Cutaneous insulin reaction resembling acanthosis nigricans

Drug‐induced acanthosis nigricans: A systematic review and new classification

“…Erickson et al 27 reported a peculiar cutaneous eruption to repeated insulin injections for 2 years. The first case report identifying insulin injections as a cause of AN was by Fleming and Simon 26 . This occurred in a 57‐year‐old diabetic man who self‐administered insulin suspension to two sites.…”

Drug‐induced acanthosis nigricans: A systematic review and new classification

“…Erickson et al 27 reported a peculiar cutaneous eruption to repeated insulin injections for 2 years. The first case report identifying insulin injections as a cause of AN was by Fleming and Simon 26 . This occurred in a 57‐year‐old diabetic man who self‐administered insulin suspension to two sites.…”

Acanthosis nigricans in a plaque of scleredema on the back of a diabetic patient: A case report

“…Acanthosis nigricans has also been associated with certain medications such as nicotinic acid, triazinate, glucocorticoids, oral contraceptives, diethylstilbestrol, and testosterone 2,5 . Acanthosis nigricans can also develop at insulin injection sites 6 . It is therefore a useful cutaneous marker that should be evaluated carefully because its management is determined by its specific cause.…”

Differential diagnosis of melasma and hyperpigmentation

“…29 Multiple medications have also been linked to acanthosis nigricans, these include nicotinic acid, systemic glucocorticoids, diethylstilboestrol, combined oral contraceptive pill, estrogen, growth hormone therapy, protease inhibitors, niacin, and injected insulin. 7,30,31 The pathogenesis of acanthosis nigricans is thought to be related to growth factor levels and insulin-mediated activation of insulin-like growth factors on keratinocytes and increased growth factor levels. This activation triggers the proliferation of fibroblasts and the enhanced stimulation of epidermal keratinocytes.…”

“…The malar pattern is restricted to the malar cheeks on the face and can include the nose (Figure 1B), while mandibular melasma is present on the ramus of the mandible (jawline) and may include the chin 5,6 . The mandibular pattern of melasma tends to be noted in postmenopausal women 4,7 …”

“…This subtype of acanthosis nigricans is typically rapid in onset and may precede, accompany or follow the onset of internal malignancy 29 . Multiple medications have also been linked to acanthosis nigricans, these include nicotinic acid, systemic glucocorticoids, diethylstilboestrol, combined oral contraceptive pill, estrogen, growth hormone therapy, protease inhibitors, niacin, and injected insulin 7,30,31 . The pathogenesis of acanthosis nigricans is thought to be related to growth factor levels and insulin‐mediated activation of insulin‐like growth factors on keratinocytes and increased growth factor levels.…”

Drug‐induced acanthosis nigricans: A systematic review and new classification

“…Erickson et al 27 reported a peculiar cutaneous eruption to repeated insulin injections for 2 years. The first case report identifying insulin injections as a cause of AN was by Fleming and Simon 26 . This occurred in a 57‐year‐old diabetic man who self‐administered insulin suspension to two sites.…”

Acanthosis nigricans in a plaque of scleredema on the back of a diabetic patient: A case report

“…Acanthosis nigricans has also been associated with certain medications such as nicotinic acid, triazinate, glucocorticoids, oral contraceptives, diethylstilbestrol, and testosterone 2,5 . Acanthosis nigricans can also develop at insulin injection sites 6 . It is therefore a useful cutaneous marker that should be evaluated carefully because its management is determined by its specific cause.…”

Differential diagnosis of melasma and hyperpigmentation

“…29 Multiple medications have also been linked to acanthosis nigricans, these include nicotinic acid, systemic glucocorticoids, diethylstilboestrol, combined oral contraceptive pill, estrogen, growth hormone therapy, protease inhibitors, niacin, and injected insulin. 7,30,31 The pathogenesis of acanthosis nigricans is thought to be related to growth factor levels and insulin-mediated activation of insulin-like growth factors on keratinocytes and increased growth factor levels. This activation triggers the proliferation of fibroblasts and the enhanced stimulation of epidermal keratinocytes.…”

“…The malar pattern is restricted to the malar cheeks on the face and can include the nose (Figure 1B), while mandibular melasma is present on the ramus of the mandible (jawline) and may include the chin 5,6 . The mandibular pattern of melasma tends to be noted in postmenopausal women 4,7 …”

“…This subtype of acanthosis nigricans is typically rapid in onset and may precede, accompany or follow the onset of internal malignancy 29 . Multiple medications have also been linked to acanthosis nigricans, these include nicotinic acid, systemic glucocorticoids, diethylstilboestrol, combined oral contraceptive pill, estrogen, growth hormone therapy, protease inhibitors, niacin, and injected insulin 7,30,31 . The pathogenesis of acanthosis nigricans is thought to be related to growth factor levels and insulin‐mediated activation of insulin‐like growth factors on keratinocytes and increased growth factor levels.…”

Drug‐induced acanthosis nigricans: A systematic review and new classification

“…Erickson et al 27 reported a peculiar cutaneous eruption to repeated insulin injections for 2 years. The first case report identifying insulin injections as a cause of AN was by Fleming and Simon 26 . This occurred in a 57‐year‐old diabetic man who self‐administered insulin suspension to two sites.…”

Acanthosis nigricans in a plaque of scleredema on the back of a diabetic patient: A case report

“…Acanthosis nigricans has also been associated with certain medications such as nicotinic acid, triazinate, glucocorticoids, oral contraceptives, diethylstilbestrol, and testosterone 2,5 . Acanthosis nigricans can also develop at insulin injection sites 6 . It is therefore a useful cutaneous marker that should be evaluated carefully because its management is determined by its specific cause.…”

Differential diagnosis of melasma and hyperpigmentation

“…29 Multiple medications have also been linked to acanthosis nigricans, these include nicotinic acid, systemic glucocorticoids, diethylstilboestrol, combined oral contraceptive pill, estrogen, growth hormone therapy, protease inhibitors, niacin, and injected insulin. 7,30,31 The pathogenesis of acanthosis nigricans is thought to be related to growth factor levels and insulin-mediated activation of insulin-like growth factors on keratinocytes and increased growth factor levels. This activation triggers the proliferation of fibroblasts and the enhanced stimulation of epidermal keratinocytes.…”

“…The malar pattern is restricted to the malar cheeks on the face and can include the nose (Figure 1B), while mandibular melasma is present on the ramus of the mandible (jawline) and may include the chin 5,6 . The mandibular pattern of melasma tends to be noted in postmenopausal women 4,7 …”

“…This subtype of acanthosis nigricans is typically rapid in onset and may precede, accompany or follow the onset of internal malignancy 29 . Multiple medications have also been linked to acanthosis nigricans, these include nicotinic acid, systemic glucocorticoids, diethylstilboestrol, combined oral contraceptive pill, estrogen, growth hormone therapy, protease inhibitors, niacin, and injected insulin 7,30,31 . The pathogenesis of acanthosis nigricans is thought to be related to growth factor levels and insulin‐mediated activation of insulin‐like growth factors on keratinocytes and increased growth factor levels.…”