Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Koppes, Sjors A.; Engebretsen, Kristiane A.; Agner, Tove; Angelova-Fischer, Irena; Berents, Teresa Løvold; Brandner, Johanna M.; Brans, Richard; Clausen, Maja‐Lisa; Hummler, Edith; Jakaša, Ivone; Jurakic-Toncic, Ružica; John, Swen Malte; Khnykin, Denis; Molin, Sonja; Holm, Jan Øivind; Suomela, Sari; Thierse, Hermann‐Josef; Kežić, Sanja; Martin, Stefan F.; Thyssen, Jacob P.

doi:10.1111/cod.12789

Cited by 69 publications

(59 citation statements)

References 169 publications

(231 reference statements)

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“…There is some evidence that increased TEWL can be an indicator of individual susceptibility to the development of contact dermatitis, 25 and of early development of hand dermatitis related to occupational exposure to irritants. [26][27][28] In this study, both frequent hand washing and an established greater exposure of apprentices to skin hazards in the Zagreb region were confirmed as predictors that were positively associated with hand and forearm TEWL values in multiple linear regression models. In other words, apprentices from Zagreb and those who frequently washed their hands had higher hand and forearm TEWL values.…”

Section: Skin Symptoms and Tewlsupporting

confidence: 62%

Factors related to skin health in hairdressing apprentices from two Croatian regions

et al. 2019

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Background Hairdressing apprentices are at high risk for developing occupational contact dermatitis. Objectives The objective of this study was to analyse whether there are differences in skin health, skin protection and health‐related quality of life between apprentices from two Croatian regions (Zagreb and Dalmatia). Materials and methods Final‐year hairdressing apprentices from Zagreb (n = 101) and Dalmatia (n = 77) were enrolled in the study. Clinical examination of hands was performed by use of the Osnabrück Hand Eczema Severity Index. Transepidermal water loss (TEWL) was measured on forearm and hand. A history of self‐reported skin symptoms, work‐related exposure to skin hazards and health‐related quality of life were assessed with validated questionnaires. Results Apprentices from Zagreb reported having been engaged in practical work more days per month than Dalmatian apprentices (median 12 days vs 8 days, respectively, P < 0.001), and washing their hands >20 times per day more frequently (28% vs 10%, respectively, P = 0.004), and consequently more frequently having dry hands (37% vs 16%, respectively, P = 0.002), and significantly higher TEWL values on the hand and forearm, which was confirmed by the results obtained with multiple linear regression models. Conclusions A higher extent of exposure to skin hazards was related to poorer skin barrier function, which confirms the need for improvement of appropriate safety practices in hairdressing schools.

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Section: Skin Symptoms and Tewlsupporting

confidence: 62%

Factors related to skin health in hairdressing apprentices from two Croatian regions

et al. 2019

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“…Defects in the FLG biochemistry are found in the majority of patients with atopic dermatitis (AD), a disease associated with dry skin. A reduction of NMF may also be caused by contact irritants, whose action cannot be assigned to a loss of FLG …”

Section: How To Avoid a Skin Biopsy?mentioning

confidence: 99%

Assessing the skin barrier via corneocyte morphometry

Riethmüller

2018

Experimental Dermatology

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The skin barrier is an inevitable physiological function. Virtually all skin diseases exhibit an altered barrier. Because of its diversity, this vital function cannot be assessed adequately by a single method. Preference in both pharmaceutical and cosmetic testing is given to noninvasive assays, mostly macroscopic methods like optical or electrical or mechanical measurements. The present review focuses on advances in ultrastructural assays based on corneocytes obtained via tape stripping-highlighting candidates for automated processing. Among these are electron microscopic (EM) and atomic force microscopic (AFM) analyses, which are discussed with respect to clinical signs and skin hydration, as assessed by Raman spectroscopy or by concentration of natural moisturizing factor.

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“…3 † These observations suggest that the alterations in the corneocyte surface topography might be attributed to the skin barrier damage caused by the irritant, rather than to inflammation itself. 4 Therefore, we were interested in whether the changes in the DTI and NMF levels were SLS-specific or also occurred with other skin irritants.…”

Section: Introductionmentioning

confidence: 99%

Specific barrier response profiles after experimentally induced skin irritation in vivo

et al. 2018

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BackgroundRecently, natural moisturizing factors (NMFs) and corneocyte surface topography were suggested as biomarkers for irritant dermatitis.ObjectivesTo investigate how exposure to different irritants influences corneocyte surface topography, NMF levels and the barrier function of human skin in vivo.MethodsEight healthy adult volunteers were exposed to aqueous solutions of 60% n‐propanol, 0.5% sodium lauryl sulfate (SLS), 0.15% sodium hydroxide, and 2.0% acetic acid, and distilled water, in a repeated irritation test over a period of 96 hours. Erythema, transepidermal water loss (TEWL), skin hydration, the dermal texture index (DTI) and NMF levels were measured at baseline, and after 24 and 96 hours.ResultsSLS and sodium hydroxide had the most pronounced effects on erythema and TEWL. Although n‐propanol caused only slight changes in TEWL and erythema, it showed pronounced effects on skin hydration, NMF levels, and the DTI. NMF was the only parameter that was significantly altered by all investigated irritants. The changes in the DTI were inversely associated with NMF levels and skin hydration.ConclusionSkin barrier impairment and the inflammatory response are irritant‐specific, emphasizing the need for a multiparametric approach to the study of skin irritation. NMF levels seem to be the most sensitive parameter in detecting irritant‐induced skin barrier alterations.

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Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Cited by 69 publications

References 169 publications

Factors related to skin health in hairdressing apprentices from two Croatian regions

Factors related to skin health in hairdressing apprentices from two Croatian regions

Assessing the skin barrier via corneocyte morphometry

Specific barrier response profiles after experimentally induced skin irritation in vivo

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