicity of a synergistic nature might be the expected result.…”

Bleomycin-Induced Raynaud’s Phenomenon and Acral Sclerosis

“…A thickening of the wall of some blood vessels was ob served. Moreover, there was an increase of the dermal collagen with focal areas of ho mogenization, which were mainly around blood vessels and adnexa [2], Both in vivo and in vitro. BLM is capable of stimulating the synthesis of collagen and glucosaminoglycans.…”

Combined local and systemic bleomycin administration in electrochemotherapy to reduce the number of treatment sessions

“…Reducing anesthesia procedures outweighs the risk of adverse reactions related to the accumulated dose of bleomycin. 23 , 24 …”