Current insight into the functions of microRNAs in common human hair loss disorders: a mini review

Paul, Sujay; Licona-Vázquez, Iván; Serrano-Cano, Francisco I; Frías-Reid, Natalia; Pacheco-Dorantes, Carolina; Pathak, Surajit; Chakraborty, Samik; Srivastava, Aashish

doi:10.1007/s13577-021-00540-0

Cited by 18 publications

(12 citation statements)

References 69 publications

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“…Thus, DKK1 appears to be the key target molecule for studies that will focus on strategies of Wnt/β-catenin signaling augmentation in DP cells of AGA. Interestingly, a number of miRNAs is involved in the regulation of hair growth [ 42 ], and impairment of Wnt/β-catenin signaling negatively affects normal hair cycling [ 2 ]. This raises the idea of using certain miRNAs for modulating hair growth via regulating the Wnt/β-catenin signaling pathway.…”

Section: The Importance Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.

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Section: The Importance Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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“…The cancer hallmarks include six biological capabilities acquired during the multistep development of tumorigenesis and carcinogenesis, including evading growth suppressors, sustaining proliferative signaling, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis (Fouad & Aanei, 2017; X. Zhang et al, 2019). In this context, cellular pathways, especially those controlling cell proliferation, differentiation, and survival, have been shown to be regulated by miRNAs (Paul et al, 2021; Paul, Bravo Vázquez, Pérez Uribe, Roxana Reyes‐Pérez, & Sharma, 2020; Treiber et al, 2019). In almost all cancer types, dysregulation of miRNA expression has been reported (Khan et al, 2019).…”

Section: Phytochemicals Mediated Modulation Of Different Mirnas In Ca...mentioning

confidence: 99%

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

Ruiz‐Manriquez

Estrada-Meza

Benavides‐Aguilar

et al. 2021

Phytotherapy Research

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MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways, as well as their expression and function are tightly regulated in physiological homeostasis. Additionally, the dysregulation of these ncRNAs seems to be crucial to the pathogenesis of human diseases. The latest findings indicate that ncRNAs execute vital roles in cancer initiation and progression, and the cancer phenotype can be reversed by modulating their expression. Available scientific discoveries suggest that phytochemicals such as polyphenols, alkaloids, terpenoids, and organosulfur compounds can significantly modulate multiple cancer-associated miRNAs and lncRNAs, thereby inhibiting cancer initiation and development. However, despite promising outcomes of experimental research, only a few clinical trials are currently being conducted to evaluate the therapeutic effectiveness of these compounds. Nevertheless, understanding phytochemical-mediated ncRNA regulation in cancer and the underlying molecular mechanisms on tumor pathophysiology can aid in the development of novel therapeutic strategies to combat this deadly disease.

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“…MiRNAs are a family of small (21–25 nucleotides in length) non-coding regulatory RNAs that control the expression of genes at the post-transcriptional level [ 15 , 16 , 17 , 18 ]. Since their discovery in Caenorhabditis elegans by Lee et al [ 19 ], they have been found to be widely distributed in most of the eukaryotic organisms [ 20 ], and to date, ~2300 mature miRNAs have been associated with humans regulating almost 60% of genes [ 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers

Ruiz‐Manriquez

Pacheco

Medina‐Gomez

et al. 2022

Genes

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miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluid-filled sacs in the body, and though most cysts are benign, they can grow inside tumors and turn malignant. Recent evidence has revealed that the aberrant expression of a number of miRNAs present in extracellular fluids, including plasma or serum, urine, saliva, follicular fluid, and semen, contribute to different cystic pathologies. This review aims to describe the role of different miRNAs in three worldwide relevant cystic diseases: polycystic ovarian syndrome (PCOS), polycystic kidney disease (PKD), and pancreatic cyst tumors (PCTs), as well as their potential use as novel biomarkers.

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Current insight into the functions of microRNAs in common human hair loss disorders: a mini review

Cited by 18 publications

References 69 publications

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers

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