Cutaneous histiocytoid hemangioma

Abstract

Three cases of Kimura's disease or angiolymphoid hyperplasia with eosinophilia without the characteristic inflammatory infiltrate are reported. These unusual variants support the contention that the common denominator of these vascular lesions, whether they occur in the skin or (more rarely) in extracutaneous sites, is a histiocytoid endothelial cell. Since the composition of the associated inflammatory cell infiltrate is highly variable, a more appropriate term for these lesions is "histiocytoid hemangioma."

Papular angiolymphoid hyperplasia and lymphoplasmacytic plaque: a clinical and histological spectrum

“…Having considered the above reasons why 'APACHE' may not be an accurate description of the condition, as well as the prominent histological similarities it shares with ALHE, we support the proposition by Chedraoui [14] that 'papular angiolymphoid hyperplasia' would be a more appropriate term. This overlap in clinical features was also previously recognized by Burrall and Barr [17] who reported three unusual cases of ALHE with its characteristic vascular proliferation of plump endothelial cells but an without its typical infiltrate and suggested that the common denominator of these "inflammatory angiomatoses" is that of the plump "histiocytoid" endothelial cell.…”

Papular angiolymphoid hyperplasia and lymphoplasmacytic plaque: a clinical and histological spectrum

“…Having considered the above reasons why 'APACHE' may not be an accurate description of the condition, as well as the prominent histological similarities it shares with ALHE, we support the proposition by Chedraoui [14] that 'papular angiolymphoid hyperplasia' would be a more appropriate term. This overlap in clinical features was also previously recognized by Burrall and Barr [17] who reported three unusual cases of ALHE with its characteristic vascular proliferation of plump endothelial cells but an without its typical infiltrate and suggested that the common denominator of these "inflammatory angiomatoses" is that of the plump "histiocytoid" endothelial cell.…”

Histiocytoid Hemangioma with Prominent Fingernail Involvement

“…However, the pathological features were typical for a diagnosis of histiocytoid hemangioma showing vascular proliferation characterized by enlarged endothelial cells associated with inflammatory cells. The phenotypic characterization of the proliferating cells confirmed their vascular origin [2][3][4]. Histiocytoid hemangioma is a rare distinctive clinicopathological entity that most commonly affects the head and ears but can occasionally be seen at other sites.…”

“…Histiocytoid hemangioma of the skin usually presents as solitary or mul tiple light-pink to red-brown papules, nodules or plaques. Lesions, which arc usually dome shaped, firm in consis tency and a little tender, have an angiomatous appearance that could even suggest pyogenic granuloma or Kaposi's sarcoma [3]. However, clinically they differ from pyogenic granuloma because they are sessile or plaque-like and ex hibit slow growth.…”

Angiolymphoid hyperplasia with eosinophilia of the auricle: progression of histopathological changes

“…There is controversy as to whether the condition is reactive or neoplastic. Burrall et al (1982) 8 postulated that the condition may initially be reactive, followed by neoplastic proliferation of stimulated endothelial cells. In vitro studies have demonstrated a direct antiproliferative effect of recombinant human interferon alpha, beta and gamma on human dermal microvascular endothelial cells.…”

Papular angiolymphoid hyperplasia and lymphoplasmacytic plaque: a clinical and histological spectrum

“…Having considered the above reasons why 'APACHE' may not be an accurate description of the condition, as well as the prominent histological similarities it shares with ALHE, we support the proposition by Chedraoui [14] that 'papular angiolymphoid hyperplasia' would be a more appropriate term. This overlap in clinical features was also previously recognized by Burrall and Barr [17] who reported three unusual cases of ALHE with its characteristic vascular proliferation of plump endothelial cells but an without its typical infiltrate and suggested that the common denominator of these "inflammatory angiomatoses" is that of the plump "histiocytoid" endothelial cell.…”

Histiocytoid Hemangioma with Prominent Fingernail Involvement

“…However, the pathological features were typical for a diagnosis of histiocytoid hemangioma showing vascular proliferation characterized by enlarged endothelial cells associated with inflammatory cells. The phenotypic characterization of the proliferating cells confirmed their vascular origin [2][3][4]. Histiocytoid hemangioma is a rare distinctive clinicopathological entity that most commonly affects the head and ears but can occasionally be seen at other sites.…”

“…Histiocytoid hemangioma of the skin usually presents as solitary or mul tiple light-pink to red-brown papules, nodules or plaques. Lesions, which arc usually dome shaped, firm in consis tency and a little tender, have an angiomatous appearance that could even suggest pyogenic granuloma or Kaposi's sarcoma [3]. However, clinically they differ from pyogenic granuloma because they are sessile or plaque-like and ex hibit slow growth.…”

Angiolymphoid hyperplasia with eosinophilia of the auricle: progression of histopathological changes

“…There is controversy as to whether the condition is reactive or neoplastic. Burrall et al (1982) 8 postulated that the condition may initially be reactive, followed by neoplastic proliferation of stimulated endothelial cells. In vitro studies have demonstrated a direct antiproliferative effect of recombinant human interferon alpha, beta and gamma on human dermal microvascular endothelial cells.…”

Papular angiolymphoid hyperplasia and lymphoplasmacytic plaque: a clinical and histological spectrum

“…Having considered the above reasons why 'APACHE' may not be an accurate description of the condition, as well as the prominent histological similarities it shares with ALHE, we support the proposition by Chedraoui [14] that 'papular angiolymphoid hyperplasia' would be a more appropriate term. This overlap in clinical features was also previously recognized by Burrall and Barr [17] who reported three unusual cases of ALHE with its characteristic vascular proliferation of plump endothelial cells but an without its typical infiltrate and suggested that the common denominator of these "inflammatory angiomatoses" is that of the plump "histiocytoid" endothelial cell.…”

Histiocytoid Hemangioma with Prominent Fingernail Involvement

“…However, the pathological features were typical for a diagnosis of histiocytoid hemangioma showing vascular proliferation characterized by enlarged endothelial cells associated with inflammatory cells. The phenotypic characterization of the proliferating cells confirmed their vascular origin [2][3][4]. Histiocytoid hemangioma is a rare distinctive clinicopathological entity that most commonly affects the head and ears but can occasionally be seen at other sites.…”

“…Histiocytoid hemangioma of the skin usually presents as solitary or mul tiple light-pink to red-brown papules, nodules or plaques. Lesions, which arc usually dome shaped, firm in consis tency and a little tender, have an angiomatous appearance that could even suggest pyogenic granuloma or Kaposi's sarcoma [3]. However, clinically they differ from pyogenic granuloma because they are sessile or plaque-like and ex hibit slow growth.…”

Angiolymphoid hyperplasia with eosinophilia of the auricle: progression of histopathological changes

“…There is controversy as to whether the condition is reactive or neoplastic. Burrall et al (1982) 8 postulated that the condition may initially be reactive, followed by neoplastic proliferation of stimulated endothelial cells. In vitro studies have demonstrated a direct antiproliferative effect of recombinant human interferon alpha, beta and gamma on human dermal microvascular endothelial cells.…”