CuS as a gatekeeper of mesoporous upconversion nanoparticles-based drug controlled release system for tumor-targeted multimodal imaging and synergetic chemo-thermotherapy

Su, Xiangjie; Zhao, Feifei; Wang, Yuhui; Yan, Xiaosa; Jia, Shaona; Du, Bin

doi:10.1016/j.nano.2017.03.008

Cited by 31 publications

(21 citation statements)

References 44 publications

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“…Recently, Su et al has developed a tumour-targeted multifunctional mesoporous upconversion nanoparticle-based theragnostic system with the potential for multimodal imaging 132. Core-shell mesoporous upconversion nanoparticles with superior upconversion luminescence emission property was integrated with CuS as a gatekeeping agent for preventing premature drug release and facilitating other therapeutic modalities.…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

Theragnostic potentials of core/shell mesoporous silica nanostructures

Girija

Balasubramanian

2019

Nanotheranostics

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Theragnostics is considered as an emerging treatment strategy that integrates therapeutics and diagnostics thus allowing delivery of therapeutics and simultaneous monitoring of the progression of treatment. Among the different types of inorganic nanomaterials that are being used for nanomedicine, core shell mesoporous silica nanoparticles have emerged as promising multifunctional nanoplatform for theragnostic application. Research in the design of core/shell mesoporous silica nanoparticles is steadily diversifying owing to the various interesting properties of these nanomaterials that are advantageous for advanced biomedical applications. Core/shell mesoporous silica nanoparticles, have garnered substantial attention in recent years because of their exceptional properties including large surface area, low density, ease of functionalization, high loading capacity of drugs, control of the morphology, particle size, tunable hollow interior space and mesoporous shell and possibility of incorporating multifunctional interior core material. In the past decade researcher's demonstrated tremendous development in design of functionalized core/shell mesoporous silica nanoparticles with different inorganic functional nanomaterial incorporated into mesoporous nanosystem for simultaneous therapeutic and diagnostic (theragnostic) applications in cancer. In this review, we recapitulate the progress in commonly used synthetic strategies and theragnostic applications of core/shell mesoporous silica nanoparticles with special emphasis on therapeutic and diagnostic modalities. Finally, we discuss the challenges and some perspectives on the future research and development of theragnostic core/shell mesoporous silica nanoparticles.

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Section: Diagnostic Applicationsmentioning

confidence: 99%

Theragnostic potentials of core/shell mesoporous silica nanostructures

Girija

Balasubramanian

2019

Nanotheranostics

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“…The Lys-CuS NPs were prepared according to the previous study. 32 In 150 mL of DI water, 0.12 mM of L-cysteine was dissolved. CuCl 2 solution (50 mL, 25 mM) was then added to the solution under vigorous stirring.…”

Section: Synthesis Of Lys-cus Npsmentioning

confidence: 99%

“…31 A recent study by Su et al reported CuS as a gatekeeper to cap the mesoporous upconversion NPs, which fabricated a multifunctional mesoporous upconversion NPbased drug controlled-release system for upconversion luminescence emission/magnetic resonance imaging/photoacoustic tomography-guided synergetic chemo-thermotherapy. 32 However, to the best of our knowledge, there is no report on gating of the CuS with PMO NPs for tumor treatment.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy

Cheng¹,

Li²,

Lin³

et al. 2018

IJN

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IntroductionFor an ideal drug delivery system, the outstanding drug-loading capacity and specific control of the release of therapeutics at the desired lesions are crucial. In this work, we developed a triple-responsive nanoplatform based on copper sulfide (CuS)-capped yolk−shell-structured periodic mesoporous organosilica nanoparticles (YSPMOs) for synergetic chemo-photothermal therapy.MethodsHerein, the YSPMOs were employed as a drug carrier, which exhibited a high doxorubicin (DOX) loading capacity of 386 mg/g. In this controlled-release drug delivery system, CuS serves as a gatekeeper to modify YSPMOs with reduction-cleavable disulfide bond (YSPMOs@CuS). CuS could not only avoid premature leakage in the delivery process, but also endowed the excellent photothermal therapy (PTT) ability.ResultsUpon entering into cancer cells, the CuS gatekeeper was opened with the breaking of disulfide bonds and the DOX release from YSPMOs(DOX)@CuS in response to the intracellular acidic environment and external laser irradiation. Such a precise control over drug release, combined with the photothermal effect of CuS nanoparticles, is possessed by synergistic chemo-photothermal therapy for cancer treatment. Both in vitro and in vivo experimental data indicated that the synergistic effect of YSPMOs(DOX)@CuS showed efficient antitumor effect. In addition, low systemic toxicity was observed in the pathologic examinations of liver, spleen, lungs, and kidneys.ConclusionThis versatile nanoplatform combination of PTT, chemotherapeutics, and gating components shows general potential for designing multifunctional drug delivery systems.

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“…5 Generally, the integration of photothermal therapy with stimuli-responsive drug delivery system requires the rational engineering of nanocarriers to realize multiple purposes. Although some photothermal agents, such as gold nanorods, 6 CuS-based nanomaterials 7 and organic conjugated polymers 8,9 have been applied as nanocarriers for simultaneously photothermal therapy and chemotherapeutic drug delivery, these formulations encounter some undesirable shortcomings, including the low drug-loading capacity, the premature drug leakage before reaching the targeted area and the long-term risk due to the poor biodegradability of those materials. 10 Therefore, it urgent to develop novel nanocarrier equipped with high drug loading, favorable biocompatibility and multiple theranostic functions.…”

Section: Introductionmentioning

confidence: 99%

<p>Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy</p>

Guo

Xia

Feng

et al. 2020

IJN

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Background: Metal-organic frameworks (MOFs) have attracted intensive research interest in the biomedical field because of their unique properties. However, in order to realize the high loading capacity and therapeutic efficacy, it is still urgent to develop a multifunctional MOFs-based nanoplatform. Materials and Methods: Herein, a pH/near-infrared (NIR) dual-responsive drug delivery system based on zeolitic imidazolate framework-8 (ZIF-8) is constructed for synergistic chemo-photothermal therapy and dual-modal magnetic resonance (MR)/photoacoustic (PA) imaging. The doxorubicin hydrochloride (DOX) is embedded into ZIF-8 through one-pot method, and the resultant ZIF-8/DOX is then successively modified with polydopamine, Mn ions and poly(ethylene glycol). The obtained ZIF-8/DMPP is systematically characterized, and both its in vitro and in vivo biological effects are evaluated in detail. Results: The ZIF-8/DMPP possesses a high drug-loading content of 18.9% and displays appropriate size and morphology. The pH-dependent degradation and drug release behavior of prepared ZIF-8/DMPP are confirmed. Importantly, the results demonstrate that the photothermal effect of ZIF-8/DMPP under NIR laser irradiation can significantly accelerate its drug releasing rate, further improving the intracellular drug concentrations. Thereafter, the augmented chemotherapeutic efficiency by photothermal effect against cancer cells is verified both in vitro and in vivo. Besides, the favorable MR and PA imaging capacity of ZIF-8/ DMPP is also evidenced on the tumor model. Conclusion: Taken together, the surface engineering of ZIF-8-based nanocarrier in this work offers a promising strategy for the multifunctional MOFs-based drug delivery system.

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CuS as a gatekeeper of mesoporous upconversion nanoparticles-based drug controlled release system for tumor-targeted multimodal imaging and synergetic chemo-thermotherapy

Cited by 31 publications

References 44 publications

Theragnostic potentials of core/shell mesoporous silica nanostructures

Theragnostic potentials of core/shell mesoporous silica nanostructures

Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy

<p>Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy</p>

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