volume 54, issue 2, P14 2018
DOI: 10.3390/medicina54020014
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Anita Berzina, Inese Martinsone, Simons Svirskis, Modra Murovska, Martins Kalis

Abstract: Background and Objective: In Wilson’s disease, copper metabolism is impaired due to defective copper transporting protein ATP7B, resulting in copper accumulation in liver and brain and causing damage to liver and brain tissues. Published data suggest that one of the possible treatments for Wilson’s disease is curcumin—a compound found in the root of Curcuma longa. In this study, we tested whether curcumin affects copper transport and excretion in HepG2 hepatocytes carrying wildtype ATP7B. Materials and Methods…

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