Cutaneous Manifestations of Infectious Diseases

Miró, Elena Montalván; Sánchez, Néstor P.

doi:10.1007/978-1-4614-0688-4_7

Cited by 9 publications

(6 citation statements)

References 118 publications

(174 reference statements)

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“…Coexisting factors: The appearance of cutaneous signs can also be influenced by other concurrent health conditions an individual may have or medications they are taking. These coexisting factors can modify how malnutrition-related manifestations present on the skin, further complicating the diagnostic process and necessitating a thorough medical history assessment [ 48 ].…”

Section: Reviewmentioning

confidence: 99%

Unveiling Skin Manifestations: Exploring Cutaneous Signs of Malnutrition in Eating Disorders

Wani,

Chakole,

Agrawal

et al. 2023

Cureus

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The intricate interplay between eating disorders, malnutrition, and their cutaneous manifestations is the focal point of this comprehensive review. The review delves into the clinical significance of recognising and understanding these visible signs in the context of eating disorders. It highlights the vital role of nutrition in maintaining healthy skin and addresses the challenges associated with relying solely on cutaneous signs for diagnosis. Emphasising a multidisciplinary approach involving dermatologists, psychiatrists, and nutritionists, the review underscores the holistic nature of the treatment. Addressing psychological aspects alongside nutritional rehabilitation is underscored with a forward-looking perspective on future research avenues. This review is valuable for healthcare professionals by synthesising existing knowledge and identifying research gaps. It aims to improve the diagnosis, treatment, and preventative strategies for individuals dealing with the complex challenges of eating disorders and malnutrition.

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Section: Reviewmentioning

confidence: 99%

Unveiling Skin Manifestations: Exploring Cutaneous Signs of Malnutrition in Eating Disorders

Wani,

Chakole,

Agrawal

et al. 2023

Cureus

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“…The lesions are generally induced by external factors, such as surgery, mechanic impact, heat, cold, chemicals, and biological factors, including blood supply disorders, diabetes, and leishmaniosis [ 5 , 6 , 7 ]. Hindering the healing process, infections are hazardous to tissue, and delay tissue restoration, increasing expenses, treatment duration, and the risk of complications [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

et al. 2023

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Wounds are alterations in skin integrity resulting from any type of trauma. The healing process is complex, involving inflammation and reactive oxygen species formation. Therapeutic approaches for the wound healing process are diverse, associating dressings and topical pharmacological agents with antiseptics, anti-inflammatory, and antibacterial actions. Effective treatment must maintain occlusion and moisture in the wound site, suitable capacity for the absorption of exudates, gas exchange, and the release of bioactives, thus stimulating healing. However, conventional treatments have some limitations regarding the technological properties of formulations, such as sensory characteristics, ease of application, residence time, and low active penetration in the skin. Particularly, the available treatments may have low efficacy, unsatisfactory hemostatic performance, prolonged duration, and adverse effects. In this sense, there is significant growth in research focusing on improving the treatment of wounds. Thus, soft nanoparticles-based hydrogels emerge as promising alternatives to accelerate the healing process due to their improved rheological characteristics, increased occlusion and bioadhesiveness, greater skin permeation, controlled drug release, and a more pleasant sensory aspect in comparison to conventional forms. Soft nanoparticles are based on organic material from a natural or synthetic source and include liposomes, micelles, nanoemulsions, and polymeric nanoparticles. This scoping review describes and discusses the main advantages of soft nanoparticle-based hydrogels in the wound healing process. Herein, a state-of-the-art is presented by addressing general aspects of the healing process, current status and limitations of non-encapsulated drug-based hydrogels, and hydrogels formed by different polymers containing soft nanostructures for wound healing. Collectively, the presence of soft nanoparticles improved the performance of natural and synthetic bioactive compounds in hydrogels employed for wound healing, demonstrating the scientific advances obtained so far.

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“…Staphylococcus aureus , a Gram-positive bacterium, is both a human pathogen and part of the normal flora. S. aureus causes various infections, including skin and deep tissue infections (boils, carbuncles, furuncles, wound infections, folliculitis, bullous or pustular impetigo, scalded skin syndrome, cellulitis, necrotizing fasciitis), 1 - 5 urinary tract infections, 4 bacterial conjunctivitis, osteomyelitis and nosocomial infections such as surgical wound infections, lower respiratory tract infections and medical implant infections. 6 It can also cause toxin-associated poisoning through enterotoxin called staphylococcal food poisoning.…”

Section: Introductionmentioning

confidence: 99%

Genotypically Confirmed Vancomycin-Resistant Staphylococcus aureus With vanB Gene Among Clinical Isolates in Kathmandu

Nepal,

Mahara,

Subedi

et al. 2023

Microbiol�Insights

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Purpose: Methicillin-resistant Staphylococcus aureus, a common bacterial pathogen causes various infections. The acquisition of various antimicrobial-resistant genes in S. aureus has led to the transformation of this bacterium into a superbug. Vancomycin resistance among MRSA isolates is an emerging threat in empirical therapy of various infections. The study was hence aimed to find out the susceptibility status of S. aureus isolates toward vancomycin and detect mecA, vanA, and vanB genes among the isolates. Methods: A total of 1245 clinical samples from the participants attending a tertiary care hospital in Kathmandu were processed. S. aureus isolated from the samples were subjected to antibiotic susceptibility patterns using the modified Kirby-Bauer disk diffusion method. Agar dilution method was used to determine the minimum inhibitory concentration of vancomycin. The antibiotic-resistant genes such as mecA, vanA, and vanB among S. aureus isolates were screened by a conventional polymerase chain reaction. Results: Of 1245 samples, 80 S. aureus were identified. Out of which, 47.5% (38/80) were phenotypically confirmed MRSA isolates. mecA gene was detected in 84.2% (32/38) of MRSA isolates. 10.5% (4/38) were confirmed as vancomycin-intermediate S. aureus (VISA) by MIC determination. None of the isolates was positive for the vanA gene; however, 2 isolates were found to possess the vanB gene. The 2 isolates have vancomycin MIC breakpoints of 4 to 8 μg/mL. Conclusion: There might be a spreading of vancomycin resistance among S. aureus, creating serious public health problems. Therefore, measures to limit vancomycin resistance should be considered in healthcare facilities as immediately as possible.

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Cutaneous Manifestations of Infectious Diseases

Cited by 9 publications

References 118 publications

Unveiling Skin Manifestations: Exploring Cutaneous Signs of Malnutrition in Eating Disorders

Unveiling Skin Manifestations: Exploring Cutaneous Signs of Malnutrition in Eating Disorders

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

Genotypically Confirmed Vancomycin-Resistant Staphylococcus aureus With vanB Gene Among Clinical Isolates in Kathmandu

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