Cutaneous T-Cell Lymphoid Dyscrasia

Evaluation of the International Society for Cutaneous Lymphoma Algorithm for the Diagnosis of Early Mycosis Fungoides

“…Notably, TCR-β clonality was not identified in any non-MF cases, therefore we believe that TCR-β clonality has 100% specificity in early MF. TCR rearrangements were also detected in 4 out of 22 non-MF cases in this study, which are presumed to be persistent cutaneous inflammatory infiltrates of monoclonal or oligoclonal T-cells due to conditions secondary to autoimmune or iatrogenic immune dysregulation and chronic idiopathic dermatoses [18][19][20].…”

Evaluation of the International Society for Cutaneous Lymphoma Algorithm for the Diagnosis of Early Mycosis Fungoides

“…Notably, TCR-β clonality was not identified in any non-MF cases, therefore we believe that TCR-β clonality has 100% specificity in early MF. TCR rearrangements were also detected in 4 out of 22 non-MF cases in this study, which are presumed to be persistent cutaneous inflammatory infiltrates of monoclonal or oligoclonal T-cells due to conditions secondary to autoimmune or iatrogenic immune dysregulation and chronic idiopathic dermatoses [18][19][20].…”

Mycosis Fungoides Preceding Pityriasis Lichenoides et Varioliformis Acuta by Twelve Years in a Pediatric Patient

“…TCR gene rearrangements should be interpreted with caution because many benign dermatoses common in the pediatric patient can also harbor monoclonal T-cell populations, such as PLEVA and PLC. 12 In addition, the presence of TCR gene rearrangement had no impact on treatment outcomes in one case series. 13 The prognosis of pediatric MF appears better than that of adult MF, and the majority demonstrate clearance within 1 year of therapy, though relapse following initial disease remission is common.…”

“…TCR gene rearrangements should be interpreted with caution because many benign dermatoses common in the pediatric patient can also harbor monoclonal T-cell populations, such as PLEVA and PLC. 12 In addition, the presence of TCR gene rearrangement had no impact on treatment outcomes in one case series. 13…”

Mimicry unveiled: The challenging diagnosis of pigmented purpura‐like mycosis fungoides initially misdiagnosed as pigmented purpura

“…Similar to our case, there have been examples of PPD being clinically and histologically diagnosed before MF was histologically diagnosed. Guitart and Magro 13 pointed out a number of chronic illnesses, including PPD, that are connected to T‐cell clones. These ailments frequently did not fit the diagnostic criteria for MF, manifested without a clear cause, and were resistant to topical treatments.…”

Evaluation of the International Society for Cutaneous Lymphoma Algorithm for the Diagnosis of Early Mycosis Fungoides

“…Notably, TCR-β clonality was not identified in any non-MF cases, therefore we believe that TCR-β clonality has 100% specificity in early MF. TCR rearrangements were also detected in 4 out of 22 non-MF cases in this study, which are presumed to be persistent cutaneous inflammatory infiltrates of monoclonal or oligoclonal T-cells due to conditions secondary to autoimmune or iatrogenic immune dysregulation and chronic idiopathic dermatoses [18][19][20].…”

Mycosis Fungoides Preceding Pityriasis Lichenoides et Varioliformis Acuta by Twelve Years in a Pediatric Patient

“…TCR gene rearrangements should be interpreted with caution because many benign dermatoses common in the pediatric patient can also harbor monoclonal T-cell populations, such as PLEVA and PLC. 12 In addition, the presence of TCR gene rearrangement had no impact on treatment outcomes in one case series. 13 The prognosis of pediatric MF appears better than that of adult MF, and the majority demonstrate clearance within 1 year of therapy, though relapse following initial disease remission is common.…”

“…TCR gene rearrangements should be interpreted with caution because many benign dermatoses common in the pediatric patient can also harbor monoclonal T-cell populations, such as PLEVA and PLC. 12 In addition, the presence of TCR gene rearrangement had no impact on treatment outcomes in one case series. 13…”

Mimicry unveiled: The challenging diagnosis of pigmented purpura‐like mycosis fungoides initially misdiagnosed as pigmented purpura

“…Similar to our case, there have been examples of PPD being clinically and histologically diagnosed before MF was histologically diagnosed. Guitart and Magro 13 pointed out a number of chronic illnesses, including PPD, that are connected to T‐cell clones. These ailments frequently did not fit the diagnostic criteria for MF, manifested without a clear cause, and were resistant to topical treatments.…”

Evaluation of the International Society for Cutaneous Lymphoma Algorithm for the Diagnosis of Early Mycosis Fungoides

“…Notably, TCR-β clonality was not identified in any non-MF cases, therefore we believe that TCR-β clonality has 100% specificity in early MF. TCR rearrangements were also detected in 4 out of 22 non-MF cases in this study, which are presumed to be persistent cutaneous inflammatory infiltrates of monoclonal or oligoclonal T-cells due to conditions secondary to autoimmune or iatrogenic immune dysregulation and chronic idiopathic dermatoses [18][19][20].…”

Mycosis Fungoides Preceding Pityriasis Lichenoides et Varioliformis Acuta by Twelve Years in a Pediatric Patient

“…TCR gene rearrangements should be interpreted with caution because many benign dermatoses common in the pediatric patient can also harbor monoclonal T-cell populations, such as PLEVA and PLC. 12 In addition, the presence of TCR gene rearrangement had no impact on treatment outcomes in one case series. 13 The prognosis of pediatric MF appears better than that of adult MF, and the majority demonstrate clearance within 1 year of therapy, though relapse following initial disease remission is common.…”

“…TCR gene rearrangements should be interpreted with caution because many benign dermatoses common in the pediatric patient can also harbor monoclonal T-cell populations, such as PLEVA and PLC. 12 In addition, the presence of TCR gene rearrangement had no impact on treatment outcomes in one case series. 13…”

Mimicry unveiled: The challenging diagnosis of pigmented purpura‐like mycosis fungoides initially misdiagnosed as pigmented purpura

“…Similar to our case, there have been examples of PPD being clinically and histologically diagnosed before MF was histologically diagnosed. Guitart and Magro 13 pointed out a number of chronic illnesses, including PPD, that are connected to T‐cell clones. These ailments frequently did not fit the diagnostic criteria for MF, manifested without a clear cause, and were resistant to topical treatments.…”