Current knowledge and perspectives of potential impacts of Salmonella enterica on the profile of the gut microbiota

Abstract

In the past decade, the initial studies of the gut microbiota started focusing on the correlation of the composition of the gut microbiota and the health or diseases of the host, and there are extensive literature reviews pertaining to this theme. However, little is known about the association between the microbiota, the host, and pathogenic bacteria, such as Salmonella enterica, which is among the most important foodborne pathogens and identified as the source of multiple outbreaks linked to contaminated foods causing salmonellosis. Secretion systems, flagella, fimbriae, endotoxins, and exotoxins are factors that play the most important roles in the successful infection of the host cell by Salmonella. Infections with S. enterica, which is a threat to human health, can alter the genomic, taxonomic, and functional traits of the gut microbiota. The purpose of this review is to outline the state of knowledge on the impacts of S. enterica on the intestinal microbiota and highlight the need to identify the gut bacteria that could contribute to salmonellosis.

Manganese Utilization in Salmonella Pathogenesis: Beyond the Canonical Antioxidant Response

“…Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen associated with intestinal and invasive diseases in humans and animals ( Galan, 2021 ). The success of Salmonella as a pathogen can be directly ascribed to its capacity to overcome colonization resistance by resident gut microbiota, invade epithelial cells, and establish intracellular infections within host enterocytes and macrophages ( Winter and Bäumler, 2011 ; Lorkowski et al, 2014 ; Lhocine et al, 2015 ; Aljahdali et al, 2020 ; Jiang et al, 2021 ; Powers et al, 2021 ). During their associations with host cells, Salmonella are exposed to acid pH, oxidative and nitrosative stress, and nutritional deprivation ( Fang et al, 2016 ).…”

Play the plug: How bacteria modify recognition by host receptors?

“…A majority of gastrointestinal (GI) microbes form a complex bacterial community and maintain a commensal relationship with the host. Some bacterial species of the genera Escherichia, Shigella, Salmonella, Proteus and Yersinia constantly invade the host GI tract, the blood and vascular system and the genitourinary tract thereby causing and spreading infection (Dekker and Frank, 2015;Hamilton et al, 2018;Gu et al, 2019;Aljahdali et al, 2020;Ramos et al, 2020;Yang et al, 2020). Among various defense mechanisms, the formation of a mucus layer by the host cells in the gut acts as a natural barrier blocking foreign pathogens from invading the intestinal epithelial lining.…”

Efficacy and safety evaluation of acupuncture in the treatment of impaired glucose regulation

“…If no measures are taken to prevent the transition from prediabetes to diabetes, the number of diabetic patients in China will further increase. [ 9 – 11 ]…”

“…The prevalence of prediabetes in people over 20 years old in China is significantly higher than that in diabetic patients. If no measures are taken to prevent the transition from prediabetes to diabetes, the number of diabetic patients in China will further increase [9–11] …”

“…If no measures are taken to prevent the transition from prediabetes to diabetes, the number of diabetic patients in China will further increase. [9][10][11] At present, the treatment of patients with prediabetes in China mainly focuses on diet control and exercise to reduce the risk of The authors have no conflicts of interest to disclose.…”