Current Options for Second-Line Systemic Therapy in Metastatic Renal Cell Carcinoma

Mitsogiannis, Iraklis; Mitsogianni, Maria; Papathanassiou, Maria; Αναγνώστου, Μαρία; Tamposis, Ioannis; Mitrakas, Lampros; Samara, Maria; Tzortzis, Vassilios; Vlachostergios, Panagiotis J.

doi:10.15586/jkcvhl.v9i3.243

Cited by 7 publications

(5 citation statements)

References 104 publications

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“…On-site activation and differentiation of inflammatory macrophages result in the release of IL-1, thereby triggering immune responses from Th1-type cells that contribute to tissue damage [108][109][110]. In CKD, immune cells infiltrating the kidneys play a deleterious role, actively participating in the progression of the disease and leading to nephron loss and fibrosis [111][112][113]. Tseng et al [114] investigated the potential therapeutic effects of sesamol in addressing renal inflammation and reactive oxygen species (ROS)-mediated interleukin-1 beta (IL-1β) secretion.…”

Section: Sesamolmentioning

confidence: 99%

Sesame Seeds: A Nutrient-Rich Superfood

Mostashari,

Mousavi Khaneghah

2024

Foods

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Sesame seeds (Sesamum indicum L.) have been cultivated for thousands of years and have long been celebrated for their culinary versatility. Beyond their delightful nutty flavor and crunchy texture, sesame seeds have also gained recognition for their remarkable health benefits. This article provides an in-depth exploration of the numerous ways in which sesame seeds contribute to overall well-being. Sesame seeds are a powerhouse of phytochemicals, including lignans derivatives, tocopherol isomers, phytosterols, and phytates, which have been associated with various health benefits, including the preservation of cardiovascular health and the prevention of cancer, neurodegenerative disorders, and brain dysfunction. These compounds have also been substantiated for their efficacy in cholesterol management. Their potential as a natural source of beneficial plant compounds is presented in detail. The article further explores the positive impact of sesame seeds on reducing the risk of chronic diseases thanks to their rich polyunsaturated fatty acids content. Nevertheless, it is crucial to remember the significance of maintaining a well-rounded diet to achieve the proper balance of n-3 and n-6 polyunsaturated fatty acids, a balance lacking in sesame seed oil. The significance of bioactive polypeptides derived from sesame seeds is also discussed, shedding light on their applications as nutritional supplements, nutraceuticals, and functional ingredients. Recognizing the pivotal role of processing methods on sesame seeds, this review discusses how these methods can influence bioactive compounds. While roasting the seeds enhances the antioxidant properties of the oil extract, certain processing techniques may reduce phenolic compounds.

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Section: Sesamolmentioning

confidence: 99%

Sesame Seeds: A Nutrient-Rich Superfood

Mostashari,

Mousavi Khaneghah

2024

Foods

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“…This improvement can be attributed to significant advancements in treatment [3][4][5]. The treatment landscape is rapidly evolving, and there are currently several therapeutic options available for second-line therapy, including dual immune checkpoint inhibition (ICI) or a combination of immunotherapy ICIs and antiangiogenic tyrosine kinase inhibitors (TKI) [9].…”

Section: Introductionmentioning

confidence: 99%

“…One of the most widely used models is the Motzer score or Memorial Sloan Kettering Cancer Center (MSKCC) risk model, initially developed in the cytokine era and validated in molecular-targeted therapy [18,19]. Similarly, the International The treatment landscape is rapidly evolving, and there are currently several therapeutic options available for second-line therapy, including dual immune checkpoint inhibition (ICI) or a combination of immunotherapy ICIs and antiangiogenic tyrosine kinase inhibitors (TKI) [9].…”

Section: Introductionmentioning

confidence: 99%

Second-Line Treatment of Metastatic Renal Cell Carcinoma in the Era of Predictive Biomarkers

et al. 2023

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Background: Over the past few years, significant advancements have been achieved in the front-line treatment of metastatic renal cell carcinomas (mRCCs). However, most patients will eventually encounter disease progression during this front-line treatment and require further therapeutic options. While treatment choices for mRCCs patients are determined by established risk classification models, knowledge of prognostic factors in subsequent line therapy is essential in patient care. Methods: In this retrospective, single-center study, patients diagnosed with mRCCs who experienced progression after first-line therapy were enrolled. Fifteen factors were analyzed for their prognostic impact on survival using the Kaplan–Meier method and the Cox proportional hazards model. Results: Poor International Metastatic RCCs Database Consortium (IMDC) and Memorial Sloan-Kettering Cancer Center (MSKCC) risk scores, NLR value > 3, clinical benefit < 3 months from a therapeutic line, and the presence of sarcomatoid differentiation were found to be poor independent prognostic factors for shortened overall survival. Conclusions: This study provided new insights into the identification of potential prognostic parameters for late-line treatment in mRCCs. The results indicated that good IMDC and MSKCC prognostic scores are effective in second-line therapy. Moreover, patients with NLR < 3, no sarcomatoid differentiation, and clinical benefit > 3 months experienced significantly longer overall survival.

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“…Therefore, early diagnosis and detection of micrometastases are very important. In addition, there is still no precise targeted drug for patients with mRCC [7][8][9][10][11][12][13][14]. At the same time, the traditional imaging monitoring methods have poor real-time performance and poor sensitivity.In the last few years, treatment strategies for patients with advanced or metastatic renal cell carcinoma (mRCC) have developed rapidly.…”

Section: Introductionmentioning

confidence: 99%

Research Progress on Circulating Tumor DNA in Renal Cell Carcinoma

2023

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Renal cell carcinoma (RCC) is one of the most common tumors in urinary system, and its incidence ranks 7th and 8th in male and female in the United States with a continuous upward trend in last 5 years. In China, RCC also shows a significant growth trend. Because the early symptoms are not obvious, many patients are diagnosed at an advanced stage of the disease and often have a poor prognosis. Therefore, early diagnosis and treatment are particularly important for RCC control. With the advent of the era of innovation in imaging modalities, even early detection of RCC in patients is not possible. However, with the steady increase in the value of liquid biopsy and the emergence of Next-generation sequencing technology, the research on tumor genomics continues to advance, and sequencing combined with liquid biopsy is applied in solid tumors. With this merging, circulating tumor DNA (ctDNA) detection is becoming more and more mature, providing a new tool to resolve this problem. Circulating tumor DNA (ctDNA) is a tumor-derived fragment of DNA in blood or body fluids. It can reflect the information of the entire tumor genome and is easy to obtain. ctDNA has important clinical application in tumor diagnosis, prognosis, and monitoring of disease recurrence, therapeutic effect and chemotherapy resistance. Recent studies show that ctDNA also have clinical value in RCCS as circulating tumor DNA detection may serve as a biomarker for early diagnosis, and monitoring disease course. This article reviews the application of ctDNA in the clinical diagnosis and treatment of RCCS.

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Current Options for Second-Line Systemic Therapy in Metastatic Renal Cell Carcinoma

Cited by 7 publications

References 104 publications

Sesame Seeds: A Nutrient-Rich Superfood

Sesame Seeds: A Nutrient-Rich Superfood

Second-Line Treatment of Metastatic Renal Cell Carcinoma in the Era of Predictive Biomarkers

Research Progress on Circulating Tumor DNA in Renal Cell Carcinoma

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