volume 24, issue s2, P33-42 2011
DOI: 10.3233/jad-2011-102100
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Daijiro Yanagisawa, Hiroyasu Taguchi, Akitsugu Yamamoto, Nobuaki Shirai, Koichi Hirao, Ikuo Tooyama

Abstract: Studies of Alzheimer's disease (AD) strongly support the hypothesis that amyloid-β (Aβ) deposition in the brain is the initiating event in the progression of AD. Aβ peptides easily form long insoluble amyloid fibrils, which accumulate in deposits known as senile plaques. On the other hand, recent work indicated that soluble Aβ oligomers, rather than monomers or insoluble Aβ fibrils, might be responsible for neuronal and synaptic dysfunction in AD. Curcumin, a low molecular weight yellow-orange pigment derived …

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