Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population

Büyüköztürk, Suna; Kekik, Çiğdem; Gökyiğit, A Z; Filik, Fadime Irsel Tezer; Karakaya, Gül; Saygı, Serap; Dursun, Adile Berna; Kırbaş, Serkan; Tüfekçi, Ahmet; Sin, Aytül; Aydoğdu, İbrahim; Sorgun, Mine Hayriye; Gelincik, Aslı; Çolakoğlu, Bahaüddin; Çelik, Gökhan; Oğuz, Fatma

doi:10.23822/eurannaci.1764-1489.23

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…Each antiepileptic was analyzed separately. For carbamazepine, there were 42 case–control studies [14–54] and 7 meta-analyses [41,55–60]. For lamotrigine, there were 30 case–control studies [16,18,20,28,36,41,44,48,51,61–74] and three meta-analyses [68,70,72].…”

Section: Resultsmentioning

confidence: 99%

“…For carbamazepine, there were 42 case–control studies [14–54] and 7 meta-analyses [41,55–60]. For lamotrigine, there were 30 case–control studies [16,18,20,28,36,41,44,48,51,61–74] and three meta-analyses [68,70,72]. As all the case–control studies for carbamazepine and lamotrigine were included in the meta-analyses, we only analyzed the results of the meta-analyses.…”

Section: Resultsmentioning

confidence: 99%

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Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens–Johnson syndrome/toxic epidermal necrolysis

Tham,

Yek,

Liu

2024

Pharmacogenetics and Genomics

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Purpose This umbrella review was conducted to summarize the association between HLA*1502 allele with antiepileptic induced Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Methods Pubmed, Scopus and EMBASE were searched for eligible reviews in May 2023. Two authors independently screened titles and abstracts and assessed full-text reviews for eligibility. The quality of meta-analyses and case–control studies was appraised with Assessing the Methodological Quality of Systematic Reviews 2 and Newcastle-Ottawa Scale, respectively. Narrative summaries of each antiepileptic drug were analyzed. Preestablished protocol was registered on the International Prospective Register of Systematic Reviews Registry(ID: CRD42023403957). Results Included studies are systematic reviews, meta-analyses and case–control studies evaluating the association of HLA-B*1502 allele with the following antiepileptics. Seven meta-analyses for carbamazepine, three meta-analyses for lamotrigine (LTG), three case–control studies for oxcarbazepine, nine case–control studies for phenytoin and four case–control studies for phenobarbitone were included. The findings of this umbrella review suggest that there is a strong association between HLA-B-1502 with SJS/TEN for carbamazepine and oxcarbazepine and a milder association for lamotrigine and phenytoin. Conclusion In summary, although HLA-B*1502 is less likely to be associated with phenytoin or lamotrigine-induced SJS/TEN compared to carbamazepine-induced SJS/TEN, it is a significant risk factor that if carefully screened, could potentially reduce the development of SJS/TEN. In view of potential morbidity and mortality, HLA-B*1502 testing may be beneficial in patients who are initiating lamotrigine/phenytoin therapy. However, further studies are required to examine the association of other alleles with the development of SJS/TEN and to explore the possibility of genome-wide association studies before initiation of treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens–Johnson syndrome/toxic epidermal necrolysis

Tham,

Yek,

Liu

2024

Pharmacogenetics and Genomics

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“…For Carbamazepine, there were 42 case-control studies(11-14)(15-52)and 7 meta analyses (39,(53)(54)(55)(56)(57)(58). For Lamotrigine, there were 30 case-control studies (13,15,17,26,34,39,42,46,49,(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72) and 3 meta-analyses (66,68,70). As all the case-control studies for Carbamazepine and Lamotrigine were included in the meta-analyses, we only analysed the results of the meta-analyses.…”

Section: Study Characteristicsmentioning

confidence: 99%

Unravelling the Genetic Link: An Umbrella Review on HLA-B∗15:02 and Anti-Epileptic Drug-induced Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis

Liu,

tham,

Yek

2023

Preprint

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Purpose This umbrella review was conducted to summarize the evidence between association between HLA*1502 allele with various antiepileptic induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Methods Pubmed, Scopus and EMBASE were searched for eligible reviews in May 2023. Study was registered in PROSPERO. Two authors independently screened titles and abstracts and assessed full-text reviews for eligibility. The quality of meta-analyses was appraised with AMSTAR-2 and the quality of case control studies were appraised with Newcastle- Ottawa Scale (NOS). Narrative summaries of each anti-epileptic drug were analysed. Pre-established protocol was registered on the International Prospective Register of Systematic Reviews database (ID: CRD42023403957). Results Included studies are meta-analyses and case control studies evaluating the association of HLA-B*1502 allele with the following antiepileptics: 7 meta-analyses for Carbamazepine (CBZ), 3 meta-analyses for Lamotrigine (LTG), 3 case-control studies for Oxcarbazepine (OXC), 9 case-control studies Phenytoin (PHT) and 4 case-control studies study for Phenobarbitone. The findings of this umbrella review suggest that there is strong association between HLA B-1502 with SJS/TEN for Carbamazepine and Oxcarbazepine and a milder association for Lamotrigine and Phenytoin. Conclusions In summary, although HLA-B*1502 is less likely to be associated with Phenytoin or Lamotrigine -induced SJS/TEN compared to Carbamazepine-induced SJS/TEN, it is a significant risk factor which if carefully screened could potentially reduce development of SJS/TEN. In view of potential morbidity and mortality, HLA-B*1502 testing may be beneficial in patients who are initiating Lamotrigine / Phenytoin therapy. However, further studies are required to examine the association of other alleles with development of SJS/TEN and to explore the possibility of genome-wide association studies prior to initiation of treatment.

