Curcumin-loaded sandwich-like nanofibrous membrane prepared by electrospinning technology as wound dressing for accelerate wound healing

Chen, Kai; Pan, Hao; Ji, Dongxu; Li, Yunjian; Duan, Hongliang; Pan, Weisan

doi:10.1016/j.msec.2021.112245

Cited by 80 publications

(65 citation statements)

References 52 publications

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“…Aghamohamadi et al (2018) fabricated an anti-bacterial fiber from Aloe vera and polyvinyl pyrrolidone, confirming the in vitro antimicrobial activity, thereby recommending it for wound healing applications [48]. Recently, Chen et al (2021) loaded curcumin into nanofiber membranes by electrospinning technique [49]. The biomaterial showed accelerate wound healing, antimicrobial activity, and hemostatic effect in vivo, corroborating the assumption that electrospinning is indeed a promising technology for the advanced treatment of wounds.…”

Section: Electrospinning Scaffolds and Nanofibers Fabricationmentioning

confidence: 88%

Section: Electrospinning Scaffolds and Nanofibers Fabricationmentioning

confidence: 99%

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Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

et al. 2021

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The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanical properties of these films. On the other hand, many lipids have healing, antimicrobial, anti-inflammatory, anti-aging properties, among others, that make them even more interesting for application in the medical-pharmaceutical field. This manuscript discusses the production methods of these films both on a laboratory and at industrial scales, the properties of the developed biopolymers, and their advantages for the development of dermatologic and cosmetic products.

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Section: Electrospinning Scaffolds and Nanofibers Fabricationmentioning

confidence: 88%

Section: Electrospinning Scaffolds and Nanofibers Fabricationmentioning

confidence: 99%

Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

et al. 2021

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“…Unfortunately, the use of curcumin is limited by its low bioavailability, rapid metabolism, poor solubility, and light sensitivity [ 152 ]. A large number of recent papers [ 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 ] reported the incorporation of curcumin into nanocomposite materials such as nanofibers, nanoparticles, hydrogels, or novel combinations of these. Recently, numerous researchers have developed biocompatible and biodegradable composite nano-fibrous materials and hydrogel systems containing curcumin for wound healing applications, for example as an anti-scar or in chronic wounds [ 166 , 169 ].…”

Section: Natural Herbals and Spices In Wound Healingmentioning

confidence: 99%

“…Recently, numerous researchers have developed biocompatible and biodegradable composite nano-fibrous materials and hydrogel systems containing curcumin for wound healing applications, for example as an anti-scar or in chronic wounds [ 166 , 169 ]. These scaffold systems include polyvinyl pyrrolidone (PVP) [ 169 ], cerium nitrate hexahydrate (Ce(NO3)3·6H2O) [ 170 ], nanofibers of carboxymethyl guargum (CMGG) [ 171 ], electrospun amine-functionalized SBA-15 (Santa Barbara Amorphous) incorporated with PVA (Poly Vinyl Alcohol) [ 172 ], nanofibers of cellulose acetate (CA) integrated with graphene oxide, TiO2 [ 173 ], electrospun fibers comprising SBA-15 (Santa Barbara Amorphous), amine-functionalized SBA-15 polycaprolactone (PCL) [ 174 ], nanofibers of electrospun poly(ε-caprolactone) (PCL), Chitosan (CS) [ 175 ], thermo-sensitive sodium alginate hydrogel cross-linked with poly(N-isopropylacrylamide), and curcumin (Alg-g-pNIPAM) copolymers [ 176 ]. All these nanofibrous scaffolds exhibited high porosity and biocompatible characteristics that enhance the solubility of this hydrophobic drug, aiding its release in a controlled manner [ 176 ].…”

Section: Natural Herbals and Spices In Wound Healingmentioning

confidence: 99%

“…The curcumin-loaded nanofibrous membrane in the mid-layer released curcumin, therefore reducing wound oxidative stress and inflammation. Finally, the top layer, consisting of Ag nanoparticles, silk fibroin, and PCL, released Ag nanoparticles, which acted against external bacteria [ 176 ]. In a further study, when the eggshell membrane, a highly proteinaceous thin layer present between the egg white and shell, was added to the bottom layer made up of PVA with curcumin nanoparticles, antioxidant and anti-inflammatory action was implemented with positive effects on the migration of dermal fibroblasts [ 177 ].…”

Section: Natural Herbals and Spices In Wound Healingmentioning

confidence: 99%

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Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

et al. 2022

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Wound healing is a complicated process, and the effective management of wounds is a major challenge. Natural herbal remedies have now become fundamental for the management of skin disorders and the treatment of skin infections due to the side effects of modern medicine and lower price for herbal products. The aim of the present study is to summarize the most recent in vitro, in vivo, and clinical studies on major herbal preparations, their phytochemical constituents, and new formulations for wound management. Research reveals that several herbal medicaments have marked activity in the management of wounds and that this activity is ascribed to flavonoids, alkaloids, saponins, and phenolic compounds. These phytochemicals can act at different stages of the process by means of various mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulating, cell proliferation, and angiogenic effects. The application of natural compounds using nanotechnology systems may provide significant improvement in the efficacy of wound treatments. Increasing the clinical use of these therapies would require safety assessment in clinical trials.

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Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Xiong

Qian

Lü

et al. 2023

Adv Funct Materials

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Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing physical and mental challenges for patients due to the lack of efficient curative therapy. Despite considerable advances in pharmacological and surgical approaches, clinical trials for DFU patients remain disappointing due to the local overactive and excessive inflammation. Immunomodulatory hydrogels has significant advantages to overcome the clinical challenge of DFUs therapy. Here, recent fabrication and regenerative advances in the utilization of functional hydrogels for altering the immune microenvironment of DFUs are comprehensively reviewed. The pathological features and the healing processes of DFUs, followed by summarizing the physicochemical properties essential for the design of regenerative hydrogels for immunomodulation in DFUs, are briefly introduced. Then, the potential immuno-therapeutic modalities of hydrogels and emerging trends used to treat DFUs via multitherapeutic approaches and enhanced efficacy and safety are discussed. Taken together, by linking the structural properties of hydrogels to their functions in DFU therapy with a particular focus on immunomodulatory stimuli, this review can promote further advances in designing advanced hydrogels for DFUs, resulting in improved diabetic wound repair through translation into clinical setting in the near future.

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Curcumin-loaded sandwich-like nanofibrous membrane prepared by electrospinning technology as wound dressing for accelerate wound healing

Cited by 80 publications

References 52 publications

Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

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