Cutaneous paraneoplastic syndromes

McLean, D. I.

doi:10.1001/archderm.122.7.765

Cited by 41 publications

(38 citation statements)

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“…On the other hand, PEO was demonstrated to represent a true paraneoplastic phenomenon according to McLean’s criteria (i.e. onset after the development of cancer and parallel course between the cancer and the dermatosis [107]) in only 3 of the patients for whom a detailed clinical history was available [34,49,52] and possibly in another 3 [31,39,81]. …”

Section: Discussionmentioning

confidence: 99%

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Torchia

Miteva

et al. 2010

Dermatology

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Background: Even after the description of papuloerythroderma of Ofuji (PEO) in 1984, little is known about this clinical entity. Objective:To report on 2 new cases of PEO and review of the worldwide literature on this topic. Methods: Article citations were searched on several biomedical search engines (PubMed, EMBASE, SCOPUS, Google Scholar). Papers were retrieved either online or in print. Results: A grand total of 170 PEO cases were identified. Most patients were older than 55 years and of Asian or white descent, with an overall male/female ratio of 4.0. Itch and the deck-chair sign were observed in all patients. Peripheral eosinophilia, lymphocytopenia and increased serum IgE were common findings. Histopathology mostly showed aspecific inflammation, while 17 showed histological features of cutaneous T-cell lymphoma (CTCL). Atopy, malignancies, infections and drugs were rarely linked to PEO. Conclusion: PEO represents a rather monomorphous entity both clinically and, with the remarkable exception of CTCL, also histologically. Nonetheless, no causative factor could be identified in the vast majority of cases. An etiological classification and diagnostic criteria are proposed in the attempt to contribute framing this puzzling clinical entity.

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Section: Discussionmentioning

confidence: 99%

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Torchia

Miteva

et al. 2010

Dermatology

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“…The diagnosis of chronic paraneoplastic syndromes usually requires two criteria: first, the simultaneous appearance of both skin eruption and neoplasms, and second, their parallel course[ 4]. However, it may also precede the clinical presentation of malignancy by many years [5].…”

Section: Discussionmentioning

confidence: 99%

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Nemets¹,

Ronen

Lugassy³

2006

Acta Haematol

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Mantle cell lymphoma (MCL) is an aggressive type of malignant lymphoma with short median survival despite conventional therapy. We describe the unusual case of a 66-year-old man with a chronic skin rash which preceded the occurrence of an indolent MCL by 2 years. Repeated skin biopsies did not show involvement by the lymphoma. Short therapy with rituximab resulted in the complete and lasting resolution of the cutaneous lesions.

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“…Indeed, EC evolution strongly paralleled that of lymphoma in 9 of 10 detailed cases, with simultaneous diagnosis, disappearance and relapse of both conditions, including three simultaneous consecutive relapses in the same patient. These characteristics, which are the hallmark of a true paraneoplastic syndrome [31,32,33,34,35], suggest that generalized EC should be added to the list of cutaneous paraneoplastic syndromes [36, 37]. In our series, we observed a paraneoplastic evolution in 20 patients.…”

Section: Discussionmentioning

confidence: 57%

Predictive Clinical Features of Eczema Craquelé Associated with Internal Malignancy

Sparsa¹,

Boulinguez²,

Liozon³

et al. 2007

Dermatology

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Objective: To describe a series of hospitalized patients with eczema craquelé (EC) and the possible correlations between clinical features of EC and cancer in an open prospective observational study. Patients and Interventions: The study population comprised 68 consecutive patients included between January 1, 1999 and December 31, 2000 who were followed up through December 2004. All patients who had localized or generalized EC were included. Patients underwent complete clinical examinations, routine laboratory tests, chest x-rays, abdominal ultrasound, and cutaneous biopsies performed on EC. Main Outcome Measures and Results: Rates of EC associated with cancer, clinical features of eczema, rate of recalcitrant eczema, relationship to other clinical prognostic factors, and paraneoplastic evolution were evaluated. Cancer was diagnosed in 32 patients (47%). We observed a significant difference in the presenting clinical signs of EC between patients with malignant tumors and patients without cancer. In patients with malignancies, EC was widespread on the trunk and we noted deep red and inflammatory fissures. In all cases, EC led to the discovery of malignancy or recurrence of cancer. Conclusion: Widespread EC, topical corticosteroid resistance, and deep red and inflammatory fissures were significantly correlated with neoplasia.

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Cutaneous paraneoplastic syndromes

Cited by 41 publications

References 0 publications

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Predictive Clinical Features of Eczema Craquelé Associated with Internal Malignancy

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