2014
DOI: 10.1007/s11033-014-3769-2
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Abstract: Melanoma is the most malignant skin cancer and is highly resistant to chemotherapy and radiotherapy. Curcumin is a component of turmeric, the yellow spice derived from the rhizome of Curcuma longa. It has been demonstrated to modulate multiple cell signaling pathways, including apoptosis, proliferation, angiogenesis and inflammation. In this study, we studied the signaling pathways involved in melanoma cell death after treatment with curcumin using western blotting. Colorimetric assays (MTT) assessed cell viab… Show more

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Cited by 61 publications
(26 citation statements)
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“…Thus, we could not conclude that the downregulation of the NF-κB pathway is the main mechanism of action of curcumin. A possible alternative explanation is that curcumin exerts its anti-inflammatory property by a direct modulation of mitochondrial function, as suggested by other authors [42]. …”
Section: Discussionmentioning
confidence: 94%
“…Thus, we could not conclude that the downregulation of the NF-κB pathway is the main mechanism of action of curcumin. A possible alternative explanation is that curcumin exerts its anti-inflammatory property by a direct modulation of mitochondrial function, as suggested by other authors [42]. …”
Section: Discussionmentioning
confidence: 94%
“…Topical application of commercial-grade curcumin (containing ~77% curcumin, 17% demethoxycurcumin and 3% bis-demethoxycurcumin), pure curcumin or demethoxycurcumin exhibited almost equipotent inhibitory effects on TPA-induced tumor promotion in DMBA-initiated mouse skin carcinogenesis. Jiang et al demonstrated that curcumin is able to induce apoptosis and inhibit the proliferation of melanoma cells (70). In addition, curcumin treatment altered the expression levels of the apoptosis-associated proteins, NF-κB, p38 and p53 (70).…”
Section: Skin Carcinogenesismentioning
confidence: 99%
“…The mRNA expression was expressed as fold change (a), protein expression was given as band (b), and "c" represents the densitometry values of "b" scavenger by reducing DNA damage and lipid peroxidation (Srivastava, Singh, Dubey, Misra, & Khar, 2011). Curcumin has been reported to induce apoptosis by the activation of caspases through the mitochondrial signaling pathway in melanoma cells (Jiang, Jiang, Li, & Zheng, 2015).…”
Section: Discussionmentioning
confidence: 99%