Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis

Лю, Лэй; Sun, Lu; Wu, Qinjie; Guo, Wenhao; Li, Ling; Chen, YiShan; Li, Yuchen; Gong, Changyang; Zhang, Qian; Wei, Yuquan

doi:10.1016/j.ijpharm.2012.12.032

Cited by 148 publications

(78 citation statements)

References 26 publications

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“…The more micelles can circulate in blood for a longer period, the greater their accumulation in tumor may occur. The possible reason was that micelles coated with hydrophilic polymer had a reduced opsonization and a longer period in circulation (Liu et al, 2012;Wang et al, 2012b). High mobility of linear poly (ethylene oxide) chains in LDMP-2 might present to repel approaching proteins from the particle surface because the protein does not have sufficient contact time with the mobile chains (Ghosh & Ryan, 2013), which delayed the residence time of CUR in blood.…”

Section: Pharmacokinetics Of Cur Micellesmentioning

confidence: 99%

Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin

et al. 2014

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(2015) Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin, Drug Delivery, 22:1, 58-68, DOI: 10.3109/10717544.2014 Methods: A novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly ("-caprolactone) copolymer was synthesized through O-alkylation, basic hydrolysis and ring-opening polymerization reaction with methoxy-poly (ethylene glycol), epichlorohydrin and "-caprolactone as raw materials. Its structure was characterized by 1 H-NMR and GPC. The copolymer's hemolysis and micellar encapsulation for curcumin by thin-film hydration were studied. Curcumin-loaded micelles were evaluated by use of in vitro release, FT-IR and X-ray diffraction. Curcumin-loaded micelles' in vitro cytotoxic activities against Hela and HT-29 cells were done, and its pharmacokinetic parameters were also carried out. Results: Curcumin was encapsulated into the micelles with 92.54% of entrapment efficiency and 12.84% of drug loading in amorphous forms. The dissolubility of nanoparticulate curcumin was 1.70 Â 10 5 times higher than that of curcumin in water. The obtained copolymer showed no hemolysis. In vitro drug release study indicated that, in all cases, the kinetics was adjusted well to the Makoid-Banakar model (R 2 abj ¼ 0.9984). In addition, data were analyzed by the Korsmeyer-Peppas model, n values were 0.43, indicating that the drug release was accomplished by the combination diffusion and polymer chain relaxation. The cytotoxicity experiment indicated that the nanoparticulate curcumin kept up its potent anti-cancer activities. The pharmacokinetic results showed that the MRT 0-1 , t 1/2z and AUC 0-1 of Curcuminloaded micelles were 1.64, 6.54 and 4.67 times higher than that of CUR control solution. Conclusions: The copolymeric micelles loading curcumin might act as a delivery vehicle for CUR.

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Section: Pharmacokinetics Of Cur Micellesmentioning

confidence: 99%

Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin

et al. 2014

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“…A burst release behavior of cargo was often observed in the delivery systems of curcumin, which greatly impaired the utilization of curcumin [10,50]. As shown in Fig.…”

Section: Curcumin Release From Cur-npsmentioning

confidence: 99%

“…However, native curcumin has low solubility, physicochemical instability, poor bioavailability, rapid metabolism, and poor pharmacokinetics, which can severely hinder the clinical implication of native curcumin [7]. Fortunately, nanocarrier-based delivery systems have shown great potential to overcome these issues [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment

et al. 2017

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Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metastatic osteosarcoma. Curcumin (Cur) has shown its potential for the treatment of many cancers; however, the clinical implication of native curcumin is severely hindered by its intrinsic property. In this study, a mixed system of monomethoxy (polyethylene glycol)-poly(d, l-lactide-co-glycolide)/poly(ε-caprolactone) (mPEG-PLGA/PCL) was used to build a formulation of curcuminencapsulated nanoparticles (Cur-NPs), which significantly improved the solubility, stability and cellular uptake of curcumin. Moreover, the Cur-NPs were superior to free curcumin in the matter of inhibition on the proliferation, migration and invasion of osteosarcoma 143B cells. It was found that both free curcumin and Cur-NPs could decrease the expressions of c-Myc and MMP7 in the level of mRNA and protein, which explained why free curcumin and Cur-NPs could inhibit the proliferation and invasion of metastatic osteosarcoma 143B cells. The Cur-NPs provided a promising strategy for metastatic osteosarcoma treatment.

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“…Nanotechnology was used to encapsulate curcumin in the hydrophobic core of polymeric micelles (Hu et al, 2014b;Liu et al, 2013;Yallapu et al, 2012). In the present work, curcumin loaded micelles were prepared with theoretical drug loading of 6.0 and 12.0% using membrane hydration method, in comparison with blank micelles.…”

Section: Preparation and Characterization Of Drug Loaded Micellesmentioning

confidence: 99%

Thermo-responsive drug release from self-assembled micelles of brush-like PLA/PEG analogues block copolymers

Darcos

Monge

et al. 2015

International Journal of Pharmaceutics

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Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis

Cited by 148 publications

References 26 publications

Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin

Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin

Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment

Thermo-responsive drug release from self-assembled micelles of brush-like PLA/PEG analogues block copolymers

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