Cutaneous γδ T-Cell Lymphomas—How and Why Should They Be Recognized?

Kadin, Marshall E.

doi:10.1001/archderm.136.8.1052

Cited by 18 publications

(18 citation statements)

References 33 publications

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“…In recent years, the spectrum of CTCLs has been widened by more precise observations and the recognition of new diagnostic categories such as blastic NK-cell lymphoma, 10,11,15,19,21,30,33,67,71 nasal-type extranodal NK/T-cell lymphoma, 16,17,18,20,44,50,62 primary cutaneous aggressive CD8+ epidermotropic T-cell lymphoma, 1,9,32 cutaneous ␥/␦ T-cell lymphoma, 8,29,47,49,64,85,86 and SPTCL. 12,35,43,90,92 These lymphomas originate from cytotoxic T lymphocytes, NK cells, and myeloid-NK cell precursors, and can either arise within the skin as primary cutaneous lymphomas or spread to the skin as secondary manifestations of extracutaneous lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Massone

Chott²,

Metze³

et al. 2004

American Journal of Surgical Pathology

214

180

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A new group of subcutaneous, natural killer (NK), NK/T-cell, and other cytotoxic T-cell lymphomas of the skin has been recently described, and some have been included as distinct clinicopathologic entities in the classification of hematologic malignancies recently proposed by the World Health Organization. In the European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas, they would be classified either as CD30- large T-cell lymphoma, small/medium pleomorphic T-cell lymphoma, or subcutaneous T-cell lymphoma. Precise clinicopathologic and prognostic features of all of them have not yet been well characterized. We studied retrospectively 81 biopsies from 50 patients with subcutaneous, blastic natural killer (NK), NK/T-cell, or other non-mycosis fungoides cytotoxic T-cell lymphomas of the skin. Clinical, morphologic, phenotypical, and genetic features and data on Epstein-Barr virus association allowed us to classify our cases according to the following 7 categories: a) subcutaneous "panniculitis-like" T-cell lymphoma (SPTCL): 10 cases (estimated 5-year survival: 80%); b) blastic NK-cell lymphoma: 12 cases (estimated 5-year survival: 0%); c) nasal-type extranodal NK/T-cell lymphoma: 5 patients (estimated 5-year survival: 0%); d) epidermotropic CD8+ T-cell lymphoma: 5 cases (estimated 5-year survival: 0%); e) cutaneous gamma/delta T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); f) cutaneous alpha/beta pleomorphic T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); and g) cutaneous medium/large pleomorphic T-cell lymphoma, not otherwise specified: 2 cases. Our study shows that these cutaneous lymphomas can be classified according to precise diagnostic categories. With the exception of SPTCL, analysis of follow-up data from our patients showed that these groups of lymphomas are characterized by an aggressive course, regardless of the diagnostic category.

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Section: Discussionmentioning

confidence: 99%

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Massone

Chott²,

Metze³

et al. 2004

American Journal of Surgical Pathology

214

180

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“…130 Furthermore, the rare type of cutaneous TCRgd þ T-cell lymphomas express Vd2 and therefore appear to represent a clonal expansion of TCRgd þ T cells that normally reside in the skin. 131 Other clonal TCRgd proliferations include CD3 þ TCRgd þ LGL proliferations that comprise about 5% of all CD3 þ LGL and often show Vd1-Jd1 rearrangements (Table 19). 132 The development of monoclonal antibodies towards FR regions of TCRgd and more recently to specific Vd gene segments has helped identify TCRgd þ T-cell populations by flow cytometric analysis, 15 but PCR clonality studies are still required to identify whether these populations represent clonal or polyclonal expansions.…”

Section: Introductionmentioning

confidence: 99%

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936

et al. 2003

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“…46 Cutaneous g/d lymphomas, which may present with angiocentric or subcutaneous infiltrates and ulcers, exhibit a poor prognosis, by definition have to express the g/d chain of the TCR (TCR-d + ), and lack the expression of b-F1 (a/b chain of TCR). 47,48 In our series of LyP type E, atypical lymphoid cells in all cases stained for this marker expressed b-F1 and were negative for TCR-d thereby excluding cutaneous g/d lymphoma. Other cytotoxic lymphomas such as primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma is a highly aggressive lymphoma with CD8 + epidermotropic infiltrates and numerous necrotic keratinocytes but is consistently CD30 negative.…”

Section: Discussionmentioning

confidence: 68%

Angioinvasive Lymphomatoid Papulosis

Kempf

Kazakov

Schärer

et al. 2013

American Journal of Surgical Pathology

182

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Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders. Clinically, LyP is characterized by a variable number of self-healing papulo-nodular lesions, with the typical waxing and waning course. Histologically, 4 types (A, B, C, and D) have been delineated. Angioinvasive growth and large ulcers are rare findings in LyP and simulate aggressive lymphoma. We retrospectively analyzed the clinicopathologic and molecular features of angioinvasive LyP in a series of 16 patients. This new form of LyP is characterized by oligolesional papules that rapidly ulcerate and evolve into large necrotic eschar-like lesions with a diameter of 1 to 4 cm and an angiocentric and angiodestructive infiltrate of small-sized to medium-sized atypical lymphocytes expressing CD30 and frequently CD8. As in other forms of LyP, the lesions underwent spontaneous regression after a few weeks. Recurrences were common, but the prognosis was excellent with no extracutaneous spread or disease-related deaths. Complete remission occurred in 9 of 16 patients (56%). This LyP variant should be distinguished from aggressive forms of angiocentric and angiodestructive and cytotoxic T-cell lymphomas. We propose the term LyP type E for this clinically and histologically unusual variant.

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Cutaneous γδ T-Cell Lymphomas—How and Why Should They Be Recognized?

Cited by 18 publications

References 33 publications

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936

Angioinvasive Lymphomatoid Papulosis

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