Objective: Skin tag (fibroepithelial polyp) is a benign skin lesion that is composed of a core of connective tissue and overlying epidermis with unknown etiology and pathogenesis. We conducted this study to demonstrate its relationship with elastic fiber abnormality.
Methods:We retrieved thirty histopathological cases of fibroepithelial polyps at king khalid University hospital, Riyadh, Saudi Arabia, during the period from 2010 to 2012. The cases were stained with elastic van Gieson stain.Results: All the cases showed thinned dermal elastic fibers and twenty one revealed decrease in their count.
Conclusion: Fibroepithelial polyps show abnormal and/or decreased elastic fibers.There were 12 females and 18 males. The lesions were located most commonly on neck (n: 11) and thigh (n: 7) (Table 1). By Hematoxylin and eosin (H/E) stain, the lesion composed of a core of connective tissue covered by papillated epidermal surface (Figure 1). There were 17 furrowed, 7 bag-like and 6 filiform types. Elasticvan Gieson stain showed moderate to marked thinning of elastic fibers (EF) in all the cases as compared to normal control skin. Twenty one cases revealed reduced number of EF (Figure 2(A & B)).