1963
DOI: 10.1001/archderm.1963.01590150088016
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Cutaneous Syndromes Produced as Side Effects of Triparanol Therapy

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Cited by 76 publications
(13 citation statements)
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“…Perhaps the strongest evidence for a role of stratum corneum lipids in the modulation of stratum corneum desquamation derives from the observation that a number of scaling disorders occur in acquired or inherited defects of lipid metabolism. Ichthyosis, palmarplantar keratoderma, and acanthosis nigricans, occur as side effects of several drugs (26)(27)(28)(29) that interfere with cholesterol biosynthesis or lower serum cholesterol by as yet unknown mechanisms. As reported here, RXLI scales contain not only increased cholesterol sulfate, but also decreased free sterols, raising the possibility that the reduction of free sterols may also regulate desquamation in RXLI.…”
Section: Resultsmentioning
confidence: 99%
“…Perhaps the strongest evidence for a role of stratum corneum lipids in the modulation of stratum corneum desquamation derives from the observation that a number of scaling disorders occur in acquired or inherited defects of lipid metabolism. Ichthyosis, palmarplantar keratoderma, and acanthosis nigricans, occur as side effects of several drugs (26)(27)(28)(29) that interfere with cholesterol biosynthesis or lower serum cholesterol by as yet unknown mechanisms. As reported here, RXLI scales contain not only increased cholesterol sulfate, but also decreased free sterols, raising the possibility that the reduction of free sterols may also regulate desquamation in RXLI.…”
Section: Resultsmentioning
confidence: 99%
“…Hair loss, loss of hair colour and ichthyosis have been reported in patients receiving triparanol, which has been withdrawn from the market because of cataract induction (Winkelmann et al 1963). Clofibrate may occasionally produce hair loss and hair brittleness (Reeves & Maibach 1983).…”
Section: Antihyperlipidaemic Drugsmentioning
confidence: 99%
“…Secondary ichthyosis has been described as occurring in Hodgkin's disease [6][7][8], multiple myeloma [3,4], cancer of the breast [1,2], cancer of the lung [8], sarcoidosis [5], Ichthyosis can also follow the intake of certain drugs, such as triparanol [9].…”
Section: Discussionmentioning
confidence: 99%