Current Intraoperative Imaging Techniques to Improve Surgical Resection of Laryngeal Cancer: A Systematic Review

Lauwerends, Lorraine J.; Galema, Hidde A.; Hardillo, José A.; Sewnaik, Aniel; Monserez, Dominiek; Driel, Pieter B A A van; Verhoef, Cornelis; Jong, Robert J. Baatenburg de; Hilling, Denise E.; Keereweer, Stijn

doi:10.3390/cancers13081895

Cited by 30 publications

(19 citation statements)

References 72 publications

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“…In this section attention is paid prevalently to the biomolecules acting as endogenous fluorophores and to their possible pathophysiological meaning, rather than on the almost countless clinical optically based diagnostic applications described in dedicated papers and reviews [264][265][266][267][268][269][270][271][272][273].…”

Section: Normal and Altered Cell And Tissuesmentioning

confidence: 99%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

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Organisms belonging to all life kingdoms may have the natural capacity to fluoresce. Autofluorescence events depend on the presence of natural biomolecules, namely endogenous fluorophores, with suitable chemical properties in terms of conjugated double bonds, aromatic or more complex structures with oxidized and crosslinked bonds, ensuring an energy status able to permit electronic transitions matching with the energy of light in the UV-visible-near-IR spectral range. Emission of light from biological substrates has been reported since a long time, inspiring unceasing and countless studies. Early notes on autofluorescence of vegetables have been soon followed by attention to animals. Investigations on full living organisms from the wild environment have been driven prevalently by ecological and taxonomical purposes, while studies on cells, tissues and organs have been mainly promoted by diagnostic aims. Interest in autofluorescence is also growing as a sensing biomarker in food production and in more various industrial processes. The associated technological advances have supported investigations ranging from the pure photochemical characterization of specific endogenous fluorophores to their possible functional meanings and biological relevance, making fluorescence a valuable intrinsic biomarker for industrial and diagnostic applications, in a sort of real time, in situ biochemical analysis. This review aims to provide a wide-ranging report on the most investigated natural fluorescing biomolecules, from microorganisms to plants and animals of different taxonomic degrees, with their biological, environmental or biomedical issues relevant for the human health. Hence, some notes in the different sections dealing with different biological subject are also interlaced with human related issues. Light based events in biological subjects have inspired an almost countless literature, making it almost impossible to recall here all associated published works, forcing to apologize for the overlooked reports. This Review is thus proposed as an inspiring source for Readers, addressing them to additional literature for an expanded information on specific topics of more interest.

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Section: Normal and Altered Cell And Tissuesmentioning

confidence: 99%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

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“…Although progress has been made in the comprehensive management of patients with LSCC, the 5‐year overall survival (OS) rate had reduced over the past 50 years, owing to the insidious symptoms and lack of effective diagnostic methods for early stages. 2 Approximately 60% of the patients with LSCC are diagnosed at an advanced stage or even with metastasis of the lymph node, and have had a poor prognosis. 3 Recently, more and more evidence has demonstrated that the prognosis and chemotherapeutic efficacy of patients with tumor was largely affected by the infiltration of the immune cells.…”

Section: Introductionmentioning

confidence: 99%

ITGA5 is an independent prognostic biomarker and potential therapeutic target for laryngeal squamous cell carcinoma

Zhou

Wei

Shen

et al. 2022

Clinical Laboratory Analysis

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Background Integrin α5 (ITGA5) was involved in a variety of cancers. However, the role of ITGA5 in laryngeal squamous cell carcinoma (LSCC) remains unknown. Methods The expression of ITGA5 and the corresponding clinicopathological parameters of LSCC patients the TCGA database. Five datasets (GSE51985, GSE59102, GSE84957, GSE27020, and GSE65858) were downloaded from the GEO database as validation sets. Kaplan–Meier plotter, Cox regression analysis, and nomogram were performed to determine the prognostic value of ITGA5 in LSCC. GO, KEGG, and GSEA were used to explore the underlying biological functions of ITGA5 in LSCC. The algorithms ESTIMATE and CIBERSORT were adopted to evaluate the association between ITGA5 and the infiltration of the immune cells. The algorithm pRRophetic was used to estimate the response to chemotherapeutic drugs. Results The expression of ITGA5 was higher in the LSCC samples and linked to poor overall survival and recurrence‐free survival. Further, the Cox regression analysis confirmed that high expression of ITGA5 was an independent unfavorable prognostic factor. The predictive performance of nomogram based on the expression of ITGA5 was accurate and practical. The functional enrichment analysis confirmed that ITGA5 was related to the construction of the components and structures of the extracellular matrix. Finally, patients with high ITGA5 expression were more likely to benefit from docetaxel and gemcitabine. Conclusion The expression of ITGA5 was elevated in the LSCC and was a predictor for prognosis and chemotherapeutic response in LSCC patients.

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“…In addition, due to the strong absorption of blue light by the optical characteristics of hemoglobin, NBI can also clearly display the submucosal microvascular morphology. The image provided by optical enhancement technology emphasizes the morphology and surface structure of mucosal blood vessels and enhances the visibility of blood vessels and other structures on the mucosal surface, which is conducive to the detection of lesions and enables it to obtain a visual effect similar to that of chemical staining under endoscopy [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Postoperative Examination of Laryngeal Malignant Tumor Based on Narrowband Imaging Resolution Enhancement Technology

Yang

Zhao

Lin

et al. 2022

Contrast Media & Molecular Imaging

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The application of endoscopic imaging in the biopsy of malignant laryngeal lesions is one of the current research hotspots in the medical field. Based on the narrowband imaging resolution enhancement technology, a model for postoperative examination of laryngeal malignant tumor was constructed in this paper. The article calculated the biopsy detection rate of malignant lesions and the correct biopsy detection rate of the two groups and made a statistical comparison. In the NBI mode group, the mucosal morphology and superficial mucosal microvascular morphology of the same lesion under two different modes of white light and NBI were compared, which solved the problem of data processing of cases. During the case comparison process, patients who needed biopsies to be sent for pathology were selected for inclusion in the study and were randomly divided into two groups. The coincidence rate of EUS combined with NBI diagnosis was significantly higher than that of ordinary white light gastroscopy (47.92%), and the difference was statistically significant ( P = 0.000 < 0.05 ). The experimental results compared the accuracy of the normal white light mode and the NBI mode to diagnose the nature of the lesions: according to the Kudo classification criteria, 23 cases of tumor lesions were to be diagnosed in the normal white light mode, with an accuracy rate of 69.70%, and the NBI mode was to be used to diagnose tumors. There were 81 cases of sexual lesions, with an accuracy rate of 93.94%. The NBI mode was more accurate in diagnosing the nature of the lesions under the Kudo classification standard ( P < 0.05 ). In 64 cases, the accuracy rate was 63.63%. Under the NBI mode, 29 cases of tumor lesions were proposed to be diagnosed, and the accuracy rate was 87.88% to promote the application of NBI endoscopy in the biopsy of malignant laryngeal lesions.

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Current Intraoperative Imaging Techniques to Improve Surgical Resection of Laryngeal Cancer: A Systematic Review

Cited by 30 publications

References 72 publications

Light and Autofluorescence, Multitasking Features in Living Organisms

Light and Autofluorescence, Multitasking Features in Living Organisms

ITGA5 is an independent prognostic biomarker and potential therapeutic target for laryngeal squamous cell carcinoma

Postoperative Examination of Laryngeal Malignant Tumor Based on Narrowband Imaging Resolution Enhancement Technology

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