Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1α and caspase-3 mechanisms

Ye, Ming-Xiang; Zhao, Yilin; Li, Yan; Miao, Qing; Li, Zhikui; Ren, Xue; Song, Liqiang; Yin, Hong; Zhang, Jian

doi:10.1016/j.phymed.2012.03.005

Cited by 96 publications

(67 citation statements)

References 26 publications

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“…It has been already verified in many studies that curcumin has many medical characteristics, as can be demonstrated in animal experiments and molecular biological studies. [18][19][20][21] Curcumin has anti-inflammatory properties through suppressing cyclooxygenase-2 (COX-2) and cytokines, 22,23 prevents tumor metastasis by blocking matrix metalloproteinases (MMP-2 and MMP-9), 24,25 and can regulate the activation of Bcl-2 and caspases, thus inducing cancer cells to an apoptotic program. 26,27 In addition, curcumin can inhibit the transcriptional activation of nuclear factor κB and activating protein-1 to reduce inflammation and tumor hyperplasia.…”

mentioning

confidence: 99%

Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway

et al. 2015

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Hypotheses. Epithelial-mesenchymal transition (EMT) and invasion play a critical role in cancer progression and metastasis. We have shown that low E-cadherin and high Twist expression are significantly correlated with prognostic survival prediction in oral squamous cell carcinoma (OSCC). This study aimed to determine the anti-invasive effect of curcumin on the expression of matrix metalloproteinases (MMPs) and of EMT regulators in OSCC. Methods. SCC-25 cells were treated with curcumin, and cell proliferation, invasion, and expression of MMPs and EMT regulators were assessed for cell viability by trypan blue exclusion, for invasion by Matrigel invasion chamber, and for EMT regulators and MMP changes in the levels of proteins by immunoblotting. Results. Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression. Conclusion. Curcumin has the potential to become an adjunctive regimen for the prevention of cancer progression and metastasis in oral cancer.

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mentioning

confidence: 99%

Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway

et al. 2015

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“…Noteworthy, the resistant cell sub-line HL-60/CDDP not only demonstrated higher sensitivity to DPPC:CHOL:pI-pAA:BEC-X:Curcumin, but also more marked apoptotic DNA-fragmentation and activation of both caspase-9 and caspase-8. These findings are of special interest since curcumin has been reportedly effective in restoring the responsiveness of resistant cells to cisplatin (Chen et al, 2014;Roy and Mukherjee, 2014;Ye et al, 2012) and even more has been shown to reduce the adverse clastogenic effects of this drug (Alaikov et al, 2007), which makes this plant polyphenol an advantageous candidate for combination regimens with the platinum drug.…”

Section: Discussionmentioning

confidence: 99%

Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

Jelezova

Drakalska

Momekova

et al. 2015

European Journal of Pharmaceutical Sciences

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Curcumin is a perspective drug candidate with pleiotropic antineoplastic activity, whose exceptionally low aqueous solubility and poor pharmacokinetic properties have hampered its development beyond the preclinical level. A possible approach to overcome these limitations is the encapsulation of curcumin into nano-carriers, incl. liposomes. The present contribution is focused on feasibility of using hybrid pH-sensitive liposomes, whereby curcumin is entrapped as a free drug and as a water soluble inclusion complex with PEGylated tertbutylcalix[4]arene, which allows the drug to occupy both the phospholipid membranes and the aqueous core of liposomes. The inclusion complexes were encapsulated in dipalmithoylphosphathydilcholine:cholesterol liposomes, whose membranes were grafted with a poly(isoprene-b-acrylic acid) diblock copolymer to confer pH-sensitivity. The liposomes were characterized by DLS, ζ-potential measurements, cryo-TEM, curcumin encapsulation efficacy, loading capacity, and in vitro release as a function of pH. Free and formulated curcumin were further investigated for cytotoxicity, apoptosis-induction and caspase-8, and 9 activation in chemosensitive HL-60 and its resistant sublines HL-60/Dox and HL-60/CDDP. Formulated curcumin was superior cytotoxic and apoptogenic agent vs. the free drug. The mechanistic assay demonstrated that the potent proapoptotic effects of pH-sensitive liposomal curcumin presumably mediated via recruitment of both extrinsic and intrinsic apoptotic pathways in both HL-60 and HL-60/CDDP cells.

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“…In A549 lung adenocarcinoma cells, curcumin has been shown to reverse cisplatin resistance through HIF-1α-mediated p-gp down-regulation (Ye et al, 2012). In multidrug resistant human cervical carcinoma KB-V1 cells, curcumin decreased the mRNA expression of MDR1 and protein expression of p-gp in a dose-and time-dependent manner.…”

Section: Curcuminmentioning

confidence: 97%

“…Recent research has shown that more consumption of vegetables and fruits can prevent 20% incident of cancer and about 200,000 cancer related deaths annually (Pratheeshkumar et al, 2012). Other studies have shown that phytochemicals derived from fruits, vegetables, and spices have a great potential to enhance sensitivity of cancer cells to anticancer drugs (Borska et al, 2012;Ye et al, 2012;Kim et al, 2014). A food or a part of food that provide medical and health benefits including the prevention and/or treatment of a disease is called as Nutraceutical (Aggarwal et al, 2009).…”

Section: Enhancing Activity Of Anticancer Drugs In Multidrug Resistanmentioning

confidence: 99%

Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals

Khan¹,

Maryam²,

Mehmood³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Multidrug resistance is a principal mechanism by which tumors become resistant to structurally and functionally unrelated anticancer drugs. Resistance to chemotherapy has been correlated with overexpression of p-glycoprotein (p-gp), a member of the ATP-binding cassette (ABC) superfamily of membrane transporters. P-gp mediates resistance to a broad-spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively expelling the drugs from cells. Use of specific inhibitors/blocker of p-gp in combination with clinically important anticancer drugs has emerged as a new paradigm for overcoming multidrug resistance. The aim of this paper is to review p-gp regulation by dietary nutraceuticals and to correlate this dietary nutraceutical induced-modulation of p-gp with activity of anticancer drugs.

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Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1α and caspase-3 mechanisms

Cited by 96 publications

References 26 publications

Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway

Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway

Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals

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