Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway

Lee, Hsiang-Ping; Li, Te‐Mao; Tsao, Jung-Ying; Fong, Yi‐Chin; Tang, Chih‐Hsin

doi:10.1016/j.intimp.2012.04.002

Cited by 49 publications

(31 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…p53 was also evaluated in this study, and it was shown to be able to participate of death receptor increased expression. Taken together, these results suggest that curcumin-induced cell death in chondrosarcoma cells occurs by extrinsic pathway [315]. …”

Section: Cellular Deathmentioning

confidence: 95%

Unraveling the Anticancer Effect of Curcumin and Resveratrol

et al. 2016

View full text Add to dashboard Cite

Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs.

show abstract

Section: Cellular Deathmentioning

confidence: 95%

Unraveling the Anticancer Effect of Curcumin and Resveratrol

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Curcumin are used to suppress the expression of membrane surface adhesion moleculesand induce the degradation of intercellular adhesion molecules (ICAMs) including β-catenin and E-cadherin (13). Curcumin inhibits the cytokines promoting the growth of tumor cells such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1).…”

Section: Targeting Factors Interfering With Invasion and Migrationmentioning

confidence: 99%

Current insight on anti-tumor effect of natural products

Hao¹,

Liang²,

Zhang³

et al. 2016

Eur J Bio Med Res

View full text Add to dashboard Cite

Abstract:Various clinical practices prove that traditional Chinese medicines, integrated traditionalChinese and western medicines make enormous contributions to tumor treatment as well as alleviation of chemotherapy side effect. Alkaloid, polysaccharide and saponin are examples of natural bioactive products that can impede the progression of tumors. Besides, researches on the widely-used tradition Chinese anti-tumor medicine formulas indicate that these agents can induce apoptosis of tumor cells. Therefore, there is an extensive perspective in natural bioactive materials as clinical tumor therapy. This review provides an overview of some natural products used as anti-tumor remedies and the molecular mechanisms they are involved in apoptosis induction, tumor angiogenesis and tumor metastasis.

show abstract

“…Fas (CD95/APO-1) was a cell surface receptor protein which induced apoptosis on binding FasL (Lee et al, 2012). RT-PCR was used to identify the expression of Fas and FasL genes.…”

Section: β-Elemene Promoted Fas/fasl Caspase-3 and Bax Expression Anmentioning

confidence: 99%