Cutaneous pseudolymphoma in association with molluscum contagiosum in an elderly patient

Moreno‐Ramírez, D.; García-Escudero, Antonio; Ríos-Martín, Juan José; Herrera-Saval, A.; Camacho, Francisco

doi:10.1034/j.1600-0560.2003.00098.x

Cited by 43 publications

(31 citation statements)

References 10 publications

(16 reference statements)

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“…Primary cutaneous CD30+ positive lymphoproliferative T-cell disorders represent a spectrum ranging from lymphomatoid papulosis to anaplastic large cell lymphoma. 40 Recently, CD30 expression was described on variable numbers of cells in several benign dermatoses such as carbamazepine-28 and cefuroxime-induced 33 drug reactions, scabies, 16,24 gold acupuncture reactions, 20 atopic dermatitis, 15 verruca vulgaris, 11 molluscum contagiosum, 27 Milker's nodule, 32 and various other nonneoplastic cutaneous infiltrates, 6 including also cutaneous herpetic infections. 13 In our cases, CD30 positivity was observed in scattered atypical lymphocytes with large, hyperchromatic nuclei, unlike the clustered CD30+ atypical cells found in lymphomatoid papulosis.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic Features of Cutaneous Herpes Virus Infections (Herpes Simplex, Herpes Varicella/Zoster)

Leinweber

Kerl

Cerroni

2006

The American Journal of Surgical Pathology

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Cutaneous eruptions caused by herpes simplex 1/2 (HSV-1/2) and herpes varicella/zoster (VZV) represent common dermatoses. In some cases, they present with atypical clinical and/or histopathologic features, including presence of dense lymphoid infiltrates with atypical lymphocytes simulating cutaneous lymphomas. In this study, we reviewed the biopsy specimens of 65 patients (33 males, 32 females; mean age, 61.2 years; median age, 62 years; age range, 19-96 years) with cutaneous eruptions caused by HSV-1/2 or VZV. Histologic examination revealed several atypical findings, including presence of dense lymphoid infiltrates, angiotropism, and atypical lymphocytes simulating malignant lymphoma. Immunohistochemistry performed in 22 cases showed a predominant T-cell infiltrate, in the majority of cases with variable numbers of CD30+ and CD56+ cells. Two cases with a pseudolymphomatous appearance and small clusters of CD30+ cells revealed a monoclonal population of T lymphocytes by PCR analysis, underlying the difficulties in classifying some of these cases correctly. Our study indicates that cutaneous herpes infections can exhibit several atypical histopathologic, immunohistochemical, and molecular features, and that in given cases accurate clinicopathologic correlation and short-term follow-up controls are necessary for differentiation from cutaneous lymphomas.

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Section: Discussionmentioning

confidence: 99%

Histopathologic Features of Cutaneous Herpes Virus Infections (Herpes Simplex, Herpes Varicella/Zoster)

Leinweber

Kerl

Cerroni

2006

The American Journal of Surgical Pathology

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“…A single case report of skin nodule and EU-like lesion showing identical monoclonal TCR-γ gene rearrangement has been reported and accordingly the oral lesion is regarded as CD30+ T cell non-Hodgkin’s lymphoma (lymphomatoid papulosis). As large atypical CD30+ cells have been reported in a variety of conditions such as infections [40], parasitic [41] and inflammatory disorders [42], their presence in EU is regarded as a reactive process to yet undetermined antigen(s). …”

Section: Discussion and Reviewmentioning

confidence: 99%

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Abdel-Naser¹,

Tsatsou²,

Hippe³

et al. 2011

Dermatology

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Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in agreement with eosinophilic ulcer with predominant oligoclonal CD3+ and CD30+ T lymphocytes expressing the Epstein-Barr virus membrane protein. The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder.

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“…In rare instances, a delayed hypersensitivity response to the MC virus can trigger an intense infiltrate of atypical lymphocytes mimicking a lymphoma. 5 Flame figures have also been reported in conjunction with MC. 10 Initially described in Wells syndrome and typically seen in bullous pemphigoid, eczema, and urticaria, flame figures consist of dermal collagen fibers coated with eosinophilic granules, most likely representing a hypersensitivity response.…”

Section: Discussionmentioning

confidence: 85%

“…The lack of inflammatory response typical of MC is partly attributable to the lipid encasement surrounding the molluscum bodies. 5 In addition to the banal presentation of MC, pseudocystic, polypoid, and giant MC variants have been described. 6 It has been reported that up to 4% of MC cases have been seen in association with other lesions.…”

Section: Discussionmentioning

confidence: 98%

Purple Penile Papules

Calder¹,

Mathew²,

Morgan³

2007

The American Journal of Dermatopathology

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Molluscum contagiosum may present in a variety of clinical and pathologic guises. We present the clinicopathologic features of an unusual case that initially was misinterpreted as bowenoid papulosis. The relevant histologic attributes of this case include the presence of a violaceous hyperplastic squamous epithelium adjacent to the infected keratinocytes. The presence of this violaceous cytoplasmic staining should prompt a search for molluscum in the appropriate clinical context.

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Cutaneous pseudolymphoma in association with molluscum contagiosum in an elderly patient

Abstract: After ruling out systemic involvement, the patient was followed up for 2 years with no evidence of recurrence. We report this case to the best of our knowledge and discuss the literature about atypical clinical and histological presentations of MC.

Cited by 43 publications

References 10 publications

Histopathologic Features of Cutaneous Herpes Virus Infections (Herpes Simplex, Herpes Varicella/Zoster)

Histopathologic Features of Cutaneous Herpes Virus Infections (Herpes Simplex, Herpes Varicella/Zoster)

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Purple Penile Papules

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