Cutaneous T-lymphocyte lymphoma in association with multiple myeloma

Abstract

We report a case of cutaneous T-lymphocyte lymphoma in which multiple myeloma, a B-lymphocyte neoplasm, developed. We also review the emerging evidence on the immunoregulatory capacity of neoplastic T lymphocytes. Our case clinically supports the notion that neoplastic T lymphocytes may sometimes express helper activity for a specific B-lymphocyte clone (idiotype-specific helper function).

Coexistent B-cell Lymphoma and Cutaneous T-cell Lymphoma

“…(9,16,17). However, that was also considered unlikely in our patient, since malignancies and lymphoproliferative disorders were not apparent in his immediate family or related members.…”

A case of Sezary's syndrome associated with granulomatous lesions, myelodysplastic syndrome and transformation into CD30-positive large-cell pleomorphic lymphoma

“…8 T-cell receptor (TCR) genes are clonally rearranged in the peripheral blood, skin and lymph nodes. 9,10 Unusual and rare features of SS include its association with monoclonal gammopathies or myeloma [11][12][13][14] or other B-cell proliferations, 15 development of granulomatous lesions, [16][17][18] association with myelodysplastic syndrome (MDS), [19][20][21] transformation into a high-grade malignant lymphoma, [22][23][24][25] and development of various secondary neoplasms. 26 We report a patient with SS, who developed several unusual features during the course of the disease, namely granulomatous lesions harbouring dominant T-cell clone, transformation into CD30-positive largecell pleomorphic T-cell lymphoma, and MDS.…”

Angioimmunoblastic T-Cell Lymphoma with Coexisting Plasma Cell Myeloma: A Case Report and Review of the Literature

“…In addition, according to various, sporadic reports, multiple myeloma is occasionally associated with other peripheral T-cell lymphoma subtypes, including cutaneous anaplastic large T-cell lymphoma, Sezary syndrome, mycosis fungoides, and primary T-cell lymphoma of the bone (Bryant et al 1982;Weiss et al 1984;Brumana et al 1993;Cartron et al 1999;Wickenhauser et al 1999;Takami and Mizunoya 2000;Gernone et al 2002;Hwang et al 2008;Tangour et al 2011). In general, the secondary myeloma occurs several years after the initial diagnosis and the subsequent treatment of the T-cell lymphoma (Bryant et al 1982;Weiss et al 1984;Brumana et al 1993;Wickenhauser et al 1999;Gernone et al 2002;Zettl et al 2002;Hwang et al 2008).…”

“…In general, the secondary myeloma occurs several years after the initial diagnosis and the subsequent treatment of the T-cell lymphoma (Bryant et al 1982;Weiss et al 1984;Brumana et al 1993;Wickenhauser et al 1999;Gernone et al 2002;Zettl et al 2002;Hwang et al 2008). Various authors have suggested that the secondary neoplasms are potentially related to immunoregulatory disturbances caused by the primary lymphomas and that the malignant plasma cells may evolve from a sustained inducing stimulus provided by the neoplastic T cells.…”