Cutaneous Changes Following Local Injection of Triamcinolone

Epidural tissue reaction post interlaminar particulate steroid injection: A case series and systematic review

“…Based on this novel finding, the authors conducted a systematic review of the literature. Although histological changes post particulate corticosteroid injection have been described in dermatological literature, similar findings in the epidural space have not been previously reported 7,15–19 …”

“…Later, Schetman, Hambrick, and Wilson performed a prospective single‐case experimental design to investigate the pathogenesis of tissue atrophy following triamcinolone diacetate injections in a cohort of 25 healthy adult males (Table 3). 17 Possible correlations between tissue atrophy and variables such as the anatomical site of injection were analyzed. Superficial intradermal injections of the back developed tissue atrophy approximately 2 weeks post injection with subepidermal areas of coagulative necrosis with perivascular immune infiltrates within 24 hours.…”

“…Subsequently, Schetman et al reported on granular interfibrillar accumulations following cutaneous triamcinolone injections. 17 Balogh et al similarly noted circumscribed collections of acellular finely granular material, and Weedon et al described granular granulomatous material upon skin biopsies. 7,19 The case report by Lund et al also described regions of acellularity over areas of skin discoloration and atrophy, and Wolff presented evidence that these tissue changes are not confined to the skin, reporting similar findings within the nasal mucosa.…”

Successful treatment of corticosteroid-induced cutaneous atrophy and dyspigmentation with intralesional saline in the setting of keloids

“… 1 , 2 , 3 Cutaneous atrophy resolution, ranging from months to a few years, parallels the disappearance of crystalline deposits from the affected tissue. 1 , 2 , 3 …”

The use of intralesional corticosteroid combined with narrowband ultraviolet B in vitiligo treatment: clinical, histopathologic, and histometric evaluation

“…also reported that histopathological changes after local injection of triamcinolone occurred because of a decrease in mucopolysaccharide that was associated with loss of elastic tissue, homogenization of collagen, epidermal atrophy, and degenerative changes in the appendages. However, these changes were reversible 16 …”