Cutaneous Focal Mucinosis

Solitary subcutaneous mucinosis surrounded by bizarre‐shaped, factor XIIIa‐positive cells with intranuclear vacuoles

“…In the process of making a diagnosis in our present case, two relevaiu mucinoses were considered. The first is CFM which, apart from tare multiple adult and juvenile cases, occurs as an asymptomatic solitary cutaneous nodule on the face, trunk, and extremities in middle-aged aditlts of either sex (1). A histological study shows a localized area in the dermis where collagen fibers are fragmented and replaced by variable amounts of mucin.…”

“…Primary mucinoses include generalized or localized myxedema, papular mucinosis, cutaneous focal mucinosis (CFM), and cutaneous (angio)-myxoma (CM). CFM and CM have been shown by some authors to represent distinct clinical and histological entities (1,2), whereas others speculated that they may be variants of the same disease (3,4). We describe here a solitary subcutaneous mucinosis in the cheek associated with unique histological features pardy resembling those of CFM and those of CM.…”

Fibromyxoma of the Skin

“…The ground mucinous substance consisted of hyaluronic acid, as in the present case. Because the presence of hyaluronic acid is not necessarily specific, this tumor must be differentiated from other mesenchymal neoplasms (neurofibroma, dermatofibroma, smooth muscle tumors) and degenera tive cutaneous conditions (papular and follicular mucinosis) that may manifest sec ondary myxoid changes (12). However, it is unlikely that this large tumor represents an entirely and homogeneously acquired de generating process.…”

A Case of Oral Focal Mucinosis

“…OFM is a rare clinicopathological condition and is the microscopic counterpart of the cutaneous focal mucinosis. In 1966, Johnson and Helwig explained solitary, asymptomatic, white papules or nodules usually seen on the face, trunk, and extremities, naming them as cutaneous focal mucinosis (7). OFM was first mentioned by Tomich in 1974 (3).…”