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“…Genetik çalışmalar, HLA lokuslarının aşağıdaki hastalıklar ile ilişkisi için pek çok kanıt sağlamıştır (Messemaker et al, 2015;Büyüköztürk et al, 2018;Yarman et al, 2007;Oguz et al, 2004;Blackwell et al, 2009;Chen et al, 2003; 1. Otoimmün ve enflamatuar hastalıklar: Akut ön üveit, alopesi areata, astım, atopik dermatit, egzama, romatoid artrit, behçet hastalığı, çölyak hastalığı, kollajen kolit, polianjitis granülomatoz (Wegener granülomatoz), ankilozan spondilit, sistemik lupus eritematozus, vaskülit, tip 1 diyabet, crohn hastalığı, ülseratif kolit, dermatomiyozit ve graves hastalığı (Messemaker et al, 2015;Büyüköztürk et al, 2018;Yarman et al, 2007;Oguz et al, 2004) 2. Enfeksiyonlar: Önceki çalışmalarda, HLA ve HLA dışı lokuslarının çoğu, enfeksiyona karşı bağışıklık yanıtlarının genetik bileşenleri veya aşılama ve kalıcı antikor gelişimi ile yakından ilişkili bulunmuştur.…”

Section: İmmünogenetik Ve Kalıtsal Multifaktöriyel Hastalıklar Riskiunclassified

“…Araştırmacılar spesifik HLA alellerinin, insan immün yetmezlik virüsü tip 1, insan T hücresi lösemi virüsü tip 1, hepatit C virüsü ve SARS-CoV gibi viral enfeksiyonların orataya çıkışı ve bazı allelerin bu hastalıklara yatkınlık oluşturduğunu göstermişlerdir (Blackwell et al, 2009;Chen et al, 2003; 3. Olumsuz ilaç reaksiyonları: Stevens-Johnson sendromu/toksik epidermal nekroliz (karbamazepin), agranülositoz (klozapin), pankreatit (tiyopürin) ve karaciğer hasarı (terbinafin, fenofibrat, tiklopidin ve pazopanib) (Büyüköztürk et al, 2018) 4. Aşılara yanıt: Hepatit B…”

Section: İmmünogenetik Ve Kalıtsal Multifaktöriyel Hastalıklar Riskiunclassified

İmmünogenetik ve Biyoenformatik Uygulamalarının Tıp Bilişimine Entegrasyonu

Oğuz¹,

Karadeniz²

2021

Tıp Bilişimi

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T ve B hücreleri, omurgalılarda adaptif veya edinilmiş bağışıklık sisteminin bir parçasıdır. Bu hücreler, yüzeylerinde bir antijen reseptörü, antijenlerin tanınmasından sorumlu T hücresi reseptörü (TCR) veya B hücresi reseptörü/ İmmünoglobulin (Ig) eksprese eder. Büyük doku uyum kompleksi (MHC) proteinleri tüm yüksek omurgalılarda bulunur İnsanlarda bu komplekse insan lökosit antijen (HLA) sistemi adı verilmiştir. MHC sınıf I ve II molekülleri peptit reseptörleri olarak kabul edilebilir ve bu kompleks, T hücresi reseptörü tarafından tanınabilir. MHC molekülleri sadece T hücrelerine peptitler sunmakla kalmaz, aynı zamanda birkaç doğal öldürücü hücre (NK) reseptörü için de ligand olarak görev yaparlar . MHC-I'in birçok hücrede çok fazla ekspresyonu nedeniyle, NK hücreleri bu reseptörlerle etkileşimler yoluyla sağlıklı dokuya karşı sessiz kalır. Yeni tekniklerin sayesinde, diğer yaşam bilimleri gibi immünogenetik, veri açısından zengin bir dönemine girmiştir.Yeni yüksek verimlilikteki veriler, bağışıklık sisteminin karmaşık yapılarını incelememizi sağlar. Bununla birlikte, bunu doğru bir şekilde yapmak, biyoinformatistlerin ve hesaplamalı biyologların immünologlarla yakın işbirliği içinde çalıştığı disiplinler arası bir yaklaşımı gerektirir.

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Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population

Cited by 10 publications

References 13 publications

Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens–Johnson syndrome/toxic epidermal necrolysis

Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens–Johnson syndrome/toxic epidermal necrolysis

Unravelling the Genetic Link: An Umbrella Review on HLA-B∗15:02 and Anti-Epileptic Drug-induced Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis

İmmünogenetik ve Biyoenformatik Uygulamalarının Tıp Bilişimine Entegrasyonu

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