Curly Hair and Lipodystrophy as a Result of Highly Active Antiretroviral Treatment?

Colebunders, R

doi:10.1001/archderm.136.8.1064

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…This very simple method, whose robustness has been proven, can be an additional tool to assess of natural curliness, but also to follow the related alteration of hair curliness disease 7,8 or medicine 9–12 …”

Section: Resultsmentioning

confidence: 99%

Worldwide diversity of hair curliness: a new method of assessment

et al. 2007

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This study has shown that it is possible to classify the various hair types found worldwide into eight main groups. The approach involves objective descriptors of hair shape, and is more reliable than traditional methods relying on categories such as curly, wavy, and kinky. Applied to worldwide human diversity, it avoids reference to the putative, unclear ethnic origin of subjects. Briefly, a straight hair type I is just that, and whether it originates from a Caucasian or an Asian subject is not at issue. The hair types defined here also more adequately reflect the large variation of hair shape diversity around the world, and may possibly help to trace past mixed origins amongst human subgroups.

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Section: Resultsmentioning

confidence: 99%

Worldwide diversity of hair curliness: a new method of assessment

et al. 2007

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“…The proposed pathologic mechanism for indinavir‐induced alopecia is an alteration of the hair cycle induced by a disturbance on the retinoid metabolism, leading to a reversible loss of telogenic hairs 18 . Retinoid‐like side effects as cheilitis, dry skin, paronychia, lipodystrophy, and alopecia are expected in indinavir‐treated patients because of the homologies between amino acids sequences of retinoic acid‐binding protein 1 (RABP‐1) and the catalytic site of HIV‐1 protease, the target of protease inhibitors 18–20 . However, indinavir‐induced alopecia has no relation with other retinoid‐like mucocutaneous manifestations, drug dosage, or CD4 cell counts, suggesting the possibility that this interference with the retinoid metabolism may not be sole pathogenic mechanism of this drug‐induced alopecia 21 .…”

Section: Discussionmentioning

confidence: 99%

Stem cell apoptosis in HIV‐1 alopecia

et al. 2006

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Our study demonstrated that diffuse alopecia related to HIV-1 infection represents a hair cycle disturbance and that part of the follicular stem cell population become apoptotic in a higher proportion than normal subjects. We found no cytotoxic folliculitis. Owing to its cell-cycle interaction and caspase-induction capacities, we propose HIV-1 viral protein R as a possible follicular stem cell apoptosis inductor.

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“…The predominant cutaneous findings of indinavir therapy are retinoid‐like effects; lipodystrophy occurs in a smaller proportion of patients on indinavir. The retinoid‐like manifestations of recurrent paronychia (47), pyogenic granulomas (48), curly hair (49), and alopecia (50,51) can occur with indinavir. Indinavir‐related alopecia may be diffuse or patchy.…”

Section: Protease Inhibitorsmentioning

confidence: 99%

Cutaneous effects of highly active antiretroviral therapy in HIV-infected patients

Kong

Myers

2005

Dermatol Ther

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Effective highly active antiretroviral therapy (HAART) has increased survival in patients infected with the human immunodeficiency virus (HIV). However, HAART is not without toxicities. Cutaneous adverse reactions from antiretroviral agents have become increasingly important to recognize as the population of patients surviving with HIV infection grows. Dermatologists play an important role in managing these cutaneous effects of HAART therapy in HIV patients. This article reviews cutaneous adverse effects from nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, and fusion inhibitors, as well as separately addresses lipodystrophy, and immune reconstitution.

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Curly Hair and Lipodystrophy as a Result of Highly Active Antiretroviral Treatment?

Cited by 14 publications

References 4 publications

Worldwide diversity of hair curliness: a new method of assessment

Worldwide diversity of hair curliness: a new method of assessment

Stem cell apoptosis in HIV‐1 alopecia

Cutaneous effects of highly active antiretroviral therapy in HIV-infected patients

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