Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology

Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis

“…These data support previous reports showing a reduced expression of iNOS in airway epithelial cells from patients with CF,17 18 or a reduced exhaled NO due to combination of oxygen radicals released from neutrophils with NO to form peroxynitrite 29. It also shows that exhaled CO is a better marker of oxidative stress in cystic fibrosis.…”

Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis

“…These data support previous reports showing a reduced expression of iNOS in airway epithelial cells from patients with CF,17 18 or a reduced exhaled NO due to combination of oxygen radicals released from neutrophils with NO to form peroxynitrite 29. It also shows that exhaled CO is a better marker of oxidative stress in cystic fibrosis.…”

The rationale for early intervention in cystic fibrosis: Presented at the International Cystic Fibrosis Congress Roche/Genentech satellite symposium, June 18, 1996, Jerusalem, Israel

“…Michael Konstan and Melvin Berger, with special emphasis on the neutrophils and neutrophil products. 12 In addition, through bronchoalveolar lavage analysis, this report provides a fascinating glimpse at the degree of inflammation and infection in a CF infant with marked respiratory symptoms, while also underscoring the complexity of the cytokine network in the CF airway.…”

Exhaled breath condensate MMP‐9 levels in children with bronchiectasis

“…Airway inflammation plays a critical role in the progression of CF lung diseases and the eventual destruction of airway and lung parenchyma. 30,31 Neutrophilic inflammation within the airway lumen in CF is central to the pathophysiology of the disease. Neutrophils release several proteases which degrade the extracellular matrix of airways and lung parenchyma.…”

Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis

“…These data support previous reports showing a reduced expression of iNOS in airway epithelial cells from patients with CF,17 18 or a reduced exhaled NO due to combination of oxygen radicals released from neutrophils with NO to form peroxynitrite 29. It also shows that exhaled CO is a better marker of oxidative stress in cystic fibrosis.…”

The rationale for early intervention in cystic fibrosis: Presented at the International Cystic Fibrosis Congress Roche/Genentech satellite symposium, June 18, 1996, Jerusalem, Israel

“…Michael Konstan and Melvin Berger, with special emphasis on the neutrophils and neutrophil products. 12 In addition, through bronchoalveolar lavage analysis, this report provides a fascinating glimpse at the degree of inflammation and infection in a CF infant with marked respiratory symptoms, while also underscoring the complexity of the cytokine network in the CF airway.…”

Exhaled breath condensate MMP‐9 levels in children with bronchiectasis

“…Airway inflammation plays a critical role in the progression of CF lung diseases and the eventual destruction of airway and lung parenchyma. 30,31 Neutrophilic inflammation within the airway lumen in CF is central to the pathophysiology of the disease. Neutrophils release several proteases which degrade the extracellular matrix of airways and lung parenchyma.…”

Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis

“…These data support previous reports showing a reduced expression of iNOS in airway epithelial cells from patients with CF,17 18 or a reduced exhaled NO due to combination of oxygen radicals released from neutrophils with NO to form peroxynitrite 29. It also shows that exhaled CO is a better marker of oxidative stress in cystic fibrosis.…”

The rationale for early intervention in cystic fibrosis: Presented at the International Cystic Fibrosis Congress Roche/Genentech satellite symposium, June 18, 1996, Jerusalem, Israel

“…Michael Konstan and Melvin Berger, with special emphasis on the neutrophils and neutrophil products. 12 In addition, through bronchoalveolar lavage analysis, this report provides a fascinating glimpse at the degree of inflammation and infection in a CF infant with marked respiratory symptoms, while also underscoring the complexity of the cytokine network in the CF airway.…”

Exhaled breath condensate MMP‐9 levels in children with bronchiectasis

“…Airway inflammation plays a critical role in the progression of CF lung diseases and the eventual destruction of airway and lung parenchyma. 30,31 Neutrophilic inflammation within the airway lumen in CF is central to the pathophysiology of the disease. Neutrophils release several proteases which degrade the extracellular matrix of airways and lung parenchyma.…”