Cutaneous malignant neoplasms in patients with renal transplants

Risk‐adjusted relationship between voriconazole utilization and non‐melanoma skin cancer among lung and heart/lung transplant patients

“…This study, although observational, was able to properly statistically control for a wealth of patient demographic characteristics, comorbidities, and drug utilization information. Older age, male gender, and level of sun exposure are well‐established independent risk factors for the development of NMSC , and the fact that our analysis confirmed this suggests that results from our multivariable model are valid. In addition, our model showed that history of COPD was associated with a nearly 3‐fold increase in risk of NMSC development.…”

“…Differences between Vadnerker et al. and our study could also be explained by the fact that we examined all NMSC cases and not just cases of SCC, although previous research suggests that a large majority of the NMSC cases are likely to be SCC in our patient population . Feist et al.…”

“…Moreover, results showed that a history of immune disorder was associated with >3.5‐fold increase in risk of NMSC development. This finding suggests that a history of immune dysfunction before lung transplantation may contribute to the risk of NMSC development independently of the increased risk from augmented post‐transplant immunosuppression pharmacotherapy , and should be confirmed in future studies. Moreover, future research should explore more in‐depth functional assessments of overall patient immune function — as we were limited only to ICD‐9 designations for determining patient immune status.…”

Risk‐adjusted relationship between voriconazole utilization and non‐melanoma skin cancer among lung and heart/lung transplant patients

“…This study, although observational, was able to properly statistically control for a wealth of patient demographic characteristics, comorbidities, and drug utilization information. Older age, male gender, and level of sun exposure are well‐established independent risk factors for the development of NMSC , and the fact that our analysis confirmed this suggests that results from our multivariable model are valid. In addition, our model showed that history of COPD was associated with a nearly 3‐fold increase in risk of NMSC development.…”

“…Differences between Vadnerker et al. and our study could also be explained by the fact that we examined all NMSC cases and not just cases of SCC, although previous research suggests that a large majority of the NMSC cases are likely to be SCC in our patient population . Feist et al.…”

“…Moreover, results showed that a history of immune disorder was associated with >3.5‐fold increase in risk of NMSC development. This finding suggests that a history of immune dysfunction before lung transplantation may contribute to the risk of NMSC development independently of the increased risk from augmented post‐transplant immunosuppression pharmacotherapy , and should be confirmed in future studies. Moreover, future research should explore more in‐depth functional assessments of overall patient immune function — as we were limited only to ICD‐9 designations for determining patient immune status.…”

Cutaneous and Oral Lesions in 32 Children After Renal Transplantation

“…The frequency of skin tumors is high in some series of adult kidney transplant recipients (2,26,27). In our young patients, the shorter observation time after the procedure and thus the shorter duration of immunosuppressive treatment, together with reduced exposure time to environmental (ultraviolet rays) and occupational risk factors, might well account for the absence of epitheliomas or other tumors.…”

Biologic Therapy and the Risk of Malignancy in Psoriasis

“…Psoriasis patients are at a higher risk than is the general public for the development of malignancies. 4,[10][11][12] The risk is elevated with increasing severity of the disease state. The association is strongest for lymphoproliferative malignancies and cutaneous malignancies.…”

Risk‐adjusted relationship between voriconazole utilization and non‐melanoma skin cancer among lung and heart/lung transplant patients

“…This study, although observational, was able to properly statistically control for a wealth of patient demographic characteristics, comorbidities, and drug utilization information. Older age, male gender, and level of sun exposure are well‐established independent risk factors for the development of NMSC , and the fact that our analysis confirmed this suggests that results from our multivariable model are valid. In addition, our model showed that history of COPD was associated with a nearly 3‐fold increase in risk of NMSC development.…”

“…Differences between Vadnerker et al. and our study could also be explained by the fact that we examined all NMSC cases and not just cases of SCC, although previous research suggests that a large majority of the NMSC cases are likely to be SCC in our patient population . Feist et al.…”

“…Moreover, results showed that a history of immune disorder was associated with >3.5‐fold increase in risk of NMSC development. This finding suggests that a history of immune dysfunction before lung transplantation may contribute to the risk of NMSC development independently of the increased risk from augmented post‐transplant immunosuppression pharmacotherapy , and should be confirmed in future studies. Moreover, future research should explore more in‐depth functional assessments of overall patient immune function — as we were limited only to ICD‐9 designations for determining patient immune status.…”

Cutaneous and Oral Lesions in 32 Children After Renal Transplantation

“…The frequency of skin tumors is high in some series of adult kidney transplant recipients (2,26,27). In our young patients, the shorter observation time after the procedure and thus the shorter duration of immunosuppressive treatment, together with reduced exposure time to environmental (ultraviolet rays) and occupational risk factors, might well account for the absence of epitheliomas or other tumors.…”

Biologic Therapy and the Risk of Malignancy in Psoriasis

“…Psoriasis patients are at a higher risk than is the general public for the development of malignancies. 4,[10][11][12] The risk is elevated with increasing severity of the disease state. The association is strongest for lymphoproliferative malignancies and cutaneous malignancies.…”

Risk‐adjusted relationship between voriconazole utilization and non‐melanoma skin cancer among lung and heart/lung transplant patients

“…This study, although observational, was able to properly statistically control for a wealth of patient demographic characteristics, comorbidities, and drug utilization information. Older age, male gender, and level of sun exposure are well‐established independent risk factors for the development of NMSC , and the fact that our analysis confirmed this suggests that results from our multivariable model are valid. In addition, our model showed that history of COPD was associated with a nearly 3‐fold increase in risk of NMSC development.…”

“…Differences between Vadnerker et al. and our study could also be explained by the fact that we examined all NMSC cases and not just cases of SCC, although previous research suggests that a large majority of the NMSC cases are likely to be SCC in our patient population . Feist et al.…”

“…Moreover, results showed that a history of immune disorder was associated with >3.5‐fold increase in risk of NMSC development. This finding suggests that a history of immune dysfunction before lung transplantation may contribute to the risk of NMSC development independently of the increased risk from augmented post‐transplant immunosuppression pharmacotherapy , and should be confirmed in future studies. Moreover, future research should explore more in‐depth functional assessments of overall patient immune function — as we were limited only to ICD‐9 designations for determining patient immune status.…”

Cutaneous and Oral Lesions in 32 Children After Renal Transplantation

“…The frequency of skin tumors is high in some series of adult kidney transplant recipients (2,26,27). In our young patients, the shorter observation time after the procedure and thus the shorter duration of immunosuppressive treatment, together with reduced exposure time to environmental (ultraviolet rays) and occupational risk factors, might well account for the absence of epitheliomas or other tumors.…”

Biologic Therapy and the Risk of Malignancy in Psoriasis

“…Psoriasis patients are at a higher risk than is the general public for the development of malignancies. 4,[10][11][12] The risk is elevated with increasing severity of the disease state. The association is strongest for lymphoproliferative malignancies and cutaneous malignancies.…”