Cutaneous eruptions from suramin. A clinical and histopathologic study of 60 patients

Lowitt, M. H.

doi:10.1001/archderm.131.10.1147

Cited by 7 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because other studies and our preliminary data revealed that a single dose of suramin is not toxic at 10 mg/kg, 49 we did not include sham injury groups with a variety of suramin doses. Also, because suramin has a long half-life (421 days) and accumulates in the kidney, 43,50 only a single dose was given.…”

Section: Materials and Methods Chemicals And Reagentsmentioning

confidence: 99%

Suramin promotes recovery from renal ischemia/reperfusion injury in mice

Zhuang

Lü

Daubert

et al. 2009

Kidney International

View full text Add to dashboard Cite

Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mice, in particular its effect when administered after renal injury has been established. Increasing concentrations of suramin were given 24 hours following reperfusion, a time when serum creatinine levels were at their highest level. This treatment improved renal function, as evidenced by decreased blood urea nitrogen and serum creatinine to control values and diminished histopathologic tubular damage. Suramin-treated animals had a significant reduction in apoptotic tubular cells and infiltrating leukocytes. There was also an increase of proliferating tubular cells following reperfusion compared to the number found in untreated animals. Our study shows that suramin promotes the recovery of renal function and has effective therapeutic applications when given after the occurrence of renal injury.

show abstract

Section: Materials and Methods Chemicals And Reagentsmentioning

confidence: 99%

Suramin promotes recovery from renal ischemia/reperfusion injury in mice

Zhuang

Lü

Daubert

et al. 2009

Kidney International

View full text Add to dashboard Cite

show abstract

“…The negative reaction showed on photograph is an absence of bulla formation on the surface of the lesion after injection T A B L E 2 Calculation of sensitivity, specificity, positive predictive value, and negative predictive value of the proposed skin test to differentiate lichenoid drug reaction and lichen planus The cause of the disease can be different medications ranging from "home kit" medicines to molecular biology preparations. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Several authors described cases of development of a LDE reaction after vaccination. 28,29 In our study, ACE inhibitors and NSAIDs were the drugs that caused the LDE reaction, usually with delayed onset.…”

Section: Discussionmentioning

confidence: 99%

“…The cause of the disease can be different medications ranging from “home kit” medicines to molecular biology preparations 5‐20 . Several authors described cases of development of a LDE reaction after vaccination 28,29 .…”

Section: Discussionmentioning

confidence: 99%

“…The nature of the reaction depends on the patient's response, the dose of the medication, repeated contact with the medication, and the simultaneous use of other medications. Medications involved in the development of an LDE include amplodepine, 5 captopril, enalapril, 6,7 propranalol, oxprenalol, labetolol, [8][9][10] gold salts 11 , immunoglobulin, 12note levamisole, 13 NSAIDs, 14 penicillamine, 15 imatinib mesylate, 16 streptomycin 14 simvastatin, 17 suramin, 18 rifampicin, 19 molecularly-biological [Correction added on 20 July, after first online publication: Dr. Shalaeva name has been corrected to Evgeniya V. Shalaeva. ] drugs, 20 antimalarial drugs, thiazide diuretics, furosemide, spironolactone, antituberculous drugs, 14 ketoconazole, and so forth.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The new differential diagnostic test for the lichenoid drug eruption

Sidikov

Zaslavsky

Sadykov³

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

The differential diagnosis between lichenoid drug eruption (LDE) and lichen planus (LP) is difficult due to similar clinical and histological signs but important for treatment and prognosis. The purpose of this study was to propose the new diagnosis method for differentiate LDE from LP. During 2015-2018, 20 patients with confirmed LDE, 13 patients with LP and 134 controls were examined and treated at the Lenoblcenter. All enrolled patients were underwent the injection of 0.5 mL of the 2% lidocaine solution by insulin syringe into the papule with following histological examination. The formation of a blister (bulla) at the site of injection was considered a positive test result. Among LDE, 18 of 20 patients were found positive for developing blister (bulla) and two results were questionable. In 12 of 13 LP patents, bulla on the site of injection was not identified and the result of one patient was nonspecific. All

show abstract

“…Another theory holds that chemotherapeutic-induced photo recall involves UV -induced damage to cutaneous vasculature. These vascular changes can be long lasting, explaining why recall reactions can occur months after the initial sun exposure [10]. Some speculate that similar mechanisms may underlie antibiotic-induced recall.…”

Section: Discussionmentioning

confidence: 99%

Photo recall reaction following the use of vancomycin

Jibbe

Tefft²,

Weir³

et al. 2013

Dermatology Online Journal

View full text Add to dashboard Cite

Drug-induced erythema in the distribution of prior sunburn is called photo recall. Although more commonly induced by chemotherapeutics, it has also been associated with antibiotics such as ampicillin, cephalosporin, and gentamicin. Vancomycin has not been previously reported as a causal agent. This case report describes photo recall in a fifty-three year old woman undergoing treatment with vancomycin for a MRSA infection of the spine. Her eruption followed a photo-distributed pattern on the chest, shoulders, neck and face sparing areas previously protected by her bathing suit. Of note, she reported a similar eruption following vancomycin two years prior.

show abstract

Cutaneous eruptions from suramin. A clinical and histopathologic study of 60 patients

Cited by 7 publications

References 0 publications

Suramin promotes recovery from renal ischemia/reperfusion injury in mice

Suramin promotes recovery from renal ischemia/reperfusion injury in mice

The new differential diagnostic test for the lichenoid drug eruption

Photo recall reaction following the use of vancomycin

Contact Info

Product

Resources

About