Cutaneous lymphomas consist of a spectrum of nosologically different entities including mycosis fungoides and small plaque parapsoriasis

Burg, G.

doi:10.1001/archderm.132.5.567

Cited by 26 publications

(34 citation statements)

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“…But parapsoriasis is defined by some authors as a reactive inflammatory disease different from mycosis fungoides, whereas others understand parapsoriasis as an initial phase of mycosis fungoides. Transition between the histological picture of both diseases has been clearly described in the literature [30][31][32][33]. This is in accordance with the theory which suggests an existence of a biologic grey zone between nonneoplastic inflammatory dermatoses and MF [34].…”

Section: Relationship To Parapsoriasissupporting

confidence: 82%

Practical Aspects Regarding the Histopathological Diagnosis of Early Mycosis Fungoides

Tebeică¹,

Andrei

Zurac

et al. 2016

Romanian Journal of Internal Medicine

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Mycosis fungoides is the most common primary T-cell lymphoma of skin. The disease has a protean clinical and histological presentation in its early patch and plaque stages, when distinction from mimicking inflammatory dermatoses is difficult. Since no single criterion is specific enough, a reliable diagnosis in early stages requires integration of clinical, histopathological and molecular findings. In skin biopsies, the most helpful histologic features are the detection of atypical lymphocytes in the epidermis with minimal epidermal changes, basal alignment of lymphocytes along dermal-epidermal junction and formation of Pautrier microabscesses. An aberrant immunophenotype of T cells and molecular detection of a clonal T-cell population are factors that could allow a more specific diagnosis. This work recapitulates and discusses these features from a practical perspective.

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Section: Relationship To Parapsoriasissupporting

confidence: 82%

Practical Aspects Regarding the Histopathological Diagnosis of Early Mycosis Fungoides

Tebeică¹,

Andrei

Zurac

et al. 2016

Romanian Journal of Internal Medicine

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“…Lymphoma cells were suspended at 2 ϫ 10 6 cells per milliliter in warm assay medium (37°C), and 100 L cell suspension was added to the upper chamber of each Transwell chamber. The plates were incubated for 3 hours at 37°C in 10% CO 2 . The migrated cells in the lower chambers were collected, and the number of migrated cells was counted by acquisition for 60 seconds with a flow cytometer.…”

Section: Migration Assaymentioning

confidence: 99%

“…[2][3][4] Primary cutaneous CD30 ϩ large-cell (anaplastic) CTCLs lack the t(2;5) translocation (NPM/ALK Ϫ ) and have a significantly better prognosis than systemic CD30 ϩ large-cell anaplastic lymphomas. 5 Expression of CD30 is not specific for systemic large-cell anaplastic lymphoma, and identification of abnormally expressed anaplastic large-cell lymphoma kinase 1 (ALK-1) is favored.…”

Section: Introductionmentioning

confidence: 99%

Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma

Kleinhans

Tun-Kyi

Gilliet

et al. 2003

Blood

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“…In particular, the condition known as chronic superficial scaly dermatitis or digitate dermatosis in the past has been diagnosed wrongly on clinical grounds as early or patch stage MF; this condition has also been referred to by some investigators as small-plaque parapsoriasis [16]. The term ‘large-plaque parapsoriasis’ has been applied to skin lesions that often represent the earliest stages of MF [2].…”

Section: Diagnostic Criteriamentioning

confidence: 99%

Mycosis fungoides: Review of Epidemiological Observations

Suárez-Varela¹,

González²,

Vila

et al. 2000

Dermatology

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Background: Mycosis fungoides (MF) is a chronic cutaneous T-cell lymphoma characterized by small cells with cerebriform nuclei that usually express a mature peripheral T-helper cell (CD4+) immunophenotype. Its evolution is typically quite slow, with years between the first manifestations and development of advanced stages of disease. Objective: The purpose of the present paper is to contribute to the material about MF already present in the literature. The review articles that have appeared to date fundamentally address the morphological characteristics, diagnostic criteria and treatment of the disease; in contrast, the present study centers on the evolution of the incidence of MF and on the knowledge of the possible risk factors implicated in its development. Methods: Review of published papers about MF epidemiology. Results: The evidence suggests that the incidence is increasing, but this may be artifactual due to improved diagnostic techniques. The risk of MF is limited to gender and race, being higher in males and in blacks. Survival is highly stage dependent, but 90% of patients survive 15 years with only 10% of cutaneous involvement. Few risk factors have been identified, but several studies have found an association with industrial exposure, particularly to oils. Conclusion: MF is a rare disease and its risk factors have not been studied in any great detail. A European case-control study in progress will substantially increase the evidence available and progress towards identifying a prevention strategy.

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Cutaneous lymphomas consist of a spectrum of nosologically different entities including mycosis fungoides and small plaque parapsoriasis

Cited by 26 publications

References 0 publications

Practical Aspects Regarding the Histopathological Diagnosis of Early Mycosis Fungoides

Practical Aspects Regarding the Histopathological Diagnosis of Early Mycosis Fungoides

Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma

Mycosis fungoides: Review of Epidemiological Observations

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