Cutaneous haemangioendothelioma: a possible link with chronic exposure to vinyl chloride.

Abstract

A patient who worked with polyvinyl chloride developed a malignant haemangioendothelioma of a toe. This rare tumour is more commonly found in the liver where it has been reported to arise in association with exposure to the vinyl chloride monomer.

Metastatic Tumors to the Nail Unit: Subungual Metastases

“…The diagnosis of a subungual metastasis may not be considered initially by the clinician—especially when it occurs in a cancer‐free individual in whom a metastatic malignancy is not suspected. The clinical differential diagnosis of subungual metastases are listed in Table 4 1,3,6,8,9,12,13,15,16,23,25,28,31,35,36,43,50,52,56,58,60,74–99,106,110,112–135 . The clinical presentation of an erythematous tender swelling of a distal digit involving the nail folds, the subungual area, or both often resulted in the lesion initially being mistaken as an acute infection, such as an abscess, a felon, or a paronychia, with or without an underlying osteomyelitis.…”

“…BENIGN AND MALIGNANT TUMORS may originate in the nail unit. Malignant tumors represent either metastatic lesions from a neoplasm whose origin is not from the nail unit (Table 1), 1–73 cutaneous involvement of a hematopoietic or lymphoproliferative malignancy at this site, 74–79 or a primary cancer occurring at this location 3,8,23,43,50,52,56,74,80–99 . The clinical characteristics, radiographic changes, and pathologic findings of nail unit metastases in two women with metastatic carcinoma are described.…”

Cutaneous Epithelioid Hemangioendothelioma on the Sole of a Child

“…It generally affects middle‐aged patients and is extremely rare in childhood, with only five previously described cutaneous cases . The etiology of EHE remains unknown, although Dean et al suggested that the greater incidence of EHE of the liver in women might be related to oral contraceptive use, and Davies et al have also reported a possible relationship between chronic vinyl chloride exposure and EHE.…”

Femoral artery angiosarcoma presenting with distal embolization: Report of a case

“…It arises mostly on the intimal surface and proliferates into the lumen causing either vascular obstruction or distal embolization to lower extremities, viscera, kidneys, or brain. [1][2][3][4][5][6][7][8][9][10] Its etiology is still unknown and multiple risk factors including radiotherapy, chronic lymphoedema, 3,9 foreign bodies (Dacron or plastic graft materials), 1,3,7 or environmental carcinogens (polyvinyl chloride, Thorotrast) 13 have been implicated in the pathogenesis.…”