Current options for the prevention and treatment of migraine

Looking in the wrong place? The search for an ideal migraine preventative

“…Drug-based migraine prevention, especially when examined in the in the light of the possible models of the pathogenesis of migraine has been extensively reviewed [Adelman and Adelman, 2001;Arulmozhi et al, 2005;Becker, 1999;Bigal et al, 2002;Cutrer, 2001;Goadsby, 2007;Limmroth and Michel, 2001;Peroutka, 1990;Ramadan et al, 1997;Sanches-del-Rio et al, 2006;Silberstein and Goadsby, 2002], summarized in Table 1. A useful summary of the original rationale for many preventative therapies can be gleaned from Lance and Goadsby [2005] and from Diener [2000].…”

Examination of the Evidence for Off-Label Use of Gabapentin

“…62 There was no mention of gabapentin in this guideline since published reports of gabapentin for these indications are limited to case reports, open-label studies, and anecdotal letters. [63][64][65][66][67] Thus, gabapentin cannot be recommended for use in any aspect of the management of alcohol withdrawal seizures, either as initial or add-on therapy.…”

Unmet Needs in the Treatment of Allergic Asthma: Potential Role of Novel Biologic Therapies

“…[63][64][65] For example, Suissa et al have reported the hospitalization rate and incidence of asthmarelated death are lower in patients who persist with continuous low-dose asthma therapy compared with those who do not. 66,67 Adherence rates for all medications prescribed for asthma therapy range from 30% to 70%. 64 In several reports, fewer than half of all patients prescribed inhaled medications adhered to their prescribed regimens.…”