Cutaneous manifestations in patients with chronic renal failure on hemodialysis

Udayakumar, Prabhu D.; Balasubramanian, S; Ramalingam, K. S.; Lakshmi, Chembolli; Srinivas, CR; Mathew, Anil C

doi:10.4103/0378-6323.25636

Cited by 127 publications

(99 citation statements)

References 11 publications

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“…It was seen in study done by Udaykumar et al 11 Cancerous and precancerous lesions were not seen in this study. It was seen in few patients in other studies.…”

mentioning

confidence: 49%

“…The survival of red blood cells is reduced by approximately one-third in HD patients. 11 Common nail changes seen in this study was leukonychia in 11 patients followed by Lindsay's nail in 6 patients, onycholysis in 4 patients and subungual hyperkeratosis in 3 patients. In other studies nail changes observed were leukonychia, koilonychia, subungual hyperkeratosis, onycholysis, Mees' lines, Muehrcke's lines, Beau's lines and splinter hemorrhage.…”

Section: -4mentioning

confidence: 99%

“…The neurophysiological hypothesis is considered to play an important role in CRF -associated pruritus. 10,11 Kyrle's disease was seen in 3 patients. In a study done by Sanai et al, Kyrle's disease was noted in 17% of the patients.…”

Section: -4mentioning

confidence: 99%

“…Cutaneous manifestations of pruritus include excoriations, prurigo nodularis and lichen simplex chronicus. 10,11 The etiology of pruritus in CRF is unknown; however, several hypotheses have been suggested. Immuno hypothesis considers uremic pruritus as an inflammatory systemic disease rather than a local skin disorder.…”

Section: -4mentioning

confidence: 99%

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A clinical study of cutaneous and mucosal manifestations in patients with chronic renal failure on hemodialysis

Rafeek

Karthikeyan

2017

Int J Res Dermatol

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Background: Chronic kidney disease is defined as presence of kidney damage, manifested by abnormal albumin excretion or decreased kidney function, quantified by measured or estimated glomerular filtration rate (GFR) that persists for more than 3 months.Chronic kidney disease is major health problem. Chronic kidney failure presents with an array of cutaneous manifestations. The objective of the present study was to determine the pattern of muco-cutaneous manifestations of chronic renal failure on hemodialysis.Methods: A cross sectional study done in the Dermatology & Nephrology OPD of Sri Manakula Vinayagar Medical College and Hospital from October 2014 to May 2016. About 38 consenting patients who fulfilled the inclusion criteria were chosen for the study. The demographic characteristics were included in the study and the clinical profile of the patient such as hematological investigation and renal function tests were assessed. KOH mount, skin biopsy, Woods lamp, Grams stain and culture & sensitivity were done if needed after getting informed consent from the patients.Results: The most common cutaneous manifestations in haemodialysis patients were xerosis and uraemic pruritus. Conclusions: Cutaneous manifestations like uraemic pruritus, Xerosis, Kyrle’s disease, infections, icthyosis & other lesions were seen with Xerosis beimg the most common feature. At least one cutaneous manifestation is found in all CRF patients.

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“…It was seen in study done by Udaykumar et al 11 Cancerous and precancerous lesions were not seen in this study. It was seen in few patients in other studies.…”

mentioning

confidence: 49%

Section: -4mentioning

confidence: 99%

Section: -4mentioning

confidence: 99%

Section: -4mentioning

confidence: 99%

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A clinical study of cutaneous and mucosal manifestations in patients with chronic renal failure on hemodialysis

Rafeek

Karthikeyan

2017

Int J Res Dermatol

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“…Yellowing of the skin may be seen due to the deposition of carotenoids and urochromes within the skin and subcutaneous tissue. Hyperpigmentation is most prominent in sun-exposed areas and is attributed to increase in skin melanin due to excessive beta-melanocyte stimulating hormone [4]. …”

Section: Nonspecific Skin Changesmentioning

confidence: 99%

Skin Examination: An Important Diagnostic Tool in Renal Failure Patients

Velde-Kossmann¹

2018

Blood Purif

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Renal failure is common in the United States with an estimated prevalence of 660,000 treated end-stage renal disease patients in 2015 [1]. Causes of renal failure are many, and complications from renal failure, underlying disease, and treatment are not infrequent. Examples of common skin manifestations include xerosis, pigmentary change, and nail dystrophies. Frequent disease-specific skin changes may be helpful in the diagnosis of primary disorders leading to renal disease or severity of disease including bullosis diabeticorum, sclerodactyly, or leukoctoclastic vasculitis. Some cutaneous changes, such as the multiple angiokeratomas of Fabry disease or the plexiform neurofibromas of neurofibromatosis, are pathognomonic of genetic disorders, which often lead to renal failure. Careful examination of the skin can provide crucial clues to diagnosis of renal failure causation and aid in monitoring complications.

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