Cutaneous Malignant Melanoma in Survivors of Heritable Retinoblastoma

Hereditary Retinoblastoma, Lipoma, and Second Primary Cancers

“…Individuals with hereditary retinoblastoma are prone to development of dysplastic nevi with progression to cutaneous melanoma (2,11). Similarly, lipomas in patients with hereditary retinoblastoma may represent a clinical marker of susceptibility to sarcomas and other cancers, even though malignant changes in lipomas appear to occur very rarely, and only isolated cases have been reported (4).…”

Hereditary Retinoblastoma, Lipoma, and Second Primary Cancers

“…Individuals with hereditary retinoblastoma are prone to development of dysplastic nevi with progression to cutaneous melanoma (2,11). Similarly, lipomas in patients with hereditary retinoblastoma may represent a clinical marker of susceptibility to sarcomas and other cancers, even though malignant changes in lipomas appear to occur very rarely, and only isolated cases have been reported (4).…”

Nonocular Second Primary Tumors After Retinoblastoma

“…56 Histology was not available for 2 cases: -The first (case 4) concerned the only pineal tumor of our series, with characteristic computed tomography (CT) features. This case will be discussed in more detail below.…”

Second primary tumors in patients with retinoblastoma a review of the literature

“…This mutation also appears to play a pathogenetic role in a substantial proportion of osteosarcomas and soft-tissue sarcoma^.^^-^^ Another important finding is the high incidence of malignant melanomas (7.4%) which do not appear to harbor R B I mutations. 27 In an overview of the literature regarding melanoma and retinoblastoma, Traboulsi et al 30 reported that cutaneous malignant melanoma accounts for about 7% (range 4.2%-14.3%) of SPT. Pineoblastomas, trilateral retinoblastomas of the pineal gland,31,3z do not meet the definition of SPT, because pineoblastomas cannot be distinguished histologically from primary tumor retinoblastomas.…”

Hereditary Retinoblastoma, Lipoma, and Second Primary Cancers

“…Individuals with hereditary retinoblastoma are prone to development of dysplastic nevi with progression to cutaneous melanoma (2,11). Similarly, lipomas in patients with hereditary retinoblastoma may represent a clinical marker of susceptibility to sarcomas and other cancers, even though malignant changes in lipomas appear to occur very rarely, and only isolated cases have been reported (4).…”

Nonocular Second Primary Tumors After Retinoblastoma

“…56 Histology was not available for 2 cases: -The first (case 4) concerned the only pineal tumor of our series, with characteristic computed tomography (CT) features. This case will be discussed in more detail below.…”

Second primary tumors in patients with retinoblastoma a review of the literature

“…This mutation also appears to play a pathogenetic role in a substantial proportion of osteosarcomas and soft-tissue sarcoma^.^^-^^ Another important finding is the high incidence of malignant melanomas (7.4%) which do not appear to harbor R B I mutations. 27 In an overview of the literature regarding melanoma and retinoblastoma, Traboulsi et al 30 reported that cutaneous malignant melanoma accounts for about 7% (range 4.2%-14.3%) of SPT. Pineoblastomas, trilateral retinoblastomas of the pineal gland,31,3z do not meet the definition of SPT, because pineoblastomas cannot be distinguished histologically from primary tumor retinoblastomas.…”

Hereditary Retinoblastoma, Lipoma, and Second Primary Cancers

“…Individuals with hereditary retinoblastoma are prone to development of dysplastic nevi with progression to cutaneous melanoma (2,11). Similarly, lipomas in patients with hereditary retinoblastoma may represent a clinical marker of susceptibility to sarcomas and other cancers, even though malignant changes in lipomas appear to occur very rarely, and only isolated cases have been reported (4).…”

Nonocular Second Primary Tumors After Retinoblastoma

“…56 Histology was not available for 2 cases: -The first (case 4) concerned the only pineal tumor of our series, with characteristic computed tomography (CT) features. This case will be discussed in more detail below.…”

Second primary tumors in patients with retinoblastoma a review of the literature

“…This mutation also appears to play a pathogenetic role in a substantial proportion of osteosarcomas and soft-tissue sarcoma^.^^-^^ Another important finding is the high incidence of malignant melanomas (7.4%) which do not appear to harbor R B I mutations. 27 In an overview of the literature regarding melanoma and retinoblastoma, Traboulsi et al 30 reported that cutaneous malignant melanoma accounts for about 7% (range 4.2%-14.3%) of SPT. Pineoblastomas, trilateral retinoblastomas of the pineal gland,31,3z do not meet the definition of SPT, because pineoblastomas cannot be distinguished histologically from primary tumor retinoblastomas.…”