Cut-off points of knee extension strength allometrically adjusted to identify sarcopenia risk in older adults: A cross-sectional study

Abdalla, Pedro Pugliesi; Carvalho, Anderson dos Santos; Santos, André Pereira dos; Venturini, Ana Cláudia Rossini; Alves, Thiago Cândido; Mota, Jorge; Oliveira, Alcivandro de Sousa; Ramos, Nilo César; Marini, José Augusto Gonçalves; Machado, Dalmo Roberto Lopes

doi:10.1016/j.archger.2020.104100

Cited by 24 publications

(62 citation statements)

References 58 publications

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“…Measurements of muscle strength included handgrip strength and knee flexion/extension techniques. The cutoff points for knee extension strength for men and women were respectively, 56.1 and 38.1 kg for one-repetition maximum as reported by Abdalla et al [ 27 ]. This is equivalent to 550.15 and 373.63 Newtons for men and women.…”

Section: Methodsmentioning

confidence: 93%

Association between protoporphyrin IX and sarcopenia: a cross sectional study

2021

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Background According to the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia primarily focused on low muscle strength with the detection of low muscle quality and quantity as confirming index. Many studies had identified mitochondrial dysfunction as one of the multifactorial etiologies of sarcopenia. Yet, no study had investigated the role of biosynthetic pathway intermediate, which was found in mitochondria, in the development of sarcopenia. This study aimed to examine the association between protoporphyrin IX (PPIX) and components of sarcopenia. Method The present study enrolled 1172 participants without anemia between 1999 to 2002 from the National Health and Nutrition Examination Survey (NHANES) database. We employed the multivariable-logistic regression model to examine the relationship between PPIX and sarcopenia. Covariate adjustments were designated to each of the three models for further analysis of the relationship. Results In the unadjusted model, PPIX was significantly associated with sarcopenia (OR = 3.910, 95% CI = 2.375, 6.439, P value < 0.001). The significance persisted after covariate adjustments as observed in the fully adjusted model (OR = 2.537, 95% CI = 1.419, 4.537, P value = 0.002). Conclusions The findings of this study suggested statistically significant association between PPIX and sarcopenia. Our study disclosed the potential of PPIX as a valuable indicator of sarcopenia.

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Section: Methodsmentioning

confidence: 93%

Association between protoporphyrin IX and sarcopenia: a cross sectional study

2021

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“…Finally, there is a growing need for data sharing and creation of an international registry to assist in the development of standardized guidelines to improve the diagnosis and treatment of POI and its associated musculoskeletal complications. 132 Hand grip Jamar-Smedley dynamometer is recommended to assess hand-grip strength 147 Moderate correlation with strength in other body compartments and serves as a reliable surrogate 52 Not sensitive to strength improvements in older adults performing strength training No cut-off values defined for women <45 years Knee extension May better represent lower-limb strength and be more sensitive to strength improvements than hand-grip strength Few standardized approaches require gym equipment and are time-consuming 148 Chair-rise test Suggested to provide a measure of lower-limb strength and endurance 52,149 ; however, it may be more closely related to physical performance than strength 150 No cut-off values defined for women <45 years…”

Section: Discussionmentioning

confidence: 99%

“…May better represent lower-limb strength and be more sensitive to strength improvements than hand-grip strength Few standardized approaches require gym equipment and are time-consuming 148 Chair-rise test Suggested to provide a measure of lower-limb strength and endurance 52,149 ; however, it may be more closely related to physical performance than strength 150 No cut-off values defined for women <45 years…”

Section: Knee Extensionmentioning

confidence: 99%

Musculoskeletal Health in Premature Ovarian Insufficiency. Part One: Muscle

et al. 2020

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Accelerated bone loss and muscle decline coexist in women with premature ovarian insufficiency (POI), but there are significant gaps in our understanding of musculoskeletal health in POI. This article is the first of a two-part review which describes estrogen signaling in muscle and its role in musculoskeletal health and disease. Current evidence regarding the utility of available diagnostic tests and therapeutic options is also discussed. A literature review from January 2000 to March 2020 was conducted to identify relevant studies. Women with POI experience significant deterioration in musculoskeletal health due to the loss of protective effects of estrogen. In addition to bone loss, muscle decay and dysfunction is now increasingly recognized. Nevertheless, there is a paucity of validated tools to assess muscle parameters. There is a growing need to acknowledge bone–muscle codependence to design new therapies which target both muscle and bone, resulting in improved physical performance and reduced morbidity and mortality. More high-quality research and international collaborations are needed to address the deficiencies in our understanding and management of musculoskeletal health in women with POI.

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“…When untreated, sarcopenia exposes older adults to functional impairment, mobility disorders, increased risk of falls, loss of functional independence, physical frailty, increases in hospitalization, decreased quality of life, and increased risk of premature death (5). Therefore, the early identification of the disease considerably reduces the economic impact on health systems and on the personal and social burdens of care for older adults (6). For the diagnostic confirmation of sarcopenia two conditions are required: reduced muscle strength and decreased SMM (2).…”

Section: Introductionmentioning

confidence: 99%