Cutaneous Drug Eruption to Infliximab: Report of 4 Cases With an Interface Dermatitis Pattern

Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review

“…76,83,84 The reported cases were treated for RA and ankylosing spondylitis. Histopathologic features revealed a diffuse lymphocytic infiltrate in the superficial dermis with a liquefactive degeneration of the basal cell layer and foci of epidermal necrosis, a pattern implying an immunemediated cytotoxic mechanism.…”

Cutaneous Adverse Events of Biological Therapy for Psoriasis: Review of the Literature

“…Several cases of erythema multiforme and lichenoid eruptions with an interface dermatitis pattern on histology [22, 23] have been observed in patients treated with infliximab for arthritis.…”

Cutaneous Adverse Reactions during Anti-Tnf Alpha Treatment for Inflammatory Bowel Diseases: The Experience of the Dermatology Clinic of Cagliari

“…Several inflammatory conditions are reported in anecdotal association to anti-TNF treatment, such as the lupus erythematosus, lichenoid dermatitis, urticarial reactions we also observed [13,[24][25][26][27][28][29][30]52]. Peculiar findings were the occurrence of a symptomatic photosensitivity, requiring active photo protection in two subject with IV to V Fitzpatrick phototype; an alopecia areata, and a hypertrichosis case, which are rarely reported controversial events [53][54][55][56][57].…”

“…More rarely, lupus erythematosus [24,25], acneiform eruption [26], sarcoidosis [27], anular granuloma [28], interstitial granulomatous dermatitis [29], lichenoid eruptions [30], erythema multiforme [31], leucocytoclasic vasculitis [32], purpura [33], dermatomyositis [34], eruptive benign lesions [35], and melanoma [36][37][38] are reported. In the present paper, we have focused on cutaneous adverse reactions to anti-TNFα agents and their proper management, comparing our data and results with those reported in the international literature.…”