Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells

Lee, Shu-Mei; Chiang, Shu-Hua; Wang, Hsun-Yen; Wu, Pey-Shiuan; Lin, Chih-Chien

doi:10.1080/09168451.2014.972324

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…The cells incubated as above were plated at a density of 2000 cells/well (cancer cells) [ 18 , 41 , 42 ] or 10,000 cells/well (Detroit 551) on a 96-well plate for 24 h; serial dilutions of indicated compounds were added and incubated for additional 72 h. At the end of the incubation, cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT). The MTT formazan crystals were dissolved by DMSO, and the absorbance at 570 nm using a microplate spectrophotometer (Thermo Fisher Scientific, Waltham, MA, USA) [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

Yang

Lee

2017

Molecules

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Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. This study reports our strategy for designing and synthesizing a series of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential multi-target tyrosine kinase receptor inhibitors. The target compounds were obtained by condensation of 5-substituted oxindoles with N-substituted 2-pyrrolidone aldehyde 7 in satisfactory yields. Of these, 11 and 12 had the highest potency and, compared to sunitinib, showed: (1) significant increase in anti-proliferation of various cancer cells with a favorable selective index (SI); (2) higher inhibitory potency against both VEGFR-2 and PDGFRβ. The molecular modeling results showed that, in terms of VEGFR-2 binding, the synthesized products had a similar binding mode to sunitinib but with tighter interaction.

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Section: Methodsmentioning

confidence: 99%

Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

Yang

Lee

2017

Molecules

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“…Lastly, the cells were lysed with 100 μL of DMSO, and the absorbance was measured spectrophotometrically at 540 nm using an ELISA reader. The inhibitory concentration value at 50% cell viability is defined as IC 50 [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Hair Dyes Resorcinol and Lawsone Reduce Production of Melanin in Melanoma Cells by Tyrosinase Activity Inhibition and Decreasing Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expression

Lee

Chen

Lin

et al. 2015

IJMS

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Hair coloring products are one of the most important cosmetics for modern people; there are three major types of hair dyes, including the temporary, semi-permanent and permanent hair dyes. The selected hair dyes (such as ammonium persulfate, sodium persulfate, resorcinol and lawsone) are the important components for hair coloring products. Therefore, we analyzed the effects of these compounds on melanogenesis in B16-F10 melanoma cells. The results proved that hair dyes resorcinol and lawsone can reduce the production of melanin. The results also confirmed that resorcinol and lawsone inhibit mushroom and cellular tyrosinase activities in vitro. Resorcinol and lawsone can also downregulate the protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16-F10 cells. Thus, we suggest that frequent use of hair dyes may have the risk of reducing natural melanin production in hair follicles. Moreover, resorcinol and lawsone may also be used as hypopigmenting agents to food, agricultural and cosmetic industry in the future.

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“…Waqas et al [70] used an elastometer to confirm the anti-ageing and elasticity-inducing effect on the skin following treatment with a cosmetic formulation containing soybean extract. Lee et al [71] suggested curcumin as a potential cosmetic ingredient after observing that it increases the expression of tropoelastin in human dermal fibroblasts.…”

Section: Cosmetics and Photoageingmentioning

confidence: 99%

Elastin structure and its involvement in skin photoageing

Weihermann

Lorencini

Brohem

et al. 2016

Intern J of Cosmetic Sci

139

102

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Skin aging is a complex process that may be caused by factors that are intrinsic and extrinsic to the body. Ultraviolet (UV) radiation represents one of the main sources of skin damage over the years and characterizes a process known as photoaging. Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by changes in elastin production, increased degradation and/or processing produces a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers. The occurrence of UV radiation-induced alternative splicing of the elastin gene, which leads to inadequate synthesis of the proteins required for the correct assembly of elastic fibers, is a potential explanation for this phenomenon. Innovative studies have been fundamental for the elucidation of rarely explored photoaging mechanisms and have enabled the identification of effective therapeutic alternatives such as cosmetic products. This review addresses cutaneous photoaging and the changes that affect elastin in this process.R esum e Le vieillissement de la peau est un processus complexe qui peutêtre caus e par des facteurs intrins eques et extrins eques du corps. Les rayons ultraviolets (UV) repr esentent l'une des principales sources de dommages de la peau au fil des ans et caract erise un processus connu sous le nom de photo-vieillissement. Parmi les changements qui affectent le tissu cutan e avec l'âge, la perte des propri et es elastiques caus ees par des changements dans la production d' elastine, augmentation de la d egradation et / ou le traitement, produit un impact important sur l'esth etique et la sant e des tissus. La survenue d'une elastose solaire est l'un des principaux marqueurs de photo-vieillissement cutan e et se caract erise par un d epôt d esordonn e et non-fonctionnel des fibres elastiques. L'apparition d'un epissage alternatif du g ene de l' elastine induit par le rayonnement UV, ce qui conduit a une synth ese insuffisante des prot eines n ecessaires a l'assemblage correct des fibres elastiques, est une explication possible de ce ph enom ene. Des etudes novatrices ont et e fondamentales pour l' elucidation des m ecanismes de photovieillissement rarement explor es et ont permis l'identification d'alternatives th erapeutiques efficaces, tels que les produits cosm etiques. Cette revue porte sur le photo-vieillissement cutan e et les changements qui affectent l' elastine dans ce processus.

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Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells

Cited by 9 publications

References 27 publications

Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

Hair Dyes Resorcinol and Lawsone Reduce Production of Melanin in Melanoma Cells by Tyrosinase Activity Inhibition and Decreasing Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expression

Elastin structure and its involvement in skin photoageing

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