Archives of Dermatology
 1994
DOI: 10.1001/archderm.130.4.494
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Cutaneous leukocyte trafficking and psoriasis

C.E.M. Griffiths1
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Cited by 11 publications

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“…S ir , The psoriatic process is mediated, at least in part, by immunological events including the trafficking of activated T lymphocytes and other inflammatory cells into the skin and the production of cytokines and growth factors by these cells and epidermal keratinocytes 1,2 . Cellular expression of intercellular adhesion molecules (ICAM), ligands for lymphocyte function‐associated antigen (LFA)‐1, is a prerequisite for cutaneous leucocyte trafficking 2 .…”
mentioning
confidence: 99%
“…S ir , The psoriatic process is mediated, at least in part, by immunological events including the trafficking of activated T lymphocytes and other inflammatory cells into the skin and the production of cytokines and growth factors by these cells and epidermal keratinocytes 1,2 . Cellular expression of intercellular adhesion molecules (ICAM), ligands for lymphocyte function‐associated antigen (LFA)‐1, is a prerequisite for cutaneous leucocyte trafficking 2 . ICAM‐1 expression is up‐regulated on endothelial cells and induced on keratinocytes by interferon‐γ and tumour necrosis factor (TNF)‐α, 3 whereas ICAM‐3 is constitutively expressed on lymphocytes and Langerhans' cells but not on keratinocytes 4,5 .…”
mentioning
confidence: 99%
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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…S ir , The psoriatic process is mediated, at least in part, by immunological events including the trafficking of activated T lymphocytes and other inflammatory cells into the skin and the production of cytokines and growth factors by these cells and epidermal keratinocytes 1,2 . Cellular expression of intercellular adhesion molecules (ICAM), ligands for lymphocyte function‐associated antigen (LFA)‐1, is a prerequisite for cutaneous leucocyte trafficking 2 .…”
mentioning
confidence: 99%
“…S ir , The psoriatic process is mediated, at least in part, by immunological events including the trafficking of activated T lymphocytes and other inflammatory cells into the skin and the production of cytokines and growth factors by these cells and epidermal keratinocytes 1,2 . Cellular expression of intercellular adhesion molecules (ICAM), ligands for lymphocyte function‐associated antigen (LFA)‐1, is a prerequisite for cutaneous leucocyte trafficking 2 . ICAM‐1 expression is up‐regulated on endothelial cells and induced on keratinocytes by interferon‐γ and tumour necrosis factor (TNF)‐α, 3 whereas ICAM‐3 is constitutively expressed on lymphocytes and Langerhans' cells but not on keratinocytes 4,5 .…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Leucocyte function associated antigens (LFA) are adhesion molecule ligands essential for cutaneous lymphocyte migration, adhesion and activation 17 . An IgG‐LFA‐3 fusion protein (Amevive®, Biogen) which blocks T‐cell binding (via CD2) to LFA‐3 on antigen‐presenting cells has been shown to be an effective and seemingly safe therapy for psoriasis in vehicle‐controlled studies and is currently undergoing phase III trials 18 .…”
Section: Immunologymentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In psoriasis, the integrin expression pattern of keratinocytes and infiltrate cells is altered. [21][22][23][24][25] In normal keratinocytes of the epidermis, integrin expression is confined to the basal (proliferative) layer, whereas in hyperproliferative conditions, such as psoriasis, integrins are also expressed on suprabasal keratinocytes. On psoriatic infiltrate cells, some integrins show overexpression, whereas others are downregulated.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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