Cutaneous lupus erythematosus: First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)

Biazar, Cyrus; Sigges, Johanna; Patsinakidis, Nikolaos; Ruland, Vincent; Amler, Susanne; Bonsmann, Gisela; Kuhn, Annegret; Haust, Merle; Nyberg, Filippa; Bata, Zsuzsanna; Mihályi, Lilla; Olteanu, Rodica; Pujol, Ramón M.; Sánchez‐Schmidt, Julia M.; Medenica, Ljiljana; Škiljević, Dušan; Reich, Adam; Szepietowski, Jacek C.; Vedove, Camilla Dalle; Girolomoni, Giampiero; Hawro, Tomasz; Zalewska-Janowska, Anna; Glaeser, R.; Huegel, Rainer; Jedličková, Hana; Bygum, Anette; Laurinaviciene, Rasa; Benoit, Sandrine; Broecker, E.‐B.; Bahmer, Friedrich A.; Aberer, Elisabeth; Wutte, Nora; Lipozenčić, Jasna; Marinović, Branka; Sárdy, Miklós; Bekou, Vassiliki; Ruzicka, Thomas; Françès, Camille; Soutou, Boutros; Lee, H.; Worm, Margitta; Gruschke, A.; Hunzelmann, Nicolas; Steinbrink, Kerstin; Romiti, Ricardo; Sticherling, Michael; Erfurt‐Berge, Cornelia; Avgerinou, Georgia; Papafragkaki, Dafni; Antiga, Emiliano; Caproni, Marzia; Mayer, Benjamin; Volc‐Platzer, Beatrix; Kreuter, Alexander; Tigges, Christian; Heil, P.; Stingl, Georg

doi:10.1016/j.autrev.2012.08.019

Cited by 142 publications

(126 citation statements)

References 41 publications

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“…11,14,15 Similar observations in ACLE and CCLE were made by others. 7,10,16 LE-nonspecific skin lesions were seen exclusively in patients with SLE. The most common LE nonspecific lesion was non-scarring alopecia with predominant telogen effluvium.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Manifestations of Lupus Erythematosus From a Tertiary Care Centre in Coastal Kerala

James¹,

Nair²

2017

jemds

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BACKGROUNDThe aim of this study was to describe the Lupus Erythematosus (LE)-specific and LE-nonspecific cutaneous manifestations of lupus erythematosus. MATERIALS AND METHODSCutaneous manifestations of lupus erythematosus in forty consecutive patients with LE who attended Dermatology department from January 2014 to June 2015 were studied. RESULTSMajority of the patients included in the study were female (65%). The most common age group affected was 20-40 years (47.5%). Photosensitivity was the most common symptom (45%). Forty five percent of patients in the study were diagnosed of systemic lupus erythematosus (SLE) according to the ACR criteria. LE-specific skin lesions were more common than LE-nonspecific lesions (95% vs. 40%). Chronic Cutaneous LE (CCLE) was the most common LE-specific skin lesion (85%). Only psoriasiform type of Subacute Cutaneous LE (SCLE) lesions were seen in the study group. Malar rash was the most common Acute Cutaneous LE (ACLE) lesion (87.5%). Features suggestive of systemic involvement were most commonly found in patients with ACLE and least in those with CCLE. Most common LE nonspecific lesion was non-scarring alopecia (32.5%) due to telogen effluvium. Cutaneous vascular disease in the form of palpable purpura of leucocytoclastic vasculitis (2.5%), periungual telangiectasia (7.5%), erythema multiforme (2.5%) and leg ulcers (5%) were the other LE-nonspecific skin lesions observed in the study. Patients with LEnonspecific skin lesion had more systemic involvement compared to those without it. CONCLUSION LE-specific lesions are more common and can act as a diagnostic clue for lupus. LE-nonspecific lesions are more commonly associated with systemic disease.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Manifestations of Lupus Erythematosus From a Tertiary Care Centre in Coastal Kerala

James¹,

Nair²

2017

jemds

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“…In a recent multicentre database analysis of the European Society of Cutaneous Lupus Erythematosus, drug-induced cutaneous LE was shown to represent 6 % among 1,002 patients with cutaneous lesions and 13.2 % of those with the subacute variant of cutaneous LE (Biazar et al 2013 ). This form of drug-induced subacute cutaneous LE is usually associated with photosensitivity and mild systemic manifestations of LE.…”

Section: Drug-induced Cutaneous Lupus Erythematosusmentioning

confidence: 98%

Drug Photosensitivity

Gonçalo¹,

Giménez‐Arnau²

2015

European Handbook of Dermatological Treatments

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“…The detection of high titer levels varies by subtype. A recently published study on more than 1,000 patients examined the frequency of increased ANA titer levels [10]. Elevated ANA titers were found in more than 90 % of patients with 4 or more ACR criteria and in nearly 50 % of patients with less than 4 ACR criteria.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

Lupus erythematosus. Part II: Clinical picture, diagnosis and treatment

Ziemer

Milkova

Kunz

2014

J Deutsche Derma Gesell

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SummaryLupus erythematosus (LE) is an important dermatologic autoimmune disease. In many respects, it may be regarded as a model autoimmune disease due to its spectrum of autoimmune antibodies and involvement of different organ systems, as well as response to immunosuppressive agents which target B cells and T cells and their cytokines. A recently published article in this Journal summarized the most important knowledge about epidemiology, genetics, and immunology of LE. Here, the different clinical manifestations, diagnostic procedures and current therapeutic approaches will be described. Special emphasis is placed on different cutaneous manifestations of LE. In regard to treatment, the classic treatment approaches such as corticosteroids, methotrexate, chloroquine and hydroxychloroquine will be described. Lastly, new therapeutic approaches with specific monoclonal antibodies which are currently used in systemic LE, such as belimumab (Benlysta®), will be addressed. The most recent developments in this area could have implications even for purely cutaneous forms of LE.

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Cutaneous lupus erythematosus: First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)

Cited by 142 publications

References 41 publications

Cutaneous Manifestations of Lupus Erythematosus From a Tertiary Care Centre in Coastal Kerala

Cutaneous Manifestations of Lupus Erythematosus From a Tertiary Care Centre in Coastal Kerala

Drug Photosensitivity

Lupus erythematosus. Part II: Clinical picture, diagnosis and treatment

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