Current management of epithelial ovarian carcinoma: A review

Abstract

Epithelial carcinoma of the ovary is the most lethal of gynaecological malignancies and it affects about one in 70 women in developed countries. Over 75% of women with the disease have tumour spread beyond the pelvis at the time of diagnosis, and their treatment requires the appropriate use of surgery and chemotherapy. The strategies used in the treatment of ovarian cancer are constantly evolving. An overview of current treatment regimens and their evolution is provided, with particular emphasis on the interdependence of surgery and chemotherapy in the optimal management of the disease. Semin. Surg. Oncol. 19:11–19, 2000. © 2000 Wiley‐Liss, Inc.

Uterine metastases in ovarian carcinoma: frequency and survival in women who underwent hysterectomy

“…[1][2][3][4] In most autopsy reports from the last 3 decades that deal with the metastatic pattern of EOC the uterus is not listed as a metastatic site [6][7][8][9][10] probably because the patients underwent a hysterectomy before they died of the disease. In only one study of 100 autopsies of ovarian cancer 11 it is reported that the uterine serosa, the myometrium and the cervix were involved in 27%, 10%, and 3% respectively.…”

Uterine metastases in ovarian carcinoma: frequency and survival in women who underwent hysterectomy

“…[1][2][3][4] In most autopsy reports from the last 3 decades that deal with the metastatic pattern of EOC the uterus is not listed as a metastatic site [6][7][8][9][10] probably because the patients underwent a hysterectomy before they died of the disease. In only one study of 100 autopsies of ovarian cancer 11 it is reported that the uterine serosa, the myometrium and the cervix were involved in 27%, 10%, and 3% respectively.…”

Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel

“…Ovarian cancer detection, prognosis and response to treatment are currently based on quantification of serum levels of CA125 and imaging modalities (Van der Berg et al, 1988;Marsden et al, 2000;Meyer and Rustin, 2000). However, the clinical value of CA125 as a marker of ovarian cancer is low, due to its expression in non-malignant or non-ovarian malignant conditions (Tuxen et al, 1995;Meyer and Rustin, 2000).…”

The clinical significance of malignant pleural effusions in patients with optimally debulked ovarian carcinoma

“…15 All patients diagnosed with what appears to be resectable disease undergo surgery with the intent of performing optimal abdominopelvic cytoreductive surgery. We believe that a maximal surgical effort should be employed, and we recently reported a statistically significant increase in optimal debulking rates at our institution by incorporating extensive upper abdominal procedures into our surgical approach.…”

Uterine metastases in ovarian carcinoma: frequency and survival in women who underwent hysterectomy

“…[1][2][3][4] In most autopsy reports from the last 3 decades that deal with the metastatic pattern of EOC the uterus is not listed as a metastatic site [6][7][8][9][10] probably because the patients underwent a hysterectomy before they died of the disease. In only one study of 100 autopsies of ovarian cancer 11 it is reported that the uterine serosa, the myometrium and the cervix were involved in 27%, 10%, and 3% respectively.…”

Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel

“…Ovarian cancer detection, prognosis and response to treatment are currently based on quantification of serum levels of CA125 and imaging modalities (Van der Berg et al, 1988;Marsden et al, 2000;Meyer and Rustin, 2000). However, the clinical value of CA125 as a marker of ovarian cancer is low, due to its expression in non-malignant or non-ovarian malignant conditions (Tuxen et al, 1995;Meyer and Rustin, 2000).…”

The clinical significance of malignant pleural effusions in patients with optimally debulked ovarian carcinoma

“…15 All patients diagnosed with what appears to be resectable disease undergo surgery with the intent of performing optimal abdominopelvic cytoreductive surgery. We believe that a maximal surgical effort should be employed, and we recently reported a statistically significant increase in optimal debulking rates at our institution by incorporating extensive upper abdominal procedures into our surgical approach.…”

Uterine metastases in ovarian carcinoma: frequency and survival in women who underwent hysterectomy

“…[1][2][3][4] In most autopsy reports from the last 3 decades that deal with the metastatic pattern of EOC the uterus is not listed as a metastatic site [6][7][8][9][10] probably because the patients underwent a hysterectomy before they died of the disease. In only one study of 100 autopsies of ovarian cancer 11 it is reported that the uterine serosa, the myometrium and the cervix were involved in 27%, 10%, and 3% respectively.…”

Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel

“…Ovarian cancer detection, prognosis and response to treatment are currently based on quantification of serum levels of CA125 and imaging modalities (Van der Berg et al, 1988;Marsden et al, 2000;Meyer and Rustin, 2000). However, the clinical value of CA125 as a marker of ovarian cancer is low, due to its expression in non-malignant or non-ovarian malignant conditions (Tuxen et al, 1995;Meyer and Rustin, 2000).…”

The clinical significance of malignant pleural effusions in patients with optimally debulked ovarian carcinoma

“…15 All patients diagnosed with what appears to be resectable disease undergo surgery with the intent of performing optimal abdominopelvic cytoreductive surgery. We believe that a maximal surgical effort should be employed, and we recently reported a statistically significant increase in optimal debulking rates at our institution by incorporating extensive upper abdominal procedures into our surgical approach.…”