Curcumin-Loaded Bacterial Cellulose/Alginate/Gelatin as A Multifunctional Biopolymer Composite Film

Abstract

Multifunctional biopolymer composites comprising mechanically-disintegrated bacterial cellulose, alginate, gelatin and curcumin plasticized with glycerol were successfully fabricated through a simple, facile, cost-effective mechanical blending and casting method. SEM images indicate a well-distributed structure of the composites. The water contact angles existed in the range of 50–70°. Measured water vapor permeability values were 300–800 g/m2/24 h, which were comparable with those of commercial dressing products. No release of curcumin from the films was observed during the immersion in PBS and artificial saliva, and the fluid uptakes were in the range of 100–700%. Films were stretchable and provided appropriate stiffness and enduring deformation. Hydrated films adhered firmly onto the skin. In vitro mucoadhesion time was found in the range of 0.5–6 h with porcine mucosa as model membrane under artificial saliva medium. The curcumin-loaded films had substantial antibacterial activity against E. coli and S. aureus. The films showed non-cytotoxicity to human keratinocytes and human gingival fibroblasts but exhibited potent anticancer activity in oral cancer cells. Therefore, these curcumin-loaded films showed their potential for use as leave-on skin applications. These versatile films can be further developed to achieve desirable characteristics for local topical patches for wound care, periodontitis and oral cancer treatment.

Curcumin-Alginate Mixed Nanocomposite: An Evolving Therapy for Wound Healing

“…Graphene oxide is one of the most preferable material which have characteristics like biocompatibility, greater surface area, high mechanical strength and also antimicrobial activity. Gymnema sylvestre is commonly known as "Gumar" plant product also having anti-inflammatory, antimicrobial properties [160]. Fabrication of a novel scaffold was done consisting of curcumin and Gymnema sylvestre incorporated graphene oxide polyhydroxy butyrate-sodium alginate (GO-PHB-SA-CUR and GS) composite as an extracellular matrix platform to improve wound healing in normal and diabetic wounds [160].…”

“…Gymnema sylvestre is commonly known as "Gumar" plant product also having anti-inflammatory, antimicrobial properties [160]. Fabrication of a novel scaffold was done consisting of curcumin and Gymnema sylvestre incorporated graphene oxide polyhydroxy butyrate-sodium alginate (GO-PHB-SA-CUR and GS) composite as an extracellular matrix platform to improve wound healing in normal and diabetic wounds [160]. Curcumin and Gymnema sylvestre were integrated into the novel graphene oxide-polyhydroxybutyrate sodium alginate composite scaffold prepared by solution casting to enhance wound healing in regular and diabetic wounds for better tissue regeneration use.…”

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

“…Alginate in combination with bacterial cellulose and gelatin can generate multifunctional composites capable of sustainably loading and releasing curcumin. [ 66 ]. Hydrated films adhered firmly onto the skin, tests were performed on pig skin in artificial saliva, revealing an adhesion time of up to 6 h. Curcumin-bearing films had substantial antibacterial activity against Escherichia coli and Staphylococcus aureus, which are not cytotoxic to human keratinocytes and human gingival fibroblasts but exhibited potent anticancer activity in oral cancer cells.…”

Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(N,N-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin

“…Hydrogels constitute another source for construction of various DDS [19][20][21]. Controlled delivery of CCM from synthetic polymeric membranes [22] and multifunctional composite films based on natural polymers [23] has recently been reported. Although many natural polymers can be used to produce hydrogels, the structural versatility characteristic to hydrogels based on synthetic polymers and their response to multiple external stimuli make them very attractive.…”