“…Drug-based migraine prevention, especially when examined in the in the light of the possible models of the pathogenesis of migraine has been extensively reviewed [Adelman and Adelman, 2001;Arulmozhi et al, 2005;Becker, 1999;Bigal et al, 2002;Cutrer, 2001;Goadsby, 2007;Limmroth and Michel, 2001;Peroutka, 1990;Ramadan et al, 1997;Sanches-del-Rio et al, 2006;Silberstein and Goadsby, 2002], summarized in Table 1. A useful summary of the original rationale for many preventative therapies can be gleaned from Lance and Goadsby [2005] and from Diener [2000].…”