Cutaneous ossification in pseudohypoparathyroidism

Barranco, V. P.

doi:10.1001/archderm.104.6.643

Cited by 10 publications

(6 citation statements)

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“…This bone formation is secondary ossification or osseous metaplasia. It may be seen in association with cutaneous tumours, scars, or inflammatory process (Barranco, 1971). Bone tissue formation was also seen in the present case and was considered to be secondary to stromal tissue of the tumour.…”

supporting

confidence: 66%

Cutaneous myelolipoma in a peach‐faced lovebird(Agapornis roseicollis)

Ozakt

Kinoshita²,

Kurasho³

et al. 1996

Avian Pathology

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supporting

confidence: 66%

Cutaneous myelolipoma in a peach‐faced lovebird(Agapornis roseicollis)

Ozakt

Kinoshita²,

Kurasho³

et al. 1996

Avian Pathology

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“…Cutaneous and subcutaneous ossification is a well‐recognized, although variable, feature of Albright hereditary osteodystrophy (AHO), (21,22) but the children we evaluated had no other morphological manifestations of AHO or any evidence of hypocalcemia, pseudohypoparathyroidism, hypothyroidism, or hormone resistance (23–29) . Moreover, no family member of an affected child suffered from AHO or pseudohypoparathyroidism.…”

Section: How Was Poh Discovered?mentioning

confidence: 99%

“…AHO is an autosomal dominant disorder of the skin, skeletal, and endocrine systems, with variable features that may include pseudohypoparathyroidism, multiple hormone resistance, obesity, brachydactyly (especially fourth and fifth metacarpals), short stature, round facies, and cutaneous and subcutaneous ossification (Table 1). (22–26,28,58–70) Although patients with POH do not show the developmental dysmorphologies and hormone resistance that commonly are associated with AHO, cutaneous and subcutaneous ossification of the skin in childhood is rare, and therefore the possibility that the heterotopic ossification in these two conditions might involve the same cellular pathways is a reasonable consideration.…”

Section: Do Aho and G Proteins Hold A Clue To The Pathogenesis Of Poh?mentioning

confidence: 99%

Progressive Osseous Heteroplasia

Kaplan

Shore

2000

Journal of Bone and Mineral Research

204

147

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Progressive osseous heteroplasia (POH) is a recently described genetic disorder of mesenchymal differentiation characterized by dermal ossification during infancy and progressive heterotopic ossification of cutaneous, subcutaneous, and deep connective tissues during childhood. The disorder can be distinguished from fibrodysplasia ossificans progressiva (FOP) by the presence of cutaneous ossification, the absence of congenital malformations of the skeleton, the absence of inflammatory tumorlike swellings, the asymmetric mosaic distribution of lesions, the absence of predictable regional patterns of heterotopic ossification, and the predominance of intramembranous rather than endochondral ossification. POH can be distinguished

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“…E XTRASKELETAL OSSIFICATION (ectopic or heterotopic bone formation) occurs in several rare conditions including osteoma cutis, progressive osseous heteroplasia (POH), and Albright hereditary osteodystrophy (AHO) (1–2) . Ectopic ossification typically extends into deep muscle and fascia in POH, (3–7) whereas it is limited to superficial tissues in AHO (8–12) . Additionally, patients with POH do not have endocrinopathy or somatic features of AHO (3–7) .…”

Section: Introductionmentioning

confidence: 99%

Deficiency of the α-Subunit of the Stimulatory G Protein and Severe Extraskeletal Ossification

Eddy

Beur

Yandow

et al. 2000

Journal of Bone and Mineral Research

120

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Progressive osseous heteroplasia (POH) is a rare disorder characterized by dermal ossification beginning in infancy followed by increasing and extensive bone formation in deep muscle and fascia. We describe two unrelated girls with typical clinical, radiographic, and histological features of POH who also have findings of another uncommon heritable disorder, Albright hereditary osteodystrophy (AHO). One patient has mild brachydactyly but no endocrinopathy, whereas the other manifests brachydactyly, obesity, and target tissue resistance to thyrotropin and parathyroid hormone (PTH). Levels of the ␣-subunit of the G protein (G s ␣) were reduced in erythrocyte membranes from both girls and a nonsense mutation (Q12X) in exon 1 of the GNAS1 gene was identified in genomic DNA from the mildly affected patient.

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Cutaneous ossification in pseudohypoparathyroidism

Cited by 10 publications

References 0 publications

Cutaneous myelolipoma in a peach‐faced lovebird(Agapornis roseicollis)

Cutaneous myelolipoma in a peach‐faced lovebird(Agapornis roseicollis)

Progressive Osseous Heteroplasia

Deficiency of the α-Subunit of the Stimulatory G Protein and Severe Extraskeletal Ossification

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