Current Practices in the Management of Ocular Toxoplasmosis

Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats

“…Pharmacokinetic data from the present study documented levels of drug in serum and a disposition of clindamycin comparable to those reported previously in more detailed studies of orally administered clindamycin in healthy cats (5,6). The effective dosage of clindamycin for the treatment of toxoplasmosis is not known, and the dosages used in the present study were derived from clinical recommendations for cats (8,37) and humans with toxoplasmosis (9,17,32,39,49) and pharmacokinetic studies with cats (5,6). Clindamycin has been shown to reduce mortality in a model of chronic toxoplasmic pneumonia in mice when it was used prophylactically, but it appears to be less effective when it is used to treat clinically apparent reactivation (19).…”

Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats

“…Pharmacokinetic data from the present study documented levels of drug in serum and a disposition of clindamycin comparable to those reported previously in more detailed studies of orally administered clindamycin in healthy cats (5,6). The effective dosage of clindamycin for the treatment of toxoplasmosis is not known, and the dosages used in the present study were derived from clinical recommendations for cats (8,37) and humans with toxoplasmosis (9,17,32,39,49) and pharmacokinetic studies with cats (5,6). Clindamycin has been shown to reduce mortality in a model of chronic toxoplasmic pneumonia in mice when it was used prophylactically, but it appears to be less effective when it is used to treat clinically apparent reactivation (19).…”

Right Active Retinitis and Left Focal Retinochoroidal Scar in a Girl with Congenital Toxoplasmosis

“…Several practices in the management of ocular toxoplas mosis have been reported [5,6]. The whitish lesion in the right fundus in our patient was located in the peripapillary region.…”

Ocular parasitosis caused by protozoan infection during travel: Focus on prevention and treatment

“…First-line therapy of chorioretinitis in toxoplasmosis includes the use of pyrimethamine with sulfadiazine and folinic acid to prevent bone marrow toxicity. [ 78 ]…”

Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats

“…Pharmacokinetic data from the present study documented levels of drug in serum and a disposition of clindamycin comparable to those reported previously in more detailed studies of orally administered clindamycin in healthy cats (5,6). The effective dosage of clindamycin for the treatment of toxoplasmosis is not known, and the dosages used in the present study were derived from clinical recommendations for cats (8,37) and humans with toxoplasmosis (9,17,32,39,49) and pharmacokinetic studies with cats (5,6). Clindamycin has been shown to reduce mortality in a model of chronic toxoplasmic pneumonia in mice when it was used prophylactically, but it appears to be less effective when it is used to treat clinically apparent reactivation (19).…”

Right Active Retinitis and Left Focal Retinochoroidal Scar in a Girl with Congenital Toxoplasmosis

“…Several practices in the management of ocular toxoplas mosis have been reported [5,6]. The whitish lesion in the right fundus in our patient was located in the peripapillary region.…”

Ocular parasitosis caused by protozoan infection during travel: Focus on prevention and treatment

“…First-line therapy of chorioretinitis in toxoplasmosis includes the use of pyrimethamine with sulfadiazine and folinic acid to prevent bone marrow toxicity. [ 78 ]…”

Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats

“…Pharmacokinetic data from the present study documented levels of drug in serum and a disposition of clindamycin comparable to those reported previously in more detailed studies of orally administered clindamycin in healthy cats (5,6). The effective dosage of clindamycin for the treatment of toxoplasmosis is not known, and the dosages used in the present study were derived from clinical recommendations for cats (8,37) and humans with toxoplasmosis (9,17,32,39,49) and pharmacokinetic studies with cats (5,6). Clindamycin has been shown to reduce mortality in a model of chronic toxoplasmic pneumonia in mice when it was used prophylactically, but it appears to be less effective when it is used to treat clinically apparent reactivation (19).…”

Right Active Retinitis and Left Focal Retinochoroidal Scar in a Girl with Congenital Toxoplasmosis

“…Several practices in the management of ocular toxoplas mosis have been reported [5,6]. The whitish lesion in the right fundus in our patient was located in the peripapillary region.…”

Ocular parasitosis caused by protozoan infection during travel: Focus on prevention and treatment

“…First-line therapy of chorioretinitis in toxoplasmosis includes the use of pyrimethamine with sulfadiazine and folinic acid to prevent bone marrow toxicity. [ 78 ]…”