Current understanding of the equine metabolic syndrome phenotype

Geor, Raymond J.; McCue, Molly E.; Schultz, Nichol

doi:10.1016/j.jevs.2013.08.010

Cited by 11 publications

(15 citation statements)

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“…Regional adiposity, obesity, hyperinsulinemia, insulin resistance (IR) and laminitis or susceptibility to laminitis are the major characteristics of equine metabolic syndrome (EMS) . It is worth noting that recent data have indicated that obesity should not be used as a diagnostic criterion EMS is a complex disorder involving alternation in metabolism and chronic systemic inflammation . However, due to its complexity, understanding EMS pathophysiology is still elusive.…”

Section: Introductionmentioning

confidence: 99%

5‐Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy

Kornicka

Szłapka-Kosarzewska

Śmieszek

et al. 2018

J Cellular Molecular Medi

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Obesity and endocrine disorders have become prevalent issues in the field of both human and veterinary medicine. Equine metabolic syndrome is a complex disorder involving alternation in metabolism and chronic systemic inflammation. It has been shown that unfavourable microenvironment of inflamed adipose tissue negatively affects adipose stem cell population (ASC) residing within, markedly limiting their therapeutic potential. ASCsEMS are characterized by increased senescence apoptosis, excessive accumulation of reactive oxygen species (ROS), mitochondria deterioration and “autophagic flux.” The aim of the present study was to evaluate whether treatment of ASCsEMS with a combination of 5‐azacytydine (AZA) and resveratrol (RES) would reverse aged phenotype of these cells. For this reason, we performed the following analyzes: molecular biology (RT‐PCR), microscopic (immunofluorescence, TEM) and flow cytometry (JC‐1, ROS, Ki67). We evaluated the mitochondrial status, dynamics and clearance as well as autophagic pathways. Furthermore, we investigated epigenetic alternations in treated cells by measuring the expression of TET genes and analysis of DNA methylation status. We have demonstrated that AZA/RES treatment of ASCsEMS is able to rejuvenate these cells by modulating mitochondrial dynamics, in particular by promoting mitochondrial fusion over fission. After AZA/RES treatment, ASCsEMS were characterized by increased proliferation rate, decreased apoptosis and senescence and lower ROS accumulation. Our findings offer a novel approach and potential targets for the beneficial effects of AZA/RES in ameliorating stem cell dysfunctions.

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Section: Introductionmentioning

confidence: 99%

5‐Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy

Kornicka

Szłapka-Kosarzewska

Śmieszek

et al. 2018

J Cellular Molecular Medi

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“…A current focus in human asthma research is the identification and characterisation of specific asthma phenotypes and treatment protocols that are personalised to the patient's specific asthma phenotype, rather than relying on the customary ‘one size fits all’ approach. An obvious parallel in equine laminitis is the horse or pony with a body condition score >6 on a scale of 1 (emaciated) to 9 (obese), sometimes referred to as the equine metabolic syndrome phenotype . Another is the horse with persistent, unilateral, nonweightbearing lameness, because these horses are at risk for contralateral or supporting limb laminitis.…”

Section: Specific Phenotypesmentioning

confidence: 99%

“…With the obesity phenotype in particular, breed appears to play an important role, although there is also a strong influence of management, particularly of diet and exercise. A number of different breeds are considered more susceptible to obesity and/or EL, including various pony breeds, Morgan Horses, Tennessee Walking Horses, American Saddlebreds, Arabians, Paso Finos, Icelandics and Andalusians . The influence of management is illustrated by a recent study of hyperinsulinaemia in ponies: in a diverse group of 188 ponies (Australian, Welsh, Connemara, Shetland) from 22 different farms, only 27% of ponies were hyperinsulinaemic on fasting blood test .…”

Section: Specific Phenotypesmentioning

confidence: 99%

Science‐in‐brief: Equine laminitis research: Milestones and goals

Orsini

2014

Equine Veterinary Journal

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“…Recentemente, os critérios diagnósticos da SME foram revistos, após terem sido considerados imprecisos em um estudo retrospectivo, o qual demonstra que o fenótipo da SME não se restringe ao conjunto de animais com claudicação inespecífica ou laminite clínica, à obesidade e à resistência à insulina (McCue et al, 2015), não sendo fator decisivo à ocorrência dos três sintomas clássicos em conjunto, mas a uma gama de alterações que demonstram disfunção metabólica, semelhante ao observado na síndrome metabólica humana (Obesity, 2012). Observações clínicas indicam que nem todos os animais que apresentam disfunção no metabolismo da insulina relacionada à SME apresentam laminite clínica (Geor et al, 2013).…”

Section: Introductionunclassified

Lipidograma e sensibilidade à insulina em éguas Mangalarga Marchador

Mello

Botteon

Hess

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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RESUMO A dislipidemia é um achado comum, porém não determinante, na síndrome metabólica equina (SME). O objetivo do presente trabalho foi caracterizar a dislipidemia em animais obesos com risco de SME. Para isso, 18 éguas foram alocadas em grupos, de acordo com escore corporal (EC) de 1 a 9: no grupo ideal, animais com EC de 4,5 a 5,5 (n= 6), no grupo sobrepeso, com EC de 6 a 7 (n= 6) e no grupo obeso, animais com EC de 7,5 a 9 (n= 6). Coletaram-se amostras de sangue em jejum de concentrado para determinação de triglicerídeos, colesterol total, glicemia e concentração de insulina. Valores preditivos de sensibilidade à insulina (RISQI) e de secreção β-pancreática (MIRG) foram calculados. O grupo obeso apresentou níveis maiores em relação aos outros grupos de triglicerídeos (P=0,001) e acima do ideal em concentrações de colesterol (P=0,012). Não foi observada diferença nas concentrações plasmáticas de glicose (P=0,53), de insulina (P=0,10) ou de RISQI (P=0,46). Houve diferença entre os grupos nos valores de MIRG (P=0,048), tendo o grupo obeso obtido resultados maiores quando comparado com o grupo ideal. O aumento do EC foi associado ao aumento das concentrações plasmáticas de colesterol e triglicerídeos, o que caracteriza um estado de dislipidemia e de elevação da secreção das células β-pancreáticas.

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Current understanding of the equine metabolic syndrome phenotype

Cited by 11 publications

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5‐Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy

5‐Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy

Science‐in‐brief: Equine laminitis research: Milestones and goals

Lipidograma e sensibilidade à insulina em éguas Mangalarga Marchador

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