Biochemical Pharmacology volume 80, issue 5, P724-730 2010 DOI: 10.1016/j.bcp.2010.04.031 View full text
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Fang Chen, Wenge Wang, Wafik S. El-Deiry

Abstract: Tumor suppressor p53 is a transcription factor that guards the genome stability and normal cell growth. Stresses like DNA damage, oncogenic assault will turn on p53 function which leads to cell cycle arrest for DNA repair, senescence for permanent growth arrest or apoptosis for programmed cell death. At the late stage of cancer progression, p53 is hijacked in all forms of tumors either trapped in the negative regulator such as MDM2/viral proteins or directly mutated/deleted. Re-introduction of a functional p53…

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