Cutaneous adverse drug reaction in a dog associated with imepitoin

Royaux, Emilie; Bhatti, Sofie; Cock, H. De; Ham, Luc Van; Kitshoff, Adriaan; Vandenabeele, Sophie

doi:10.1111/vde.12289

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Hypotension may have developed without glucocorticoid administration because skin detachment resembled that in severe burn patients, who commonly develop SIRS. Indeed, an anti‐inflammatory dose of glucocorticoid was employed to manage cutaneous drug hypersensitivity to avoid the risk of SIRS in a previous study 14. However, the reported case had not developed systemic symptoms (skin lesion was limited to the lips and philtrum) as presented in our cases, so healing may have been achievable simply with removal of the offending drugs without administration of an immunosuppressive dose of glucocorticoid 17.…”

Section: Discussionmentioning

confidence: 69%

“…Different views on the efficacy of glucocorticoids for this disease have been reported, but rapid treatment with early tapering appears to have a role to play in effective immunosuppression without potential negative effects such as increased susceptibility to infection, interference with wound healing or increased mortality in humans 12 13. On the other hand, although successful use of these therapies has been seen in dogs with cutaneous drug hypersensitivity using anti‐inflammatory doses,14 little is known about the course of treatment with immunosuppressive dose for cutaneous drug hypersensitivity. Although we achieved successful outcomes in three cases with high doses for a short period, we cannot make any definitive statement regarding the efficacy of agents for the treatment of this disease based on these cases alone.…”

Section: Discussionmentioning

confidence: 99%

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Successful intensive management in dogs with postoperative cutaneous drug hypersensitivity

Sasaki¹,

Mutoh

Shiga

et al. 2018

Vet Record Case Reports

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This case report describes three cases of canine cutaneous drug hypersensitivity with systemic signs presumed to be secondary to perioperative drug administration suspected to induce either erythema multiforme (EM) or Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Tentative diagnoses on the canine EM and SJS/TEN disease spectrum were based on clinical and histological assessments. Although no general consensus has been reached regarding the diagnostic criteria and evidence-based treatment standards for this disease spectrum in veterinary medicine, along with early identification of dermatological signs and withdrawal of suspected drugs, commencement of intensive management as a patient with burn injury in a medical intensive care unit results in favourable outcomes even with generalised disease. This report highlights the importance of early identification and intensive care for the disease and the need for further investigation of the efficacy of adjunctive therapies with reported immunomodulatory agents including glucocorticoids and human immunoglobulins to establish evidence-based treatment standards.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Successful intensive management in dogs with postoperative cutaneous drug hypersensitivity

Sasaki¹,

Mutoh

Shiga

et al. 2018

Vet Record Case Reports

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“…Cutaneous drug adverse reactions have been described in association with the use of various drugs, including meloxicam [23], imepitoin [24] and phenobarbital. Similar changes to drug adverse reactions can be also seen in chemical (photosensitivity) or contact dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Traumatic Blepharitis Including Cutanous Changes with a Clinical Appearance of Immune-Mediated Disease

Kecova

Natalija

Lazic³

et al. 2021

Acta Veterinaria

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A four-year-old intact male Labrador retriever was presented with acute onset of ulcerative lesions around both eyes, on the mucocutaneous junctions around the muzzle and nares, and on the lateral aspects of paw pads. All lesions were symmetrical and well demarcated. The rest of ocular and systemic examination was unremarkable. The onset of lesions was acute and coincided with an episode of intense hunting in switchgrass. Similar lesions were present in another dog used in the same hunting trip. The clinical presentation was suggestive of a possible immune-mediated skin disease. However, the patient responded to systemic antibiotic treatment with full recovery without recurrence upon cessation of therapy. Traumatic origin should be included into differential diagnosis of mucocutaneous ulcerative lesions presenting as a possible immune-mediated skin disease.

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“…In humans, clinical signs vary from skin changes to cardiovascular changes or bronchospasm (5). In dogs, ADRs have been reported to present with skin changes and thrombocytopenia (6)(7)(8). Cutaneous ADR is an adverse drug reaction that appears on the skin first (2), and the lesions imitate any other skin disease (2,9,10).…”

Section: Introductionmentioning

confidence: 99%

Case report: Uncommon immune-mediated skin disease involving systemic disorders in dogs

Kim

2022

Front. Vet. Sci.

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Case 1, a 6-year-old, spayed female Pug, presented with severe systemic urticaria, edema, and erythema. The dog had received a famotidine injection as a treatment for repeated vomiting in another hospital. On physical examination, hyperthermia was observed. Moderate pancytopenia, hypoalbuminemia, and increased CRP and D-dimer were also observed in blood tests. Hyposthenuric proteinuria, pulmonary interstitial infiltration, and hepatomegaly were found in other tests. In the histology of the skin, dermal edema and infiltration of inflammatory cells were observed. Therefore, she was diagnosed with acute systemic hypersensitivity. Case 2, a 13-month-old, neutered male Pembroke welsh corgi, presented with severe and patchy systemic ulcerative skin lesions. The dog had a history of soft feces and pain around the anus 2 days before. Thrombocytopenia, and increased CRP and D-dimer were observed in blood tests. In histology, epidermal necrolysis, separation of the epidermis and dermis, and infiltration of inflammatory cells were observed. Therefore, he was diagnosed with an immune-mediated disease with necrolysis dermatitis. Case 3, a 12-year-old, spayed female Pomeranian, presented with severe systemic alopecia, pustule, and crust on the skin. The dog had received an infection treatment from a local hospital. Severe regenerative anemia (hematocrit 15.3%, negative saline agglutination test, negative slide agglutination test, negative Coomb's test, prominent spherocytes) elevated liver enzymes, and increased CRP and D-dimer were observed in blood tests. On histopathology of the skin, pustules, acantholytic cells, and inflammatory cells were observed in the keratin layer of the epithelium. Therefore, she was diagnosed with Pemphigus foliaceus concurrent with immune-mediated hemolytic anemia. The 3 cases were diagnosed with fatal immune-mediated skin disease concurrently with hematological and systemic abnormalities. All the cases were treated with immune-suppressive drugs, prednisolone, and cyclosporine. In cases 2 and 3, the dogs also received human intravenous immunoglobulin as an immune modulator. The treatment was successful with significant improvements in all the 3 cases.

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Cutaneous adverse drug reaction in a dog associated with imepitoin

Abstract: Imepitoin may result in cutaneous adverse drug reactions in dogs.

Cited by 5 publications

References 16 publications

Successful intensive management in dogs with postoperative cutaneous drug hypersensitivity

Successful intensive management in dogs with postoperative cutaneous drug hypersensitivity

Traumatic Blepharitis Including Cutanous Changes with a Clinical Appearance of Immune-Mediated Disease

Case report: Uncommon immune-mediated skin disease involving systemic disorders in dogs

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